01535nas a2200157   4500008004100000022001400041245010400055210006900159260007100228300001200299490000700311520089400318100001401212700002401226856012701250       2005                        eng d  a0001-484200aConformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity0 aConformationally constrained PNA analogues structural evolution   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY  a404-4120 v383 a<p>Since its discovery 12 years ago, aminoethylglycyl peptide nucleic acid (aeg-PNA) has emerged as one of the successful DNA mimics for potential therapeutic and diagnostic applications. An important requisite for in vivo applications that has received inadequate attention is engineering PNA analogues for able discrimination between DNA and RNA as binding targets. Our approach toward this aim is based on structural preorganization of the backbone to hybridization-competent conformations to impart binding selectivity. This strategy has allowed us to design locked PNAs to achieve specific hybridization with DNA or RNA with aims to increase the binding strength without losing the binding specificity. This Account presents results of our rationale in design of different conformationally constrained PNA analogues, their synthesis, and evaluation of hybridization specificities.</p>1 aKumar, VA1 aGanesh, Krishna, N.  uhttps://library.ncl.res.in/content/conformationally-constrained-pna-analogues-structural-evolution-toward-dnarna-binding-001194nas a2200181   4500008004100000022001400041245007700055210006900132260010600201300001400307490000700321520049900328653001700827653000800844100002300852700002400875856011300899       2008                        eng d  a0040-403900aCyanuryl peptide nucleic acid: synthesis and DNA complexation properties0 aCyanuryl peptide nucleic acid synthesis and DNA complexation pro  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a1314-13180 v493 a<p>The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N'-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer. (c) 2008 Elsevier Ltd. All rights reserved.</p>10acyanuryl PNA10aPNA1 aVysabhattar, Raman1 aGanesh, Krishna, N.  uhttps://library.ncl.res.in/content/cyanuryl-peptide-nucleic-acid-synthesis-and-dna-complexation-properties-0