02094nas a2200241   4500008004100000022001400041245009900055210006900154260008400223300001200307490000800319520120900327653001301536653001801549653002701567653001901594653002001613653002101633100001701654700003101671700002001702856013001722       2006                        eng d  a1549-329600aPreparation and characterization of novel hybrid of chitosan-g-lactic acid and montmorillonite0 aPreparation and characterization of novel hybrid of chitosanglac  aDIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USAbWILEY-LISScAUG  a372-3820 v78A3 a<p>The utilization of biopolymers and the development of organic-inorganic hybrids are ever increasing interest of material science researchers around the globe for various applications. The present attempt is intended to prepare nanocomposites of lactic acid grafted chitosan and layered silicates. Nanocomposites were prepared by dissolving chitosan and dispersing sodium montmorillonite in aqueous solution of L-lactic acid with subsequent heating and film casting. They were characterized by conventional techniques such as Fourier transform infrared spectroscopy, X-ray diffractometry, thermogravimetric analysis, energy dispersive X-ray spectroscopy, and elemental analysis. The results from polar optical and transmission electron microscopic measurements are also discussed. Sorption behavior of samples has been followed by measuring swelling degree and contact angle. The films have shown enhanced hydrophilicity when compared with polylactic acid (PLA). Issues on the interactions of polycationic chitosan with clay are also discussed. It is observed that nanocomposites are exhibiting better thermal and physical properties than neat chitosang-LA and PLA. (c) 2006 Wiley Periodicals, Inc.</p>10aChitosan10acontact angle10agraft copolymerization10aNanocomposites10apolylactic acid10awater absorption1 aDepan, Dilip1 aKumar, Annamalai, Pratheep1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/preparation-and-characterization-novel-hybrid-chitosan-g-lactic-acid-and-montmorillonite-001975nas a2200229   4500008004100000022001400041245009900055210006900154260008400223300001200307490000700319520114300326653001301469653002701482653001901509653000901528653002101537100001701558700002001575700002001595856013001615       2008                        eng d  a1552-497300aPreparation and characterization of novel hybrid of chitosan-g-PDMS and sodium montmorrilonite0 aPreparation and characterization of novel hybrid of chitosangPDM  aDIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USAbWILEY-LISScJAN  a184-1900 v843 a<p>Preparation and properties of Chitosan (CS)-clay nanocomposites grafted with polydimethyl siloxane (PDMS) with different clay ratios are herein discussed. CS is intercalated into sodium montmorrilonite and PDMS is grafted onto CS under UV irradiation. Sample films of CS intercalated into clay and grafted with PDMS were prepared by solvent casting method with varying amount of nanoclay and PDMS. They were characterized by conventional techniques such as X-ray diffractometry, fourier transform infrared spectroscopy, C-13 NMR, thermo gravimetric analysis, and differential thermal analysis. Sorption behavior of samples has been followed by measuring swelling degree and issues on the interactions of biopolymers with clay are also discussed. The water absorption of composites films reduces with an increase in the amount of incorporated clay. This is due to the barrier formation in the form of cross-linking points, which prevents water permeation into CS. The amount of adsorbed water is more, when the amount of CS exceeds the amount of PDMS. This shows high water retention capacity of CS. (c) 2007 Wiley Periodicals, Inc.</p>10aChitosan10agraft copolymerization10aNanocomposites10aPDMS10awater absorption1 aDepan, Dilip1 aKumar, Bijandra1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/preparation-and-characterization-novel-hybrid-chitosan-g-pdms-and-sodium-montmorrilonite-002154nas a2200229   4500008004100000022001400041245012600055210006900181260009900250300001100349490000600360520126800366653001301634653000901647653002301656653002601679653001901705100001701724700003101741700002001772856013201792       2009                        eng d  a1742-706100aCell proliferation and controlled drug release studies of nanohybrids based on chitosan-g-lactic acid and montmorillonite0 aCell proliferation and controlled drug release studies of nanohy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcJAN  a93-1000 v53 a<p>The present paper reveals the potential uses of novel hybrids of chitosan-g-lactic acid and sodium montmorillonite (MMT) in controlled drug delivery and tissue engineering applications. The drug-loaded novel nanohybrid films and porous scaffolds have been prepared by solvent casting and freeze-drying of the grafted polymer solution, respectively. Sodium Ibuprofen was loaded into nanohybrids of chitosan-g-lactic acid/sodium montmorillonite (CS-g-LA/MMT). Grafting of lactic acid and the drug loading were characterized by Fourier transform infrared spectroscopy. Formation of intercalated nanocomposites was confirmed by X-ray diffraction. Mechanical properties measurements have shown improvement in modulus and strength with expense of elongation by MMT reinforcement. The nanohybrids were found to be stable regardless of pH of the medium. The cell proliferation profile also shows that prepared nanohybrids are biocompatible. MMT reinforcement was found to control the drug (Ibuprofen) release rate in phosphate buffer saline solution (pH 7.4). MMT clay is therefore a viable additive for formulating sustained drug delivery systems based on lactic acid grafted chitosan. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</p>10aChitosan10aclay10aControlled release10adrug delivery systems10aNanocomposites1 aDepan, Dilip1 aKumar, Annamalai, Pratheep1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/cell-proliferation-and-controlled-drug-release-studies-nanohybrids-based-chitosan-g-lactic-002253nas a2200217   4500008004100000022001400041245014200055210006900197260006800266300001400334490000800348520139100356653003201747653002401779653001301803653002601816653003001842100001701872700002001889856012601909       2010                        eng d  a0021-899500aPreparation and characterization of novel hybrid of bio-assisted mineralized Zn-Al layered double hydroxides using chitosan as a template0 aPreparation and characterization of novel hybrid of bioassisted   a111 RIVER ST, HOBOKEN, NJ 07030 USAbJOHN WILEY & SONS INCcMAR  a3636-36440 v1153 a<p>The purpose of this study was to prepare and characterize a novel nanohybrid prepared from the template-assisted mineralization of Zn-Al Layered Double Hydroxide (LDH) onto the surface of Chitosan (CSI), with an emphasis on morphology, biocompatibitity, and its use as an efficient drug carrier agent. The as prepared LDH is highly crystalline, with platelet-like morphology and curved tactoids when nucleated onto the surface of CSI. Our results indicate that the -OH and -NH functional moieties on CSI can direct an ordered structure of LDH, due to the electrostatic interaction between biopolymer and inorganic lamellae. We have been successful to intercalate an anti-inflammatory drug, Sodium Ibuprofen (Ibu), into LDH, through conventional coprecipitation method. LDHs are endowed with great potential for delivery vector because their stacked layers lead to safe reservation of biofunctional molecules or genes, and their ion exchangeability and solubility in acidic media (pH &lt; 4) give rise to the controlled release of drug molecules. According to the cell-growth studies, LDHs are found as cell viable up to the concentration of 500 mu g/mL. This study reveals that LDH not only plays a role of a biocompatible-delivery matrix but also facilitates a significant increase in the delivery efficiency. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115:3636-3644,2010</p>10abio-assisted mineralization10acell-growth studies10aChitosan10adrug delivery systems10alayered double hydroxides1 aDepan, Dilip1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/preparation-and-characterization-novel-hybrid-bio-assisted-mineralized-zn-al-layered-001892nas a2200229   4500008004100000022001400041245013700055210006900192260009600261300001000357490000800367520100900375653001301384653002601397653001401423653002201437653001501459100001701474700001901491700002001510856013201530       2010                        eng d  a1022-136000aUltrasound-triggered release of ibuprofen from a chitosan-mesoporous silica composite - a novel approach for controlled drug release0 aUltrasoundtriggered release of ibuprofen from a chitosanmesoporo  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbInt Union Pure & Appl Chem; German Res FdncJAN  a80-880 v2873 a<p>In this work, an attempt was made to synthesize a novel Chitosan-Mesoporous silica (CS-MS) hybrid composite to design a drug delivery system based on ultrasound triggered stimuli-responsive smart release. The in-vitro drug release properties of both the Mesoporous Silica (MS) and Chitosan (CS) hybrids were investigated. Ibuprofen (Ibu) was used as a model drug. The results from powder X-Ray diffraction (XRD) patterns, and BET N(2) adsorption isotherms exhibited that MS can accommodate drug molecules into the lumen of the channels and pores. Drug release, stimulated by temperature and pH of the release media was also investigated. We studied the Ultrasound (US) triggered release of Ibu in a simulated body fluid (pH 7.4). The results exhibited that US can be used as a non-invasive technique for drug release from polymeric materials. The enhancing effect of ultrasound on drug release is due to the Cavitation effect, without causing any significant destruction on the polymer morphology.</p>10aChitosan10adrug delivery systems10aibuprofen10aMesoporous silica10aUltrasound1 aDepan, Dilip1 aSaikia, Lakshi1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/ultrasound-triggered-release-ibuprofen-chitosan-mesoporous-silica-composite-novel-approach-0