01433nas a2200265   4500008004100000022001400041245011900055210006900174260010600243300001400349490000700363520042300370653000600793653001500799653002400814653002500838653003000863653002900893100002600922700002100948700002200969700002400991700002501015856012701040       2006                        eng d  a0040-403900aStereoselective syntheses of unnatural steroidal C(20R) aldehydes by ionic hydrogenation of C-20 tertiary alcohols0 aStereoselective syntheses of unnatural steroidal C20R aldehydes   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a9343-93470 v473 a<p>Syntheses of three unnatural steroidal C(20R) aldehydes have been realised from 16-dehydropregnenol one acetate. The salient feature of the synthesis is the ionic hydrogenation of C-20 tertiary alcohols leading to the formation of the C(20R) unnatural isomer with complete stereoselectivity. Oxidative hydrolysis of the dithiane moiety furnished the C(20R) aldehydes. (c) 2006 Elsevier Ltd. All rights reserved.</p>10a110a3-dithiane10aionic hydrogenation10aoxidative hydrolysis10astereoselective synthesis10aunnatural C-20 aldehydes1 aShingate, Bapurao, B.1 aHazra, Braja, G.1 aPore, Vandana, S.1 aGonnade, Rajesh, G.1 aBhadbhade, Mohan, M.  uhttps://library.ncl.res.in/content/stereoselective-syntheses-unnatural-steroidal-c20r-aldehydes-ionic-hydrogenation-c-20-002379nas a2200385   4500008004100000022001400041245010600055210006900161260010600230300001400336490000700350520105700357653000601414653000601420653002801426653001501454653002201469653002101491653002501512653002901537653001901566653002401585100002601609700002401635700001901659700002201678700001901700700002701719700002401746700002401770700002101794700002601815700002601841856012601867       2009                        eng d  a0968-089600aExploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors0 aExploration of click reaction for the synthesis of modified nucl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a2433-24400 v173 a<p>Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked uridine derivatives 19a-19g and 21a-21g was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of 5'-azido-5'-deoxy-2',3'-O-(1-methylethylidene) uridine (17) with propargylated ether of phenols 18a-18g and propargylated esters 20a-20g. Structure of one of the representative compound 19d was unambiguously confirmed by X-ray crystallography. Chitin synthase inhibition study of all these compounds 19a-19g and 21a-21g was carried out to develop antifungal strategy. Compounds 19d, 19e, 19f, and 21f were identified as potent chitin synthase inhibitors by comparing with nikkomycin. Compounds 19a, 19b, 19c, 19d, 21a, and 21b showed good antifungal activity against human and plant pathogens. Compounds 19a, 19b, 19f, 21c, 21f, and 21g were identified as lead chitin synthase inhibitors for further modi. cations by comparing results of inhibition of growth, % germ tube formation and chitin synthase activity. (C) 2009 Elsevier Ltd. All rights reserved.</p>10a110a210a3-dipolar cycloaddition10a3-Triazole10a4-Disubstituted-110a5 `-Azidouridine10aAntifungal compounds10aChitin synthase activity10aClick reaction10aUridine nucleosides1 aChaudhary, Preeti, M.1 aChavan, Sayalee, R.1 aShirazi, Fazal1 aRazdan, Meenakshi1 aNimkar, Prachi1 aMaybhate, Shailaja, P.1 aLikhite, Anjali, P.1 aGonnade, Rajesh, G.1 aHazra, Braja, G.1 aDeshpande, Mukund, V.1 aDeshpande, Sunita, R.  uhttps://library.ncl.res.in/content/exploration-click-reaction-synthesis-modified-nucleosides-chitin-synthase-inhibitors-001400nas a2200241   4500008004100000022001400041245014000055210006900195260010600264300001400370490000700384520047100391653000600862653001900868653003000887653001600917653001800933653001500951100001800966700002400984700002801008856012201036       2010                        eng d  a0040-402000aSynthesis, resolution, and applications of 3-amino-2,2-dimethy1-1,3-diphenylpropan-1-ol, a conformationally restricted 1,3-aminoalcohol0 aSynthesis resolution and applications of 3amino22dimethy113diphe  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUL  a5036-50410 v663 a<p>Efficient synthetic routes to both syn and anti diastereomers of a conformationally restricted 1,3-aminoalcohol were devised. Resolution of the aminoalcohols was accomplished through diastereomeric salt with R-(-)-O-acetyl mandelic acid. These aminoalcohols were examined as ligands for two standard reactions, namely, enantioselective addition of Et(2)Zn to aldehydes and reduction of prochiral ketones with BH(3). (C) 2010 Elsevier Ltd. All rights reserved.</p>10a110a3-Aminoalcohol10aAldol-Tishchenko reaction10aDiethylzinc10aOxazaborinane10aResolution1 aPatil, M., N.1 aGonnade, Rajesh, G.1 aJoshi, Navalkishore, N.  uhttps://library.ncl.res.in/content/synthesis-resolution-and-applications-3-amino-22-dimethy1-13-diphenylpropan-1-ol-001296nas a2200253   4500008004100000022001400041245012900055210006900184260000900253300001400262490000600276520044900282653000600731653002500737653001800762653002400780653002400804653001100828100001700839700002400856700002400880700001500904856012300919       2021                        eng d  a2365-654900aAcid mediated sulfonylation of para-quinone methides with tosylmethyl isocyanides for the synthesis of diarylmethyl sulfones0 aAcid mediated sulfonylation of paraquinone methides with tosylme  cJUL   a7158-71610 v63 aAn efficient, hydrochloric acid promoted reaction for the synthesis of diarylmethyl sulfones has been developed via unprecedented 1, 6-conjugate addition reaction of tosylmethyl isocyanide (TosMIC) with para-quinone methides.This catalyst free reaction provides various diarylmethyl sulfones in good to excellent yields in an operationally simple method under metal free conditions. Further transformations of the productsare also demonstrated.10a110a6-Conjugate addition10aaromatization10aDiarylmethylsulfone10apara-Quinonemethide10aTosMIC1 aKumar, Pawan1 aKale, Someshwar, B.1 aGonnade, Rajesh, G.1 aDas, Utpal  uhttps://library.ncl.res.in/content/acid-mediated-sulfonylation-para-quinone-methides-tosylmethyl-isocyanides-synthesis