01410nas a2200181   4500008004100000022001400041245007100055210006900126260011000195300001600305490000700321520069700328100002701025700002401052700003501076700002001111856009701131       2013                        eng d  a1359-734500aTetrazine templated method for the synthesis of ternary conjugates0 aTetrazine templated method for the synthesis of ternary conjugat  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP  a10808-108100 v493 a<p>Conjugation is an important reaction that enables coupling of molecules. Many protocols exist for the synthesis of binary conjugates from two different molecules or for the polyvalent display of a singlemolecule. There aren'tmanymethods for the synthesis of ternary conjugates. However, methods for ternary conjugation are important for understanding the interplay of interactions between three biomolecules (or any three molecules per se). A strategy for ternary bioconjugation using inverse electron demand Diels-Alder reaction with tetrazine is studied. Ternary conjugation was demonstrated by the reaction of a model glyco-peptide binary conjugate with a fluorescent tagged olefin.</p>1 aRao, Boddu, Venkateswa1 aDhokale, Snehal, A.1 aRajamohanan, Pattuparambil, R.1 aHotha, Srinivas  uhttps://library.ncl.res.in/content/tetrazine-templated-method-synthesis-ternary-conjugates-0