00996nas a2200241 4500008004100000022001400041245006100055210005300116260010600169300001400275490000700289520019300296653001400489653003000503653001300533653001300546653001800559100002600577700002100603700001900624700001900643856009200662 2009 eng d a0040-403900aFacile synthesis of 5,6-dihydro-5-hydroxy-2(1H)-pyridone0 aFacile synthesis of 56dihydro5hydroxy21Hpyridone aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY a2440-24420 v503 a

A short synthesis of 5,6-dihydro-5-hydroxy-2(1H)-pyridone was achieved from L-serine employing Horner-Emmons olefination as the key step. (C) 2009 Elsevier Ltd. All rights reserved.

10aalkaloids10aHorner-Emmons olefination10aL-serine10aPyridone10aZ-selectivity1 aUpadhyay, Puspesh, K.1 aPrasad, Rajendra1 aPandey, Menaka1 aKumar, Pradeep uhttps://library.ncl.res.in/content/facile-synthesis-56-dihydro-5-hydroxy-21h-pyridone-001350nas a2200253 4500008004100000022001400041245010500055210006900160260005600229300001000285490000700295520048400302653001200786653001600798653001300814653001200827653001800839100002000857700001900877700002200896700002500918700002100943856013200964 2010 eng d a1509-811700aKinetics studies and mechanism evolution of the epoxidation of styrene over nanoporous Au doped TS-10 aKinetics studies and mechanism evolution of the epoxidation of s aSOLIPSKA 14A-1, 02-482 WARSAW, POLANDbVERSITAcJAN a72-780 v123 a

{A kinetic investigation of the slurry phase epoxidation of styrene with hydrogen peroxide has been carried out, for the first time, over nanoporous Au doped TS-1 catalyst, in a batch reactor, in the temperature range of 313-333 K. It was found that product selectivity and the rate of reaction are greatly influenced by concentrations of styrene and hydrogen peroxide. Kinetics studies reveal that the mechanism of the reaction is of the ``Redox'' type. The rate equation

10aAu/TS-110aepoxidation10akinetics10astyrene10aStyrene oxide1 aSaxena, Samidha1 aDwivedi, Reena1 aBhadauria, Sheenu1 aChumbhale, Vilas, R.1 aPrasad, Rajendra uhttps://library.ncl.res.in/content/kinetics-studies-and-mechanism-evolution-epoxidation-styrene-over-nanoporous-au-doped-ts-1-002567nas a2200289 4500008004100000022001400041245015400055210006900209260007900278300001400357490000700371520150300378653002401881653002101905653001401926653000801940100002701948700001901975700001901994700001702013700002202030700001802052700002602070700002902096700002102125856013102146 2011 eng d a0196-978100aAntifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans0 aAntifungal activity of novel synthetic peptides by accumulation  a360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAbELSEVIER SCIENCE INCcAUG a1732-17400 v323 a

In the present work, we investigated the antifungal activity of two de novo designed, antimicrobial peptides VS2 and VS3, incorporating unnatural amino acid alpha,beta-dehydrophenylalanine (Delta Phe). We observed that the low-hemolytic peptides could irreversibly inhibit the growth of various Candida species and multidrug resistance strains at MIC(80) values ranging from 15.62 mu M to 250 mu M. Synergy experiments showed that MIC(80) of the peptides was drastically reduced in combination with an antifungal drug fluconazole. The dye PI uptake assay was used to demonstrate peptide induced cell membrane permeabilization. Intracellular localization of the FITC-labeled peptides in Candida albicans was studied by confocal microscopy and FACS. Killing kinetics, PI uptake assay, and the intracellular presence of FITC-peptides suggested that growth inhibition is not solely a consequence of increased membrane permeabilization. We showed that entry of the peptide in Candida cells resulted in accumulation of reactive oxygen species (ROS) leading to cell necrosis. Morphological alteration in Candida cells caused by the peptides was visualized by electron microscopy. We propose that de novo designed VS2 and VS3 peptides have multiple detrimental effects on target fungi, which ultimately result in cell wall disruption and killing. Therefore, these peptides represent a good template for further design and development as antifungal agents. (C) 2011 Elsevier Inc. All rights reserved.

10aAntifungal peptides10aCandida albicans10aCell wall10aROS1 aMaurya, Indresh, Kumar1 aPathak, Sarika1 aSharma, Monika1 aSanwal, Hina1 aChaudhary, Preeti1 aTupe, Santosh1 aDeshpande, Mukund, V.1 aChauhan, Virander, Singh1 aPrasad, Rajendra uhttps://library.ncl.res.in/content/antifungal-activity-novel-synthetic-peptides-accumulation-reactive-oxygen-species-ros-and-002917nas a2200313 4500008004100000022001400041245008300055210006900138260007300207300001400280490000900294520181400303653002302117653003202140653001402172653002102186653003402207100002702241700002802268700002002296700002502316700002202341700002402363700002602387700002602413700002102439700002902460856011402489 2013 eng d a0304-416500aMechanism of action of novel synthetic dodecapeptides against Candida albicans0 aMechanism of action of novel synthetic dodecapeptides against Ca aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcNOV a5193-52030 v18303 a

Background: Three de novo designed low molecular weight cationic peptides (IJ2, IJ3 and IJ4) containing an unnatural amino acid alpha,beta-didehydrophenylalanine (APhe) exhibited potent antifungal activity against fluconazole (FLC) sensitive and resistant clinical isolates of Candida albicans as well as non-albi cans and other yeast and filamentous pathogenic fungi. In the present study, their synthesis, susceptibility of different fungi and the mechanism of anti-candidal action have been elucidated. Methods: The antimicrobial peptides (AMPs) were synthesized by solid-phase method and checked for antifungal activity against different yeasts and fungi by broth microdilution method. Anti-candidal mode of action of the peptides was investigated through detecting membrane permeabilization by confocal microscopy, Reactive Oxygen Species (ROS) generation by fluorometry, apoptosis and necrosis by flow cytometry and cell wall damage using Scanning and Transmission Electron Microscopy. Results and conclusions: The MIC of the peptides against C. albicans and other yeast and filamentous fungal pathogens ranged between 3.91 and 250 mu M. All three peptides exhibited effect on multiple targets in C. albi cans including disruption of cell wall structures, compromised cell membrane permeability leading to their enhanced entry into the cells, accumulation of ROS and induction of apoptosis. The peptides also showed synergistic effect when used in combination with fluconazole (FLC) and caspofungin (CAS) against C. albi cans. General significance: The study suggests that the AMPs alone or in combination with conventional antifungals hold promise for the control of fungal pathogens, and need to be further explored for treatment of fungal infections. (C) 2013 Elsevier By. All rights reserved.

10aAntifungal peptide10aAntimicrobial peptide (AMP)10aApoptosis10aCandida albicans10aReactive Oxygen Species (ROS)1 aMaurya, Indresh, Kumar1 aThota, Chaitanya, Kumar1 aSharma, Jyotsna1 aTupe, Santosh, Genba1 aChaudhary, Preeti1 aSingh, Manoj, Kumar1 aThakur, Indu, Shekhar1 aDeshpande, Mukund, V.1 aPrasad, Rajendra1 aChauhan, Virander, Singh uhttps://library.ncl.res.in/content/mechanism-action-novel-synthetic-dodecapeptides-against-candida-albicans-002328nas a2200193 4500008004100000022001400041245009400055210006900149260011000218300001400328490000600342520154600348100002101894700001901915700002401934700002201958700002701980856012702007 2016 eng d a2040-336400aBioresponsive carbon nano-gated multifunctional mesoporous silica for cancer theranostics0 aBioresponsive carbon nanogated multifunctional mesoporous silica aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcDEC a4537-45460 v83 a

Designing bioresponsive nanocarriers for controlled and efficient intracellular drug release for cancer therapy is a major thrust area in nanomedicine. With recent recognition by the US FDA as a safe material for human trials, mesoporous silica nanoparticles (MSNPs) are being extensively explored as promising theranostic agents. Green fluorescent carbon quantum dots (CQDs), though known as possible alternatives for their more toxic and relatively less efficient predecessors, are less known as gate keepers for drug release control. We report for the first time an efficient bioresponse of CQDs when judiciously designed using glutathione cleavable (redox responsive) disulphide bonds. When the anticancer drug doxorubicin loaded MSNPs are capped with these CQDs, they display promising drug release control on exposure to a mimicked intracellular cancer environment. Their dual functionality is well established with good control on preventing the premature release and exceptional bio-imaging of HeLa cancer cells. Fluorescence images prove selective targeting of HeLa cells by overexpression of folate receptors from the surface functionalised folic acid ligand. Extensive characterisation using XRD, TEM, BET analysis, drug loading tests, drug release kinetics, MTT assay and fluoroscence cell imaging helps in understanding the multi-functionalities of the successful design, extending its scope with exciting prospects towards non-invasive targeted drug delivery and bio-imaging for effective cancer diagnosis and treatment.

1 aPrasad, Rajendra1 aAiyer, Sandhya1 aChauhan, Deepak, S.1 aSrivastava, Rohit1 aSelvaraj, Kaliaperumal uhttps://library.ncl.res.in/content/bioresponsive-carbon-nano-gated-multifunctional-mesoporous-silica-cancer-theranostics-001747nas a2200277 4500008004100000022001400041245007400055210006900129260000800198300001000206490000600216520085000222653002801072653002901100653004101129653002301170653003201193653002201225100001901247700002101266700001701287700001701304700002201321700002401343856010201367 2016 eng d a2352-940700aFluorescent carbon nanodots for targeted in vitro cancer cell imaging0 aFluorescent carbon nanodots for targeted in vitro cancer cell im cSEP a71-770 v43 a

Carbon quantum dots (CQDs or C-dots, <= 10nm in size) are tiny carbon nanoparticles being envisaged in biosensing, bio-imaging and biomolecular/drug delivery. In the present investigation, green fluorescent carbon quantum/nano dots (GCQDs, similar to 3 nm in size) were synthesized through facile chemical slicing method. Further, folic acid (FA) functionalized GCQDs (GCQDs-FA) were obtained to enhance their targeting ability. FA is known to positively influence the binding potential and penetration into the cancer cells because of high abundance of folate receptors (FR) on various cancer cell membranes. We report high biocompatibility, photoluminescence stability and excellent in vitro cancer cell cytoplasm and nucleus targeting performance of GCQDs-FA on MCF-7 breast cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.

10aCancer cell bio-imaging10aCarbon quantum/nano dots10aCell cytoplasm and nucleus targeting10aGreen fluorescence10aPhotoluminescence stability10aTargeting ability1 aAiyer, Sandhya1 aPrasad, Rajendra1 aKumar, Manoj1 aNiryikar, K.1 aJain, Bhanprakash1 aKushwaha, Omkar, S. uhttps://library.ncl.res.in/content/fluorescent-carbon-nanodots-targeted-vitro-cancer-cell-imaging02069nas a2200241 4500008004100000245009300041210006900134260000800203300001600211490000600227520124200233100002401475700002701499700002301526700002301549700002201572700002101594700002901615700002101644700001601665700002201681856012401703 2017 eng d00aNIR light-triggered shrinkable thermoresponsive PNVCL nanoshells for cancer theranostics0 aNIR lighttriggered shrinkable thermoresponsive PNVCL nanoshells  cSEP a44026-440340 v73 aFor the localized treatment of a tumor in a more controlled fashion, several stimuli-responsive nanocarriers and minimally or non-invasive techniques like photothermal therapy (PTT) have emerged. However, PTT is limited to only treatment of small and superficial tumors due to the inability of NIR light to penetrate more and kill the core cells of large and deep-seated tumors. As a preliminary step towards addressing the problem, NIR light-triggered thermoresponsive theranostic nanoshell consisting of chitosan-grafted poly(N-vinyl caprolactam) as core and biocompatible gold as shell (Au PNVCL NS) are synthesized and well characterized by various techniques. PNVCL is polymerized from N-vinyl caprolactam using free radical polymerization method, and chitosan is grafted to raise its lower critical solution temperature (LCST) to hyperthermic temperature (∼43 °C). Surface plasmon resonant gold shell over PNVCL NPs core is assembled by ascorbic acid-driven in situ reduction. Core to shell diameter ratio is controlled to tune the peak in NIR region (750 nm). Therapeutic potential of Au PNVCL NS is determined over breast cancer cells MCF-7, while diagnostic potential is compared with the commercial contrast agent-Omnipaque.1 aChauhan, Deepak, S.1 aSingaravelu, Indulekha1 aGottipalli, Rupesh1 aReddy, Pradeep, K.1 aChikate, Tanmayee1 aGupta, Ramkrishn1 aJahagirdar, Dushyant, N.1 aPrasad, Rajendra1 aDe, Abhijit1 aSrivastava, Rohit uhttps://library.ncl.res.in/content/nir-light-triggered-shrinkable-thermoresponsive-pnvcl-nanoshells-cancer-theranostics01677nas a2200181 4500008004100000245010800041210006900149260000800218300001400226490000700240520100400247100002401251700002101275700002401296700002701320700002201347856012601369 2018 eng d00aDisintegrable NIR light triggered gold nanorods supported liposomal nanohybrids for cancer theranostics0 aDisintegrable NIR light triggered gold nanorods supported liposo cMAY a1510-15180 v293 aIn this work, facile synthesis and application of targeted, dual therapeutic gold nanorods-liposome (GNR-Lipos) nanohybrid for imaging guided photothermal therapy and chemotherapy is investigated. The dual therapeutic GNR-Lipos nanohybrid consists of GNR supported, and doxorubicin (DOX) loaded liposome. GNRs not only serve as a photothermal agent and increase the drug release in intracellular environment of cancer cells, but also provide mechanical strength to liposomes by being decorated both inside and outside of bilayer surfaces. The designed nanohybrid shows a remarkable response for synergistic chemophotothermal therapy compared to only chemotherapy or photothermal therapy. The NIR response, efficient uptake by the cells, disintegration of GNR-Lipos nanohybrid, and synergistic therapeutic effect of photothermal and chemotherapy over breast cancer cells MDA-MB-231 are studied for the better development of a biocompatible nanomaterial based multifunctional cancer theranostic agent.1 aChauhan, Deepak, S.1 aPrasad, Rajendra1 aDevrukhkar, Janhavi1 aSelvaraj, Kaliaperumal1 aSrivastava, Rohit uhttps://library.ncl.res.in/content/disintegrable-nir-light-triggered-gold-nanorods-supported-liposomal-nanohybrids-cancer02261nas a2200181 4500008004100000022001400041245014200055210006900197300001400266490000800280520154500288100002101833700002401854700002401878700002201902700002701924856012801951 2018 eng d a1043-180200aIn vivo examination of folic acid-conjugated gold-silica nanohybrids as contrast agents for localized tumor diagnosis and biodistribution0 aIn vivo examination of folic acidconjugated goldsilica nanohybri a4012-40190 v 293 aEnhanced biocompatibility of nanosized contrast agent with high radiodensity and specific biodistribution is an important parameter for localized tumor imaging and organ safety. Various nanoparticles, especially gold nanorods (GNRs), have been applied for tumor diagnosis. However, their toxicity, nonspecific biodistribution, and easy aggregation are critical issues in cancer medicine. To avoid these issues, encapsulation of the GNRs in the core of nanoscopic mesoporous silica (MS) under ambient conditions, yielding multifunctional nanomaterials for cancer nanomedicine, is a recent and active development. Interestingly, GNR embedded MS nanohybrid (GNR-MS), though a promising material in nanomedicine, is rarely examined for tumor diagnosis, in vivo toxicity, organ safety, contrast ability, and excretion. Herein, we report a systematic in vivo examination of folic acid functionalized GNR-MS (GNR-MS-FA) for localized 4T1 breast tumor diagnosis, organ safety, and excretion using a one-time dose administration. The nanomaterials show good aqueous dispersibility, biocompatibility, high radiodensity, and tumor specific targeting ability (in vitro as well as in vivo). The in vivo tumor diagnosis and specific biodistribution of injected nanomaterials clearly demonstrates their potential for the visualization of tumors deep in the body of mice. In addition, all organs including the healthy glomerulus of the kidney are observed to be free of tissue injuries thereby indicating the superior biocompatibility of the nanomaterials.1 aPrasad, Rajendra1 aAgawane, Sachin, B.1 aChauhan, Deepak, S.1 aSrivastava, Rohit1 aSelvaraj, Kaliaperumal uhttps://library.ncl.res.in/content/vivo-examination-folic-acid-conjugated-gold-silica-nanohybrids-contrast-agents-localized00679nas a2200193 4500008004100000022001400041245009500055210006900150260000800219300001200227490000700239100001900246700002100265700001700286700001700303700002200320700002400342856011900366 2019 eng d a2352-940700aFluorescent carbon nanodots for targeted in vitro cancer cell imaging (vol 4, pg 71, 2016)0 aFluorescent carbon nanodots for targeted in vitro cancer cell im cDEC a236-2400 v171 aAiyer, Sandhya1 aPrasad, Rajendra1 aKumar, Manoj1 aNirvikar, K.1 aJain, Bhanprakash1 aKushwaha, Omkar, S. uhttps://library.ncl.res.in/content/fluorescent-carbon-nanodots-targeted-vitro-cancer-cell-imaging-vol-4-pg-71-201602121nas a2200205 4500008004100000245012900041210006900170260000800239300001600247490000600263520136900269100002101638700002001659700002001679700002401699700002101723700002201744700002701766856012201793 2019 eng d00aGraphene oxide supported liposomes as red emissive theranostics for phototriggered tissue visualization and tumor regression0 aGraphene oxide supported liposomes as red emissive theranostics  cJUL a3312–33200 v23 a

Selective tissue visualization and localized tumor regression without affecting the surrounding healthy tissues are critical concerns in cancer nanomedicine. Importantly, the complete wrapping of a flimsy matrix like liposome by multifunctional graphene oxide is an interesting engineering idea for nanomedicine design. Moreover, designing a safe and biodegradable nanohybrid with significant theranostic ability is a current need for targeted combined therapies. Here, we report a comprehensive result of in vivo tumor diagnosis and phototriggered tumor regression using a biodegradable red emissive nanotheranostic system, viz., graphene oxide flakes fortified liposome (GOF-Lipo), functionalized with folic acid (FA): GOF-Lipo-FA. Graphene oxide support enhances the stability of drug-loaded liposomes in an extracellular environment that prevents the premature release of loaded anticancer drug from the liposomal cavity. Promising outcomes of tumor regression (∼300 to 25 mm3) from organized cellular and animal studies are demonstrated in this work. These studies reveal superior biocompatibility, deep intracellular localization, 4T1 breast tumor diagnosis, and long time tumor binding ability of an injected emissive nanohybrid. Overall, a single dose of designed multifunctional systems demonstrates the best tumor regression.

1 aPrasad, Rajendra1 aYadav, Amit, S.1 aGorain, Mahadeo1 aChauhan, Deepak, S.1 aKundu, Gopal, C.1 aSrivastava, Rohit1 aSelvaraj, Kaliaperumal uhttps://library.ncl.res.in/content/graphene-oxide-supported-liposomes-red-emissive-theranostics-phototriggered-tissue02431nas a2200277 4500008004100000022001400041245015100055210006900206260000800275300001100283490000700294520142900301653002801730653002101758653003301779653001501812653002301827653003701850653002701887100002101914700002201935700002301957700002101980700002602001856012602027 2019 eng d a1567-135600aMolecular studies of NAD- and NADP-glutamate dehydrogenases decipher the conundrum of yeast-hypha dimorphism in zygomycete Benjaminiella poitrasii0 aMolecular studies of NAD and NADPglutamate dehydrogenases deciph cDEC afoz0740 v193 a

Benjaminiella poitrasii, a zygomycete, shows glucose- and temperature-dependent yeast (Y)-hypha (H) dimorphic transition. Earlier, we reported the biochemical correlation of relative proportion of NAD- and NADP-glutamate dehydrogenases (GDHs) with Y-H transition. Further, we observed the presence of one NAD-GDH and two form-specific NADP-GDH isoenzymes in B. poitrasii. However, molecular studies are necessary to elucidate the explicit role of GDHs in regulating Y-H reversible transition. Here, we report the isolation and characterization of one NAD (BpNADGDH, 2.643 kb) and two separate genes, BpNADPGDH I (Y-form specific, 1.365 kb) and BpNADPGDH II (H-form specific, 1.368 kb) coding for NADP-GDH isoenzymes in B. poitrasii. The transcriptional profiling during Y-H transition showed higher BpNADPGDH I expression in Y cells while expression of BpNADPGDH II was higher in H cells. Moreover, the yeast-form monomorphic mutant (Y-5) did not show BpNADPGDH II expression under normal dimorphism triggering conditions. Transformation with H-form specific BpNADPGDH II induced the germ tube formation in Y-5, which confirmed the cause-effect relationship between BpNADPGDH genes and morphological outcome in B. poitrasii. Interestingly, expression of H-form specific BpNADPGDH II also induced germ tube formation in human pathogenic, non-dimorphic yeast Candida glabrata, which further corroborated our findings.

10aBenjaminiella poitrasii10aCandida glabrata10adifferential gene expression10adimorphism10amonomorphic mutant10aNAD/NADP-glutamate dehydrogenase10ayeast-hypha transition1 aPathan, Ejaj, K.1 aGhormade, Vandana1 aPanwar, Sneh, Lata1 aPrasad, Rajendra1 aDeshpande, Mukund, V. uhttps://library.ncl.res.in/content/molecular-studies-nad-and-nadp-glutamate-dehydrogenases-decipher-conundrum-yeast-hypha03141nas a2200253 4500008004100000022001400041245011700055210006900172260000900241300001600250490000700266520227500273653002302548653001902571653002402590653001702614653001202631653002202643653001802665653002902683100002102712700002702733856012702760 2023 eng d a1944-824400aEffective distribution of gold nanorods in ordered thick mesoporous silica: a choice of noninvasive theranostics0 aEffective distribution of gold nanorods in ordered thick mesopor cOCT  a47615-476270 v153 a

Porous silica coated gold nanorod core-shell structures demonstrate a multifunctional role in bioimaging, drug delivery, and cancer therapeutics applications. Here, we address a new approach for effective distribution of gold nanorods (GNRs) in a mesoporous silica (MS) shell, viz., one nanorod in one silica particle (GMS). We have studied that silica coating presents major advantages for the better biocompatibility and stability of GNRs. In this study, two different thicknesses of silica shell over GNRs have been discussed as per the application's need; GNRs in thin silica (11 nm) are fit for phototherapy and bioimaging, whereas thick and porous silica (51 nm) coated gold nanorods are suitable for triggered drug delivery and theranostics. However, effective distribution of GNRs in ordered architecture of thick mesoporous silica (MS, more than 50 nm thickness) with high surface area (more than 1000 m(2)/g) is not well understood so far. Here, we present methodical investigations for uniform and highly ordered mesoporous silica coating over GNRs with tunable thickness (6 to 51 nm). Judicious identification and optimization of different reaction parameters like concentrations of silica precursor (TEOS, 1.85-43.9 mM), template (CTAB, 0.9-5.7 mM), effect of temperature, pH (8.6-10.8), stirring speed (100-400 rpm), and, most importantly, the mode of addition of TEOS with GNRs have been discussed. Studies with thick, porous silica coated GNRs simplify the highest ever reported surface area (1100 m(2)/g) and cargo capacity (57%) with better product yield (g/batch). First and foremost, we report a highly scalable (more than 500 mL) and rapid direct deposition of an ordered MS shell around GNRs. These engineered core-shell nanoparticles demonstrate X-ray contrast property, synergistic photothermal-chemotherapeutics, and imaging of tumor cell (96% cell death) due to released fluorescent anticancer drug molecules and photothermal effect (52 degree celsius) of embedded GNRs. A deeper insight into their influence on the architectural features and superior theranostics performances has been illustrated in detail. Hence, these findings indicate the potential impact of individual GMS for image guided combination therapeutics of cancer.

10aCombinationTherapy10aContrast Agent10aCore-ShellStructure10aGoldNanorods10aImaging10aMesoporous silica10aNanoparticles10aTheranosticsIntervention1 aPrasad, Rajendra1 aSelvaraj, Kaliaperumal uhttps://library.ncl.res.in/content/effective-distribution-gold-nanorods-ordered-thick-mesoporous-silica-choice-noninvasive