02326nas a2200277   4500008004100000022001400041245011600055210006900171260010600240300001400346490000700360520125500367653002201622653002701644653002401671653002701695653002901722100002001751700002101771700002601792700002201818700002601840700002401866700002601890856013201916       2012                        eng d  a0960-894X00aHybrid molecules of carvacrol and benzoyl urea/thiourea with potential applications in agriculture and medicine0 aHybrid molecules of carvacrol and benzoyl ureathiourea with pote  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a5550-55540 v223 a<p>Benzoyl phenyl urea, a class of insect growth regulator's acts by inhibiting chitin synthesis. Carvacrol, a naturally occurring monoterpenoid is an effective antifungal agent. We have structurally modified carvacrol (2-methyl-5-[1-methylethyl] phenol) by introducing benzoylphenyl urea linkage. Two series of benzoylcarvacryl thiourea (BCTU, 4a-f) and benzoylcarvacryl urea (BCU, 5a-f) derivatives were prepared and characterized by elemental analysis, IR, H-1 and C-13 NMR and Mass spectroscopy. Derivatives 4b, 4d, 4e, 4f and 5d, 5f showed comparable insecticidal activity with the standard BPU lufenuron against Dysdercus koenigii. BCTU derivatives 4c, 4e and BCU 5c showed good antifungal activity against phytopathogenic fungi viz. Magnaporthe grisae, Fusarium oxysporum, Dreschlera oryzae; food spoilage yeasts viz. Debaromyces hansenii, Pichia membranifaciens; and human pathogens viz. Candida albicans and Cryptococcus neoformans. Compounds 5d, 5e and 5f showed potent activity against human pathogens. Moderate and selective activity was observed for other compounds. All the synthesized compounds were non-haemolytic. These compounds have potential application in agriculture and medicine. (C) 2012 Elsevier Ltd. All rights reserved.</p>10aAntifungal agents10aBenzoyl carvacryl urea10aBenzoyl phenyl urea10aCrop protection agents10aInsect growth regulators1 aPete, Umesh, D.1 aZade, Chetan, M.1 aBhosale, Jitendra, D.1 aTupe, Santosh, G.1 aChaudhary, Preeti, M.1 aDikundwar, Amol, G.1 aBendre, Ratnamala, S.  uhttps://library.ncl.res.in/content/hybrid-molecules-carvacrol-and-benzoyl-ureathiourea-potential-applications-agriculture-and-0