01330nas a2200157   4500008004100000022001400041245014200055210006900197260010600266300001400372490000700386520060100393100002400994700002501018856012901043       2012                        eng d  a0957-416600aEnantioselective synthesis of the essential oil and pheromonal component ar-himachalene by a chiral pool and chirality induction approach0 aEnantioselective synthesis of the essential oil and pheromonal c  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a1410-14150 v233 a<p>The enantioselective synthesis of both isomers of ar-himachalene has been achieved starting from enantiomerically pure citronellal and p-methyl alpha-methyl styrene as an application of a chiral pool and chirality induction approach, respectively. The key reactions involved in the synthesis include the Sharpless asymmetric dihydroxylation for the induction of chirality at benzylic carbon bearing the methyl group and the use of a hypervalent iodine reagent or trimethylsilyldiazomethane (TMSCHN2) for the six to seven membered ring expansion. (C) 2012 Elsevier Ltd. All rights reserved.</p>1 aChavan, Subhash, P.1 aKhatod, Harshali, S.  uhttps://library.ncl.res.in/content/enantioselective-synthesis-essential-oil-and-pheromonal-component-ar-himachalene-chiral-001621nas a2200181   4500008004100000022001400041245018100055210006900236260011000305300001600415490000600431520079500437100002401232700002501256700001501281700001701296856012601313       2016                        eng d  a2046-206900aExploration of the diastereoselectivity in an unusual Grignard reaction and its application towards the synthesis of styryl lactones 7-epi-(+)-goniodiol and 8-epi-(-)-goniodiol0 aExploration of the diastereoselectivity in an unusual Grignard r  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a50721-507250 v63 a<p>An unusual diastereoselective Grignard reaction is explored, where the Grignard reagents are derived from 1,n-dihaloalkanes. A steric bias due to the presence of a quaternary centre adjacent to the acetonide ester at the benzylic position is responsible for the formation of an intramolecularly reduced product in almost quantitative yield. This steric hindrance is responsible for the diastereoselectivity observed with a variety of aromatic as well as aliphatic esters. The unusual Grignard reaction furnishes long chain secondary alcohols possessing a terminal olefin, which are synthetically important intermediates. As an application of this method, the diastereoselective synthesis of styryl lactones viz. 7-epi-(+)-goniodiol (29) and 8-epi(-)-goniodiol (30) has been achieved.</p>1 aChavan, Subhash, P.1 aKhatod, Harshali, S.1 aDas, Tamal1 aVanka, Kumar  uhttps://library.ncl.res.in/content/exploration-diastereoselectivity-unusual-grignard-reaction-and-its-application-towards01054nas a2200145   4500008004100000245012200041210006900163260000800232300001400240490000700254520047300261100002400734700002500758856012500783       2017                        eng d00aApplication of unusual grignard reaction for the stereoselective synthesis of antidepressant drug (R)-(-)-venlafaxine0 aApplication of unusual grignard reaction for the stereoselective  cMAR  a1410-14180 v493 aAn enantioselective synthesis of antidepressant drug (R)-(-)-venlafaxine is accomplished as an application of recently explored unusual Grignard reaction. An innovative method for the generation of chirality at extremely reactive benzylic center along with determination of absolute stereochemistry has been discussed. The key steps involved in the synthesis include Sharpless asymmetric dihydroxylation for the induction of chirality and an unusual Grignard reaction.1 aChavan, Subhash, P.1 aKhatod, Harshali, S.  uhttps://library.ncl.res.in/content/application-unusual-grignard-reaction-stereoselective-synthesis-antidepressant-drug-r