02492nas a2200253   4500008004100000022001400041245012000055210006900175260011000244300001600354490000700370520154000377100001901917700001401936700001801950700002001968700001901988700001802007700002002025700002202045700002402067700002102091856012602112       2012                        eng d  a0959-942800aPorous ZnO nanorod for targeted delivery of doxorubicin: in vitro and in vivo response for therapeutic applications0 aPorous ZnO nanorod for targeted delivery of doxorubicin in vitro  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcDEC  a24145-241540 v223 a<p>Cancer cell specific targeted delivery (TDD) by porous nanocarrier is on a high role. Here in a simple route for the synthesis of porous ZnO nanorods (ZnO) has been demonstrated. ZnO expressed very high surface area of 305.14 m(2) g(-1) (S-BET) and uniformly distributed pores of 5 nm. In continuation ZnO has been fabricated with 3-aminophosphonic acid followed by folic acid to yield folate conjugated porous ZnO nanorod (ZnO-FA). High surface area, uniformly distributed pores on its surface make the nanocarrier suitable for high drug loading (88%) of the anticancer drug doxorubicin (DOX). A pH triggered drug release was observed with minimum release in pathophysical conditions. In vitro efficacy of DOX loaded ZnO-FA (ZnO-FA-DOX) has been evaluated against breast cancer cells MDA-MB-231, which is not possible alone by DOX or ZnO-FA. Targeted scaffold with pendant -NH2 group has been covalently bonded with fluorescent dye (RITC) for cellular uptake and imaging studies in MDA-MB-231 cells; the possible pathway for cancer regression has also been evaluated. Even in vivo acute and intravenous toxicological evaluation on murine model system complemented biocompatibility of ZnO-FA in TDD. All together we have collaged a template free synthesis of porous ZnO nanorod, successful targeting on to cancer cells, high drug loading, pH triggered drug release, in vitro efficacy of ZnO-FA-DOX against MDA-MB-231 cells and in vivo compatibility as well. We envisioned the future prospect of porous ZnO nanostructures in TDD.</p>1 aMitra, Shouvik1 aSubia, B.1 aPatra, Prasun1 aChandra, Sourov1 aDebnath, Nitai1 aDas, Sumistha1 aBanerjee, Rahul1 aKundu, Subhas, C.1 aPramanik, Panchanan1 aGoswami, Arunava  uhttps://library.ncl.res.in/content/porous-zno-nanorod-targeted-delivery-doxorubicin-vitro-and-vivo-response-therapeutic-001311nas a2200205   4500008004100000022001400041245006900055210006900124260011000193300001600303490000600319520055600325100001900881700002000900700001700920700002000937700002400957700002100981856010301002       2012                        eng d  a2046-206900aRapid microwave synthesis of fluorescent hydrophobic carbon dots0 aRapid microwave synthesis of fluorescent hydrophobic carbon dots  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a12129-121310 v23 a<p>Fluorescent hydrophobic carbon dots (HCDs) have been fabricated from a poloxamer by a simple microwave assisted process within a few minutes for the first time. Small and distinct spherical HCDs emitted bright blue and green fluorescent light depending upon the excitation wavelength and were dispersed easily in a wide variety of organic solvents. HCDs exhibited excellent water resistant behavior with a contact angle of similar to 122 degrees enforcing good hydrophobic character which will be quite useful in potential surface applications.</p>1 aMitra, Shouvik1 aChandra, Sourov1 aKundu, Tanay1 aBanerjee, Rahul1 aPramanik, Panchanan1 aGoswami, Arunava  uhttps://library.ncl.res.in/content/rapid-microwave-synthesis-fluorescent-hydrophobic-carbon-dots-0