01725nas a2200277   4500008004100000022001400041245013000055210006900185260010600254300001200360490000700372520065700379653002201036653002801058653002701086653002201113100002201135700002601157700001901183700002901202700002401231700002301255700002401278700001901302856012601321       2013                        eng d  a0960-894X00aOne pot solvent free synthesis and in vitro antitubercular screening of 3-aracylphthalides against mycobacterium tuberculosis0 aOne pot solvent free synthesis and in vitro antitubercular scree  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a711-7140 v233 a<p>One pot synthesis of 3-Aracylphthalide was accomplished in good yield by reacting 2-carboxy benzaldehyde with various aromatic methyl ketones in presence of methane sulphonic acid. Various phthalides thus obtained were characterized with spectral techniques. These phthalides were subjected to in vitro antitubercular screening against Mycobacterium tuberculosis H37Ra (MTB) by using XRMA protocol. Among the phthalides screened, four exhibited half maximal inhibitory concentration (IC50) in the range of 0.81-1.24 mu g/ml thereby providing potential lead compounds for future drug discovery studies. (c) 2012 Elsevier Ltd. All rights reserved.</p>10a3-Aracylphthalide10aAntitubercular activity10aMethane sulphonic acid10aOne pot synthesis1 aLimaye, Rohan, A.1 aKumbhar, Virendra, B.1 aNatu, Arun, D.1 aParadkar, Madhusudan, V.1 aHonmore, Varsha, S.1 aChauhan, Rubia, R.1 aGample, Suvarna, P.1 aSarkar, Dhiman  uhttps://library.ncl.res.in/content/one-pot-solvent-free-synthesis-and-vitro-antitubercular-screening-3-aracylphthalides-0