02006nas a2200217 4500008004100000022001400041245011000055210006900165260007300234300001200307490000700319520118700326653001301513653002501526653002701551653002001578653001801598100002101616700002001637856013101657 2012 eng d a0141-813000aGlycolic acid-g-chitosan-gold nanoflower nanocomposite scaffolds for drug delivery and tissue engineering0 aGlycolic acidgchitosangold nanoflower nanocomposite scaffolds fo aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR a878-8830 v503 a

This paper reports a simple novel method for the synthesis of flower like gold nanoparticle (three dimensional branched nanoparticle) with >30 tips, under controlled temperature condition. Formation of flower like Au nanoparticle was confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and gold nanoflower (AuNF) in controlled drug delivery and tissue engineering applications. The drug loaded novel nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Grafting of glycolic acid to the chitosan and incorporation of drug were evaluated by Fourier transform infrared spectroscopy (FTIR). The nanohybrid scaffolds were found to be stable towards the pH of the medium. The cell viability study shows that prepared nanohybrid scaffolds are biocompatible. Gold nanoflowers were found to control the drug release rate in the buffer solution (pH 7.4). Therefore, for the glycolic acid grafted chitosan based system, gold nanoflowers are the viable additive for drug delivery. (C) 2011 Elsevier B.V. All rights reserved.

10aChitosan10aDrug delivery system10aGlycolic acid grafting10aGold nanoflower10aNanocomposite1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttps://library.ncl.res.in/content/glycolic-acid-g-chitosan-gold-nanoflower-nanocomposite-scaffolds-drug-delivery-and-tissue-002030nas a2200217 4500008004100000022001400041245011300055210006900168260007300237300001000310490000700320520120200327653001901529653001301548653001801561653002701579653003301606100002101639700002001660856013201680 2012 eng d a0141-813000aGlycolic acid-g-chitosan-Pt-Fe3O4 nanoparticles nanohybrid scaffold for tissue engineering and drug delivery0 aGlycolic acidgchitosanPtFe3O4 nanoparticles nanohybrid scaffold  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUL a76-820 v513 a

This work presents the potential use of novel nanohybrid based on chitosan-g-glycolic acid and Pt-Fe3O4 composite nanoparticles in drug delivery and tissue engineering applications. The Pt-Fe3O4 hybrid nanoparticles are prepared by thermal decomposition of H2PtCl6 center dot 6H(2)O at high temperature. The prepared nanoparticles were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and physical property measurement system (PPMS). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and Pt-Fe3O4 hybrid nanoparticles in controlled drug delivery applications. The drug loaded nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Drug loading and grafting of chitosan was characterized by Fourier transform infrared spectroscopy (FTIR). The cell proliferation also shows that the prepared nanohybrids are biocompatible. The nanohybrid was found to be stable regardless of pH of the medium. Therefore, Pt-Fe3O4 hybrid nanoparticles are viable additive for sustained drug delivery and it could be applied in the field of biomedical. (c) 2012 Elsevier B.V. All rights reserved.

10aCell viability10aChitosan10adrug delivery10aGlycolic acid grafting10aPt-Fe3O4 hybrid nanoparticle1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttps://library.ncl.res.in/content/glycolic-acid-g-chitosan-pt-fe3o4-nanoparticles-nanohybrid-scaffold-tissue-engineering-and-002162nas a2200205 4500008004100000022001400041245011500055210006900170260007300239300001200312490000700324520132300331653003401654653003601688653002501724653004101749100002101790700002001811856012501831 2013 eng d a0141-813000aGlycolic acid functionalized chitosan-Au-Fe3O4 hybrid nanoparticle based nanohybrid scaffold for drug delivery0 aGlycolic acid functionalized chitosanAuFe3O4 hybrid nanoparticle aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAR a244-2490 v543 a

The research on biomedical applications of nanoparticles has seen an upsurge in recent years due to their unique capabilities in treatment of ailments. The present paper reports the synthesis of Au-Fe3O4 hybrid nanoparticles. The formation of these nanoparticles was confirmed by transmission electron microscopy (TEM) and physical property measurement system (PPMS). Next step of this paper reveals potential use of novel hybrid of chitosan-g-glycolic acid and Au-Fe3O4 hybrid nanoparticles in controlled drug delivery and tissue engineering applications. Grafting of glycolic acid and drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of pH of the medium and play a key role in cell adhesion, proliferation and migration. Au-Fe3O4 hybrid nanoparticles reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Au-Fe3O4 hybrid nanoparticles are viable additive for formulating sustained drug delivery systems based on glycolic acid grafted chitosan. The cell proliferation profile also shows that prepared nanohybrid is biocompatible providing suitable substrates for tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.

10aAu-Fe3O4 hybrid nanoparticles10aChitosan Glycolic acid grafting10aDrug delivery system10aPhysical property measurement system1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttps://library.ncl.res.in/content/glycolic-acid-functionalized-chitosan-au-fe3o4-hybrid-nanoparticle-based-nanohybrid-001757nas a2200157 4500008004100000022001400041245015200055210006900207260005700276300001400333490000700347520107700354100002101431700002001452856012701472 2013 eng d a0022-246100aGlycolic acid-functionalized chitosan-Co3O4-Fe3O4 hybrid magnetic nanoparticles-based nanohybrid scaffolds for drug-delivery and tissue engineering0 aGlycolic acidfunctionalized chitosanCo3O4Fe3O4 hybrid magnetic n a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcFEB a1524-15320 v483 a

In the present work, Co3O4 was prepared by hydrothermal process, which is further used for the synthesis of Co3O4-Fe3O4 hybrid nanoparticles. The formation of Co3O4-Fe3O4 nanoparticles was investigated by transmission electron microscopy and physical property measurement system. In the next step, the drug-loaded novel nanohybrid porous scaffold based on chitosan-g-glycolic acid and Co3O4-Fe3O4 nanoparticle was prepared by freeze drying technique. The grafting of glycolic acid on chitosan drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of the pH of the medium and play an important role in cell adhesion, proliferation, and migration. Co3O4-Fe3O4 hybrid nanoparticles' reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Co3O4-Fe3O4 hybrid nanoparticles are viable additives for formulating sustained drug delivery systems and could be applied in the field of biomaterials.

1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttps://library.ncl.res.in/content/glycolic-acid-functionalized-chitosan-co3o4-fe3o4-hybrid-magnetic-nanoparticles-based-001618nas a2200181 4500008004100000022001400041245006400055210006300119260000900182300001200191490000600203520104000209100002101249700002001270700002301290700002801313856009501341 2018 eng d a2045-985800aChitosan-based bionanocomposites for biomedical application0 aChitosanbased bionanocomposites for biomedical application cDEC  a219-2270 v73 aNatural polymers have greatly impacted the advancement of modern medicine. Natural polymer-based biomaterials are biodegradable. A significant advantage of natural polymers is that they can be broken down and removed from the body after they have served their function. A wide range of novel biomaterials from natural polymers has been investigated to meet new challenges in medical science. Chitosan is one of the natural polymers which have been widely used in the biomedical field. Nanotechnology is one of the most popular areas of current research. In the area of nanotechnology, polymer and metal/metal oxide nanoparticle matrix-based nanocomposites have generated a significant amount of attention in the recent literature. These bionanocomposites have wide-ranging applications in drug delivery and tissue engineering. This paper discusses polymer-metal/metal oxide nanoparticle matrix-based nanocomposite biomaterials and their applications in the biomedical field - that is, drug delivery and tissue engineering applications.1 aKumari, Sangeeta1 aSingh, Raj, Pal1 aChavan, Nayaku, N.1 aAnnamalai, Pratheep, K. uhttps://library.ncl.res.in/content/chitosan-based-bionanocomposites-biomedical-application02087nas a2200241 4500008004100000245011400041210006900155260000800224300000900232490000700241520123200248653001301480653002401493653003401517653002901551653003101580100002101611700002001632700002301652700002401675700001901699856012701718 2021 eng d00aCharacterization of a novel nanocomposite film based on functionalized chitosan-Pt-Fe3O4 hybrid nanoparticles0 aCharacterization of a novel nanocomposite film based on function cMAY a12750 v113 a

The development of organic-inorganic hybrids or nanocomposite films is increasingly becoming attractive in light of their emerging applications. This research focuses on the formation of a unique nanocomposite film with enhanced elasticity suitable for many biomedical applications. The physical property measurement system and transmission electron microscopy were used to analyze Pt-Fe3O4 hybrid nanoparticles. These nanohybrids exhibited magnetic effects. They were further exploited to prepare the nanocomposite films in conjunction with a chitosan-g-glycolic acid organic fraction. The nanocomposite films were then examined using standard techniques: thermogravimetric analysis, X-ray diffraction, Fourier transform infrared spectroscopy, and atomic force microscopy. Tensile strength testing demonstrated a significantly greater elastic strength of these nanocomposite films than pure chitosan films. The water absorption behavior of the nanocomposites was evaluated by measuring swelling degree. These nanocomposites were observed to have substantially improved physical properties. Such novel nanocomposites can be extended to various biomedical applications, which include drug delivery and tissue engineering.

10aChitosan10ananocomposite films10aPt-Fe3O4 hybrid nanoparticles10atensile strength testing10aThermogravimetric analysis1 aKumari, Sangeeta1 aSingh, Raj, Pal1 aChavan, Nayaku, N.1 aSahi, Shivendra, V.1 aSharma, Nilesh uhttps://library.ncl.res.in/content/characterization-novel-nanocomposite-film-based-functionalized-chitosan-pt-fe3o4-hybrid01174nas a2200217 4500008004100000022001400041245016400055210006900219260000800288490000700296520037700303100002100680700002100701700001700722700002100739700001700760700001700777700002100794700002000815856012100835 2025 eng d a1359-734500aZn(ii)-metallo-photoantibiotics: experimental and computational approach identifying a therapeutic role for antibacterial and antibiofilm applications0 aZnsciiscmetallophotoantibiotics experimental and computational a cJUL0 v613 a

The antibacterial profiles of curcumin-based novel Zn(ii)-metallo-photoantibiotics against E. coli and B. subtilis are reported. In silico studies indicated their ROS generation capacity and binding interaction with bacterial proteins. Therapeutic results indicated the advantages of these Zn(ii)-metallo-photoantibiotics in antibacterial photodynamic therapy.

1 aKushwaha, Rajesh1 aKumari, Sangeeta1 aMishra, Arya1 aUpadhyay, Anjali1 aRai, Archana1 aNayak, Malay1 aMukherjee, Sudip1 aBanerjee, Samya uhttps://library.ncl.res.in/content/znii-metallo-photoantibiotics-experimental-and-computational-approach-identifying