03256nas a2200685   4500008004100000022001400041245005700055210005200112260007100164300001400235490000700249520122200256100002801478700002001506700002301526700001901549700002401568700003001592700002501622700002401647700001801671700002501689700002501714700002101739700002701760700001701787700002501804700002101829700002001850700001801870700001801888700001901906700002201925700002101947700002301968700001601991700002502007700001902032700001702051700002802068700002202096700002102118700002002139700001502159700001802174700001602192700002302208700002402231700002002255700002502275700002602300700002302326700001902349700002202368700002502390700002302415700002102438700002702459856008402486       2012                        eng d  a1528-748300aPolymorphs, salts, and cocrystals: what's in a name?0 aPolymorphs salts and cocrystals whats in a name  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY  a2147-21520 v123 a<p>The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) addressed two matters of topical interest to the crystal engineering and pharmaceutical science communities: (1) a proposed definition of cocrystals; (2) a proposed classification of pharmaceutical cocrystals as dissociable ``API-excipient'' molecular complexes. The Indo U.S. Bilateral Meeting sponsored by the Indo-U.S. Science and Technology Forum titled The Evolving Role of Solid State Chemistry in Pharmaceutical Science was held in Manesar near Delhi, India, from February 2-4, 2012. A session of the meeting was devoted to discussion of the FDA guidance draft. The debate generated strong consensus on the need to define cocrystals more broadly and to classify them like salts. It was also concluded that the diversity of API crystal forms makes it difficult to classify solid forms into three categories that are mutually exclusive. This perspective summarizes the discussion in the Indo-U.S. Bilateral Meeting and includes contributions from researchers who were not participants in the meeting.</p>1 aAitipamula, Srinivasulu1 aBanerjee, Rahul1 aBansal, Arvind, K.1 aBiradha, Kumar1 aCheney, Miranda, L.1 aChoudhury, Angshuman, Roy1 aDesiraju, Gautam, R.1 aDikundwar, Amol, G.1 aDubey, Ritesh1 aDuggirala, Nagakiran1 aGhogale, Preetam, P.1 aGhosh, Soumyajit1 aGoswami, Pramod, Kumar1 aGoud, Rajesh1 aJetti, Ram, R. K. R.1 aKarpinski, Piotr1 aKaushik, Poonam1 aKumar, Dinesh1 aKumar, Vineet1 aMoulton, Brian1 aMukherjee, Arijit1 aMukherjee, Gargi1 aMyerson, Allan, S.1 aPuri, Vibha1 aRamanan, Arunachalam1 aRajamannar, T.1 aReddy, Malla1 aRodriguez-Hornedo, Nair1 aRogers, Robin, D.1 aRow, T., N. Guru1 aSanphui, Palash1 aShan, Ning1 aShete, Ganesh1 aSingh, Amit1 aSun, Changquan, C.1 aSwift, Jennifer, A.1 aThaimattam, Ram1 aThakur, Tejender, S.1 aThaper, Rajesh, Kumar1 aThomas, Sajesh, P.1 aTothadi, Srinu1 aVangala, Venu, R.1 aVariankaval, Narayan1 aVishweshwar, Peddy1 aWeyna, David, R.1 aZaworotko, Michael, J.  uhttps://library.ncl.res.in/content/polymorphs-salts-and-cocrystals-whats-name-002045nas a2200661   4500008004100000022001400041245008000055210006900135260007100204300001400275490000700289100002800296700002000324700002300344700001900367700002400386700003000410700002500440700002400465700001800489700002500507700002500532700002100557700002700578700001700605700002500622700002100647700002000668700001800688700001800706700001900724700002200743700002100765700002300786700001600809700002500825700001900850700001700869700002800886700002200914700002100936700002000957700001500977700001800992700001601010700002301026700002401049700002001073700002501093700002601118700002301144700001901167700002201186700002301208700002101231700002701252856010401279       2012                        eng d  a1528-748300aPolymorphs, salts and cocrystals: what's in a name? (vol 12, pg 2147, 2012)0 aPolymorphs salts and cocrystals whats in a name vol 12 pg 2147 2  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAUG  a4290-42910 v121 aAitipamula, Srinivasulu1 aBanerjee, Rahul1 aBansal, Arvind, K.1 aBiradha, Kumar1 aCheney, Miranda, L.1 aChoudhury, Angshuman, Roy1 aDesiraju, Gautam, R.1 aDikundwar, Amol, G.1 aDubey, Ritesh1 aDuggirala, Nagakiran1 aGhogale, Preetam, P.1 aGhosh, Soumyajit1 aGoswami, Pramod, Kumar1 aGoud, Rajesh1 aJetti, Ram, R. K. R.1 aKarpinski, Piotr1 aKaushik, Poonam1 aKumar, Dinesh1 aKumar, Vineet1 aMoulton, Brian1 aMukherjee, Arijit1 aMukherjee, Gargi1 aMyerson, Allan, S.1 aPuri, Vibha1 aRamanan, Arunachalam1 aRajamannar, T.1 aReddy, Malla1 aRodriguez-Hornedo, Nair1 aRogers, Robin, D.1 aRow, T., N. Guru1 aSanphui, Palash1 aShan, Ning1 aShete, Ganesh1 aSingh, Amit1 aSun, Changquan, C.1 aSwift, Jennifer, A.1 aThaimattam, Ram1 aThakur, Tejender, S.1 aThaper, Rajesh, Kumar1 aThomas, Sajesh, P.1 aTothadi, Srinu1 aVangala, Venu, R.1 aVishweshwar, Peddy1 aWeyna, David, R.1 aZaworotko, Michael, J.  uhttps://library.ncl.res.in/content/polymorphs-salts-and-cocrystals-whats-name-vol-12-pg-2147-2012-001962nas a2200193   4500008004100000245014800041210006900189260000800258300001400266490000700280520122900287100001901516700002301535700001701558700002701575700002001602700002001622856012601642       2016                        eng d00aTracing the architecture of caffeic acid phenethyl ester cocrystals: studies on crystal structure, solubility, and bioavailability implications0 aTracing the architecture of caffeic acid phenethyl ester cocryst  cOCT  a5710-57160 v163 a<p>Caffeic acid phenethyl ester (CAPE) is a polyphenolic active compound present in popular apiproduct, "propolis", obtained from beehives, Though it has broad therapeutic capability, the bioavailability of CAPE is limited due to poor solubility. In this study, we report novel cocrystals of CAPE engineered using coformers such as caffeine (CAP), isonicotinamide (INIC), and nicotinamide (NIC) with enhanced solubility and bioavailability of CAPE. The cocrystals were prepared by microwave-assisted cocrystallization and characterized using PXRD, DSC, and Raman spectroscopy. PXRD and DSC confirm the successful formation and phase purity of CAPE-CAF, CAPE-INIC, and CAPE-NIC cocrystals. Raman spectra of CAPE cocrystals complement these results in confirming the formation of novel crystalline phases. CAPE-NIC cocrystal was further subjected X-ray crystallography to understand its molecular arrangement and hydrogen bonding in the crystal structure. The CAPE-NIC cocrystal structure is found to be stabilized by a rare 1,2-benzenediol-amide heterosynthon. Cocrystallization of CAPE with NIC improved its aqueous solubility and pharmacokinetic profile, thereby demonstrating a 2.76-fold escalation in bioavailability.</p>1 aKetkar, Sameer1 aPagire, Sudhir, K.1 aGoud, Rajesh1 aMahadik, Kakasaheb, R.1 aNangia, Ashwini1 aParadkar, Anant  uhttps://library.ncl.res.in/content/tracing-architecture-caffeic-acid-phenethyl-ester-cocrystals-studies-crystal-structure