02321nas a2200289   4500008004100000022001400041245013600055210006900191260011100260300001200371490000700383520126500390653002001655653003401675653001401709653001601723653001601739100001401755700001801769700001501787700001401802700002201816700002601838700002301864700001801887856012601905       2012                        eng d  a1566-524000aAndrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 Kinase/Akt signaling pathway0 aAndrographolide inhibits osteopontin expression and breast tumor  aEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATESbBENTHAM SCIENCE PUBL LTDcSEP  a952-9660 v123 a<p>Breast cancer is one of the most common cancers among women in India and around the world. Despite recent advancement in the treatment of breast cancer, the results of chemotherapy to date remain unsatisfactory, prompting a need to identify natural agents that could target cancer efficiently with least side effects. Andrographolide (Andro) is one such molecule which has been shown to possess inhibitory effect on cancer cell growth. In this study, Andro, a natural diterpenoid lactone isolated from Andrographis paniculata has been shown to inhibit breast cancer cell proliferation, migration and arrest cell cycle at G2/M phase and induces apoptosis through caspase independent pathway. Our experimental evidences suggest that Andro attenuates endothelial cell motility and tumor-endothelial cell interaction. Moreover, Andro suppresses breast tumor growth in orthotopic NOD/SCID mice model. The anti-tumor activity of Andro in both in vitro and in vivo model was correlated with down regulation of PI3 kinase/Akt activation and inhibition of pro-angiogenic molecules such as OPN and VEGF expressions. Collectively, these results demonstrate that Andro may act as an effective anti-tumor and anti-angiogenic agent for the treatment of breast cancer.</p>10aAndrographolide10aangiogenesis and breast tumor10amigration10aosteopontin10aPI 3 kinase1 aKumar, S.1 aPatil, H., S.1 aSharma, P.1 aKumar, D.1 aDasari, Sreekanth1 aPuranik, Vedavati, G.1 aThulasiram, H., V.1 aKundu, G., C.  uhttps://library.ncl.res.in/content/andrographolide-inhibits-osteopontin-expression-and-breast-tumor-growth-through-down-001836nas a2200217   4500008004100000022001400041245010100055210006900156260000800225300001400233490000800247520111800255100001401373700001901387700001901406700001901425700001401444700001701458700001701475856012601492       2017                        eng d  a0002-786300aConstructing ultraporous covalent organic fameworks in seconds via an organic terracotta process0 aConstructing ultraporous covalent organic fameworks in seconds v  cFEB  a1856-18620 v1393 a<p>Research on covalent organic frameworks (COFs) has recently gathered significant momentum by the virtue of their predictive design, controllable porosity, and long-range ordering. However, the lack of solvent-free and easy-to-perform synthesis processes appears to be the bottleneck toward their greener fabrication, thereby limiting their possible potential applications. To alleviate such shortcomings, we demonstrate a simple route toward the rapid synthesis of highly crystalline and ultraporous COFs in seconds using a novel salt-mediated crystallization approach. A high degree of synthetic control in interlayer stacking and layer planarity renders an ordered network with a surface area as high as 3000 m(2) g-(1). Further, this approach has been extrapolated for the continuous synthesis of COFs by means of a twin screw extruder and in situ processes of COFs into different shapes mimicking the ancient terracotta process. Finally, the regular COF beads are shown to outperform the leading zeolites in water sorption performance, with notably facile regeneration ability and structural integrity.</p>1 aKarak, S.1 aKandambeth, S.1 aBiswal, B., P.1 aSasmal, H., S.1 aKumar, S.1 aPachfule, P.1 aBanerjee, R.  uhttps://library.ncl.res.in/content/constructing-ultraporous-covalent-organic-fameworks-seconds-organic-terracotta-process01231nas a2200181   4500008004100000245018300041210006900224260000800293300001600301490000600317520051700323100001500840700001500855700002200870700001400892700001500906856012800921       2017                        eng d00aEfficient trifluoromethylation of C(sp(2))-H functionalized alpha-oxoketene dithioacetals: a route to the regioselective synthesis of functionalized trifluoromethylated pyrazoles0 aEfficient trifluoromethylation of Csp2H functionalized alphaoxok  cJAN  a10150-101530 v73 aAn operationally simple approach for the regioselective construction of diversely substituted trifluoromethylated pyrazoles via nucleophilic trifluoromethylation of iodo-substituted alpha-oxoketene dithioacetals is described. X-ray crystallographic studies confirmed the trifluoromethylation as well as formation of a regioselective cyclized product. Furthermore, trifluoromethylated pyrazoles bearing thiomethyl groups may allow further functionalization and are of considerable interest in medicinal chemistry.1 aSharma, N.1 aKumari, N.1 aChundawat, T., S.1 aKumar, S.1 aBhagat, S.  uhttps://library.ncl.res.in/content/efficient-trifluoromethylation-csp2-h-functionalized-alpha-oxoketene-dithioacetals-route01970nas a2200277   4500008004100000022001400041245010500055210006900160260000800229300001400237490000700251520108800258653003001346653003601376653000801412653001001420653003001430100001701460700002001477700001501497700001401512700001701526700001901543700001401562856011601576       2023                        eng d  a2662-472900aAutomated myocardial infarction and angina detection using second derivative of photoplethysmography0 aAutomated myocardial infarction and angina detection using secon  cSEP  a1259-12690 v463 a<p>
	Photoplethysmography (PPG) based healthcare devices have gained enormous interest in the detection of cardiac abnormalities. Limited research has been implemented for myocardial infarction (MI) detection. Moreover, PPG-based detection of angina is still a research gap. PPG signals are not always informative. Therefore, this research work presents the use of PPG signals and their second derivative to evaluate myocardial infarction and angina using a novel set of morphological features. The obtained morphological features are fed onto the feed-forward artificial neural network for the identification of the type of MI and unstable angina (UA). The initial experiments have been carried out on non-ambulatory (public) subjects for feature extraction and later evaluated on ambulatory (self-generated) databases. The intended method attains accuracy, sensitivity, and specificity of 98%, 97%, 98% on the public database and 94%, 94%, 94% on the self-generated database. The result shows that the proposed set of features can detect MI and UA with significant accuracy.</p>
10aArtificial neural network10aMyocardial infarction detection10aPPG10aSDPPG10aUnstable angina detection1 aNeha, H., K.1 aSardana, H., K.1 aDahiya, N.1 aDogra, N.1 aKanawade, R.1 aSharma, Y., P.1 aKumar, S.  uhttps://library.ncl.res.in/content/automated-myocardial-infarction-and-angina-detection-using-second-derivative