01646nas a2200229 4500008004100000022001400041245010700055210006900162260000800231300001400239490000700253520085700260653001901117653002101136653001901157653002701176653001401203100002201217700002401239700002301263856013001286 2020 eng d a1433-785100aCrystal-to-crystal synthesis of helically ordered polymers of trehalose by topochemical polymerization0 aCrystaltocrystal synthesis of helically ordered polymers of treh cFEB a2897-29030 v593 a

The synthesis of crystalline helical polymers of trehalose via topochemical azide-alkyne cycloaddition (TAAC) of a trehalose-based monomer is presented. An unsymmetrical trehalose derivative having azide and alkyne crystallizes in two different forms having almost similar packing. Upon heating, both the crystals undergo TAAC reaction to form crystalline polymers. Powder X-ray diffraction (PXRD) studies revealed that the monomers in both the crystals polymerize in a crystal-to-crystal fashion; circular dichroism (CD) studies of the product crystals revealed that the formed polymer is helically ordered. This solvent-free, catalyst-free polymerization method that eliminates the tedious purification of the polymeric product exemplifies the advantage of topochemical polymerization reaction over traditional solution-phase polymerization.

10aClick reaction10ahelical polymers10apolysaccharide10atopochemical reactions10atrehalose1 aHema, Kuntrapakam1 aGonnade, Rajesh, G.1 aSureshan, Kana, M. uhttps://library.ncl.res.in/content/crystal-crystal-synthesis-helically-ordered-polymers-trehalose-topochemical-polymerization