02154nas a2200229   4500008004100000022001400041245012600055210006900181260009900250300001100349490000600360520126800366653001301634653000901647653002301656653002601679653001901705100001701724700003101741700002001772856013201792       2009                        eng d  a1742-706100aCell proliferation and controlled drug release studies of nanohybrids based on chitosan-g-lactic acid and montmorillonite0 aCell proliferation and controlled drug release studies of nanohy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcJAN  a93-1000 v53 a<p>The present paper reveals the potential uses of novel hybrids of chitosan-g-lactic acid and sodium montmorillonite (MMT) in controlled drug delivery and tissue engineering applications. The drug-loaded novel nanohybrid films and porous scaffolds have been prepared by solvent casting and freeze-drying of the grafted polymer solution, respectively. Sodium Ibuprofen was loaded into nanohybrids of chitosan-g-lactic acid/sodium montmorillonite (CS-g-LA/MMT). Grafting of lactic acid and the drug loading were characterized by Fourier transform infrared spectroscopy. Formation of intercalated nanocomposites was confirmed by X-ray diffraction. Mechanical properties measurements have shown improvement in modulus and strength with expense of elongation by MMT reinforcement. The nanohybrids were found to be stable regardless of pH of the medium. The cell proliferation profile also shows that prepared nanohybrids are biocompatible. MMT reinforcement was found to control the drug (Ibuprofen) release rate in phosphate buffer saline solution (pH 7.4). MMT clay is therefore a viable additive for formulating sustained drug delivery systems based on lactic acid grafted chitosan. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</p>10aChitosan10aclay10aControlled release10adrug delivery systems10aNanocomposites1 aDepan, Dilip1 aKumar, Annamalai, Pratheep1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/cell-proliferation-and-controlled-drug-release-studies-nanohybrids-based-chitosan-g-lactic-002260nas a2200253   4500008004100000022001400041245009700055210006900152260010600221300001200327490000700339520132300346653002101669653000901690653003401699653001901733653001801752653001201770100003101782700001701813700002601830700002001856856013001876       2009                        eng d  a0079-670000aNanoscale particles for polymer degradation and stabilization-trends and future perspectives0 aNanoscale particles for polymer degradation and stabilizationtre  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a479-5150 v343 a<p>The field of nanoscience and nanotechnology is extending the applications of physics, chemistry, biology, engineering and technology into previously unapproached infinitesimal length scales. The polymer-nanoparticles/nanocomposites have been the exponentially growing field of research for developing the materials in last few decades and have been mainly focusing on the structure-property relationships and their development. Since the polymer-nanocomposites have been the staple of modern polymer industry, their durability under various environmental conditions and degradability after their service life are also essential fields of research. Thus, this article is intended to review the status of worldwide research in this aspect. Among various nanoparticulates, clay minerals and carbon nanotubes are more often used in enhancing physical, mechanical and thermal properties of polymers. In very few systems, the nano particulates have been incorporated into polymer as `nano-additives' for both purposes: degradation and stabilization of polymers. The degradation and durability of polymers is reviewed in the presence of nanoparticles/nanocomposites under different environmental conditions. Nanoparticle-induced biodegradation of polymers is also discussed. (c) 2009 Elsevier Ltd. All rights reserved.</p>10aCarbon nanotubes10aclay10aDegradation and stabilization10aNanocomposites10aNanoparticles10aPolymer1 aKumar, Annamalai, Pratheep1 aDepan, Dilip1 aTomer, Namrata, Singh1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/nanoscale-particles-polymer-degradation-and-stabilization-trends-and-future-perspectives-0