01950nas a2200265   4500008004100000022001400041245012600055210006900181260007700250300001600327490000700343520093400350653002701284653001601311653003601327653001301363653002501376100002201401700002401423700002601447700002201473700003501495700002401530856013001554       2011                        eng d  a0947-653900aSynthesis and structural characterization of homochiral homo-oligomers of parent CIS- and trans-furanoid-beta-amino acids0 aSynthesis and structural characterization of homochiral homoolig  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcNOV  a12946-129540 v173 a<p>The synthesis of homochiral homo-oligomers of cis- and trans-3-aminotetrahydrofuran-2-carboxylic acids (parent cis- and trans-furanoid-beta-amino acids, referred to as ``cis-/trans-FAA'') has been carried out to understand their secondary structures and their dependence on the ring heteroatom. The oligomers of two diastereomers have been shown to have a distinct left-handed helicity. The cis-FAA homo-oligomers show a 14-helix structure, in contrast to the homo-oligomers of cis-ACPC, which adopt a sheet like structure. The trans-FAA homo-oligomers were found to adopt a 12-helix structure, the same trend found in trans-ACPC homo-oligomers. With the help of ab initio calculations, the structural features of cis-ACPC and cis-FAA hexamers were compared. We believe that the more compact packing of the cis-FAA hexapeptide should be due to a more favorable interaction between the ring and the backbone amide hydrogen.</p>10aab initio calculations10aAmino acids10aDensity functional calculations10aPeptides10asecondary structures1 aPandey, Sunil, K.1 aJogdand, Ganesh, F.1 aOliveira, Joao, C. A.1 aMata, Ricardo, A.1 aRajamohanan, Pattuparambil, R.1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/synthesis-and-structural-characterization-homochiral-homo-oligomers-parent-cis-and-trans-001362nas a2200229   4500008004100000022001400041245014900055210006900204260007700273300001400350520043900364653001600803653002300819653002400842653001300866100002100879700002400900700003500924700002200959700002400981856012701005       2012                        eng d  a1434-193X00aSynthesis and structural characterization of homochiral homo-oligomers of cis-gamma-methoxy-substituted cis- and trans-furanoid-beta-amino acids0 aSynthesis and structural characterization of homochiral homoolig  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcMAY  a2656-26633 a<p>Herein we describe the synthesis of cis-/trans-3-aminotetrahydrofuran-2-carboxylic acids (cis-/trans-FAA) having a ?-methoxy group cis to the amine. The homo-oligomers of these two diastereomeric FAAs have been prepared. Preliminary investigation of their solution secondary structures revealed that they are the same as the homo-oligomers of the parent cis-/trans-FAA with the methoxy group only being a spectator substituent.</p>10aAmino acids10ahelical structures10aOxygen heterocycles10aPeptides1 aGiri, Awadut, G.1 aJogdand, Ganesh, F.1 aRajamohanan, Pattuparampil, R.1 aPandey, Sunil, K.1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/synthesis-and-structural-characterization-homochiral-homo-oligomers-cis-gamma-methoxy-0