01728nas a2200289   4500008004100000022001400041245009000055210006900145260010600214300001400320490000700334520072600341653001301067653001801080653001701098653001701115653002101132653001701153653002501170653001401195100002801209700002701237700002201264700001601286700002101302856011501323       2009                        eng d  a0960-894X00aSynthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents0 aSynthesis and in vitro study of 14aryl14Hdibenzoajxanthenes as c  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a5590-55930 v193 a<p>A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of beta-naphthol with aryl aldehydes catalysed by TaCl(5) under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl-14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues. Synthesized compound 30 showed IC(50) of 37.9 and 41.3 mu M against Colo-205 and 502713, respectively, whereas 3g showed IC(50) of 41.9 mu M against Colo-205. (C) 2009 Elsevier Ltd. All rights reserved.</p>10aAldehyde10abeta-Naphthol10acondensation10aCytotoxicity10aOne-pot reaction10aSolvent-free10aTantalum(V) chloride10aXanthenes1 aBhattacharya, Asish, K.1 aRana, Kalpeshkumar, C.1 aMujahid, Mohammad1 aSehar, Irum1 aSaxena, Ajit, K.  uhttps://library.ncl.res.in/content/synthesis-and-vitro-study-14-aryl-14h-dibenzoajxanthenes-cytotoxic-agents-0