02128nas a2200301   4500008004100000022001400041245008500055210006900140260007600209300001200285490000700297520110700304653000601411653000601417653001601423653000601439653003201445653002401477653002701501653001901528100002201547700002701569700003501596700001801631700003401649700002601683856011701709       2008                        eng d  a1747-027700aAntibacterial activity of synthesized 2,4,5-trisubstituted imidazole derivatives0 aAntibacterial activity of synthesized 245trisubstituted imidazol  aCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAbWILEY-BLACKWELLcSEP  a197-2040 v723 a<p>Some novel chemically synthesized 2,4,5-trisubstituted imidazoles from aryl aldehydes and 1,2-diketones or alpha-hydroxyketone were screened against eight different human pathogenic bacteria and fungi. Seven compounds were found to be active against different bacteria. These compounds showed variation in activity and were found to be active against Gram-positive as well as Gram-negative bacteria. Compound 4-(4,5-diphenyl-1H-imidazol-2-yl)-phenol, 3d was the only compound which showed activity against Klebsiella pneumoniae while rest of the compounds did not show significant activity against this micro-organism. Minimum inhibitory concentrations of the compounds were in the range of 0.50 to 6.1 mu g/mL and minimum bactericidal concentration ranges from 1.11 to 12.9 mu g/mL. The candidature of active compounds to be an effective and novel drug was examined based on Lipinski's rule of Five which explained ClogP, LogS, H-bond acceptors, H-Bond donors and rotational bonds. Compounds 3a-d and 3f satisfies Lipinski's rule of Five and could be proposed as potent new antibacterial drugs.</p>10a110a210a2-Diketones10a410a5-trisubstituted imidazoles10aalpha-hydroxyketone10aantibacterial activity10aaryl aldehydes1 aKhan, Mohd, Sajid1 aSiddiqui, Shafi, Ahmad1 aSiddiqui, Mohammad, Shaik Rafi1 aGoswami, Usha1 aSrinivasan, Kumar, Venkatrama1 aKhan, Mohammad, Islam  uhttps://library.ncl.res.in/content/antibacterial-activity-synthesized-245-trisubstituted-imidazole-derivatives-002314nas a2200217   4500008004100000022001400041245014400055210006900199260009100268300001100359490000600370520141400376100002201790700002301812700001801835700002701853700003101880700003401911700002201945856012901967       2013                        eng d  a1932-620300aDesign, synthesis, evaluation and thermodynamics of 1-substituted pyridylimidazo[1,5-a]pyridine derivatives as cysteine protease inhibitors0 aDesign synthesis evaluation and thermodynamics of 1substituted p  a1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USAbPUBLIC LIBRARY SCIENCEcAUG  ae699820 v83 a<p>Targeting papain family cysteine proteases is one of the novel strategies in the development of chemotherapy for a number of diseases. Novel cysteine protease inhibitors derived from 1-pyridylimidazo[1,5-a]pyridine representing pharmacologically important class of compounds are being reported here for the first time. The derivatives were initially designed and screened in silico by molecular docking studies against papain to explore the possible mode of action. The molecular interaction between the compounds and cysteine protease (papain) was found to be very similar to the interactions observed with the respective epoxide inhibitor (E-64c) of papain. Subsequently, compounds were synthesized to validate their efficacy in wet lab experiments. When characterized kinetically, these compounds show their K-i and IC50 values in the range of 13.75 to 99.30 mu M and 13.40 to 96.50 mu M, respectively. The thermodynamics studies suggest their binding with papain hydrophobically and entropically driven. These inhibitors also inhibit the growth of clinically important different types of Gram positive and Gram negative bacteria having MIC50 values in the range of 0.6-1.4 mu g/ml. Based on Lipinski's rule of Five, we also propose these compounds as potent antibacterial prodrugs. The most active antibacterial compound was found to be 1-(2-pyridyl)-3-(2-hydroxyphenyl)imidazo[1,5-a]pyridine (3a).</p>1 aKhan, Mohd, Sajid1 aBaig, Mohd, Hassan1 aAhmad, Saheem1 aSiddiqui, Shapi, Ahmad1 aSrivastava, Ashwini, Kumar1 aSrinivasan, Kumar, Venkatrama1 aAnsari, Irfan, A.  uhttps://library.ncl.res.in/content/design-synthesis-evaluation-and-thermodynamics-1-substituted-pyridylimidazo15-apyridine-0