01694nas a2200169   4500008004100000022001400041245013600055210006900191260007100260300001600331490000700347520096900354100002601323700002601349700002801375856012101403       2005                        eng d  a0022-326300aPreorganizing linear (self-complementary) quadruple hydrogen-bonding arrays using intramolecular hydrogen bonding as the sole force0 aPreorganizing linear selfcomplementary quadruple hydrogenbonding  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a10067-100720 v703 a<p>In this article we describe a rational approach for prefixing multiple cooperative binding sites in an ideal spatial arrangement on a structurally rigid backbone, constrained exclusively by intramolecular hydrogen bonding. The idea is exemplified by the ability of the self-assembling constructs la-e and 2a,b to form hydrogen-bonded dimers, whose structural preorganization has been solely effected by intramolecular hydrogen bonding. The readily accessible amidinourea backbone has been used as a common platform for the construction of a variety of such self-assembling systems. ESI mass spectrometry and single-crystal X-ray diffraction studies have been particularly effective in investigating the self-assembling propensities of these systems. Remarkably, most the H-bonded dimers reported herein undergo an unusual mode of self-assembly, using intermolecular four-membered ring hydrogen-bonded interaction, affording extended supramolecular networks.</p>1 aPrabhakaran, Panchami1 aPuranik, Vedavati, G.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/preorganizing-linear-self-complementary-quadruple-hydrogen-bonding-arrays-using-001502nas a2200181   4500008004100000022001400041245014500055210006900200260010600269300001400375490000700389520070700396100002301103700002401126700002401150700002801174856011801202       2008                        eng d  a0040-403900aPre-organization-mediated macrocylization: efficient synthesis and structural investigations of BINOL-m-phenylenediamine-derived macrocycles0 aPreorganizationmediated macrocylization efficient synthesis and   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a2139-21420 v493 a<p>This letter describes a serendipitous discovery of an efficient synthetic route to BINOL-m-phenylenediamine-derived macrocycles. These macrocycles are quickly accessible in an one-pot procedure by the direct condensation of (R) and (S) BINOL bis-acids with suitably substituted m-phenylenediamine analogs. Structural investigations by single crystal X-ray crystallography and solution-state NMR studies provided convincing evidence of their intramolecular hydrogen bonding arrangement and rigid structural architecture. The striking feature of these macrocycles is their ready accessibility in optically pure form coupled with their ease of synthesis. (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aSrinivas, Deekonda1 aGonnade, Rajesh, G.1 aRajamohanan, P., R.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/pre-organization-mediated-macrocylization-efficient-synthesis-and-structural-001445nas a2200205   4500008004100000022001400041245009200055210006900147260011000216300001600326490000600342520063800348100001400986700002201000700002301022700002601045700002401071700002801095856011601123       2014                        eng d  a2046-206900aProbing the folding induction ability of orthanilic acid in peptides: some observations0 aProbing the folding induction ability of orthanilic acid in pept  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a13018-130250 v43 a<p>This paper describes the ability of orthanilic acid (2-aminobenzenesulfonic acid, (S)Ant) to promote folding when introduced in a peptide sequence. Three peptide sequences, containing orthanilic acid (SAnt) with a sulfonamide moiety in the turn segment, have been synthesized in the solution phase using suitable coupling agents, and their structural aspects investigated using NMR and X-ray crystallographic studies. Solid- and solution-state conformational analyses reveal that the peptide sequences containing orthanilic acid in their backbone exist in a folded conformation featuring long-range 15-membered ring H-bonding.</p>1 aRoy, Arup1 aKotmale, Amol, S.1 aGawade, Rupesh, L.1 aPuranik, Vedavati, G.1 aRajamohanan, P., R.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/probing-folding-induction-ability-orthanilic-acid-peptides-some-observations