01810nas a2200253   4500008004100000022001400041245021300055210006900268260007700337300001400414520076600428653001401194653001601208653003601224653001401260653003601274653001401310100002401324700002001348700001701368700001801385700002101403856013201424       2010                        eng d  a1434-193X00aCombined experimental and density functional theory study on the Pd-mediated cycloisomerization of o-alkynylnitrobenzenes - synthesis of isatogens and their evaluation as modulators of ROS-mediated cell death0 aCombined experimental and density functional theory study on the  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcNOV  a5955-59663 a<p>Highly selective cycloisomerization of o-alkynylnitrobenzenes, leading to isatogens, has been achieved by employment of a Pd-II complex. This reaction is very general and functional-group-tolerant. The possible mechanism of this reaction was investigated with the help of DFT calculations. Three possible pathways - namely, the addition of the nitro group either in (i) 5-exo-dig or (ii) 6-endo-dig mode and (iii) halopalladation - and subsequent intramolecular events have been considered and studied in detail. These investigations revealed that pathway (i) is the favored route to isatogen formation. A preliminary screening of the available isatogens reveals the 2-alkylisatogens to be novel ROS scavengers capable of inhibiting cellular necroptosis.</p>10aAnthranil10acyclization10aDensity functional calculations10aisatogens10aNitro-alkyne cycloisomerization10aPalladium1 aRamana, Chepuri, V.1 aPatel, Pitambar1 aVanka, Kumar1 aMiao, Benchun1 aDegterev, Alexei  uhttps://library.ncl.res.in/content/combined-experimental-and-density-functional-theory-study-pd-mediated-cycloisomerization-o-000821nas a2200157   4500008004100000022001400041245007500055210006900130260011000199300001400309490000600323520018200329100002000511700002400531856010800555       2011                        eng d  a1477-052000aDivergent Pd(II) and Au(III) mediated nitroalkynol cycloisomerizations0 aDivergent PdII and AuIII mediated nitroalkynol cycloisomerizatio  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN  a7327-73340 v93 a<p>A new cycloisomerization reaction comprising the simultaneous addition of nitro and alcohol groups across C C leading to skeletally diverse small molecules is documented.</p>1 aPatel, Pitambar1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/divergent-pdii-and-auiii-mediated-nitroalkynol-cycloisomerizations-001096nas a2200157   4500008004100000022001400041245003900055210003500094260007100129300001600200490000700216520060900223100002000832700001900852856006700871       2012                        eng d  a0022-326300aTotal synthesis of (-)-isatisine A0 aTotal synthesis of isatisine A  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcDEC  a10509-105150 v773 a<p>A modular total synthesis of (-)-isatisine A is described in which four consecutive metal-mediated transformations have been employed at the final stage. These include [Pd]-catalyzed Sonogashira coupling, [Pd]-catalyzed nitroalkyne cycloisomerization leading to isatogens, and addition of indoles to isatogens using InCl3- and [Rh]-catalyzed oxidative N-heterocyclization of amino alcohol to form the key amide bond. In addition to these, the removal of the protecting groups has also been carried out in a selective fashion employing either catalytic or stoichiometric metal/metal-based reagents.</p>1 aPatel, Pitambar1 aRamana, C., V.  uhttps://library.ncl.res.in/content/total-synthesis-isatisine-001478nas a2200241   4500008004100000022001400041245013400055210006900189260010600258300001200364490000700376520053200383653003200915653002800947653002000975653001600995653001201011653002301023100002001046700002601066700001901092856012501111       2014                        eng d  a0040-402000aSynthesis of the central tricyclic core of the isatisine A: harmonious orchestration of [metal]-catalyzed reactions in a sequence0 aSynthesis of the central tricyclic core of the isatisine A harmo  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a510-5160 v703 a<p>Two sequential metal-catalyzed transformations, involving [In]-catalyzed Friedel Crafts type addition of spiroaminol carbon to indole C3 followed by [Rh]-catalyzed dehydrogenative cyclization of the resulting gamma-amino alcohol culminated in the construction of the central tricyclic core isatisine A. The overall strategy employed three easily available starting compounds and delivered the complex tricyclic core in four steps with all four steps being catalytic in nature. (C) 2013 Elsevier Ltd. All rights reserved.</p>10aDehydrogenative cyclization10aFriedel-Crafts reaction10aIndium chloride10aIsatisine A10aRhodium10aSpiro-3-indolinone1 aPatel, Pitambar1 aReddy, Narendraprasad1 aRamana, C., V.  uhttps://library.ncl.res.in/content/synthesis-central-tricyclic-core-isatisine-harmonious-orchestration-metal-catalyzed-001061nas a2200169   4500008004100000022001400041245013500055210006900190260007100259300001400330490000700344520033800351100002600689700002000715700002400735856013200759       2016                        eng d  a1523-706000aIr(III)-catalyzed carbenoid functionalization of benzamides: synthesis of N-methoxyisoquinolinediones and N-methoxyisoquinolinones0 aIrIIIcatalyzed carbenoid functionalization of benzamides synthes  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUN  a2828-28310 v183 a<p>A mild and efficient Ir(III)-catalyzed C-H carbenoid functionalization strategy has been developed to access. N-methoxyisoquinolinediones and N-methoxyisoquinolinones. The reaction proceeds efficiently in high yield at room temperature over a broad range of substrates without requirement of any additional oxidants or a base.</p>1 aPhatake, Ravindra, S.1 aPatel, Pitambar1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/iriii-catalyzed-carbenoid-functionalization-benzamides-synthesis-n-methoxyisoquinolinediones01278nas a2200169   4500008004100000022001400041245010600055210006900161260007100230300001200301490000700313520059500320100002600915700002000941700002400961856012300985       2016                        eng d  a1523-706000aIr(III)-catalyzed synthesis of isoquinoline N-oxides from aryloxime and alpha-diazocarbonyl compounds0 aIrIIIcatalyzed synthesis of isoquinoline Noxides from aryloxime   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJAN  a292-2950 v183 a<p>An efficient Ir(III)-catalyzed C-H activation and annulations of aryloxime with a-diazocarbonyl compounds has been developed for the synthesis of substituted isoquinoline N-oxides. The reaction proceeds under mild atmospheric conditions, without any external oxidants and releases N-2 and H2O as the byproducts. In addition, synthetic applications of the N-oxide products have been established by performing further functionalization. An interesting dimeric iridacyclic complex allied through a bis-silver carboxylate bridge has been isolated that efficiently catalyzed the reaction.</p>1 aPhatake, Ravindra, S.1 aPatel, Pitambar1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/iriii-catalyzed-synthesis-isoquinoline-n-oxides-aryloxime-and-alpha-diazocarbonyl-000695nas a2200193   4500008004100000022001400041245009600055210006900151260000800220300000800228490000800236100002800244700003600272700002000308700002000328700001700348700002000365856011600385       2021                        eng d  a0974-362600aSynthesis of anisotropic rod-like gold nanostructures in organic media (vol 133, 106, 2021)0 aSynthesis of anisotropic rodlike gold nanostructures in organic   cDEC  a1200 v1331 aPrasad, Bhagavatula, L.1 aSivasankaran, Prathap, Chandran1 aPatel, Pitambar1 aMalekar, Pushpa1 aMaya, V., K.1 aRamana, Chepuri  uhttps://library.ncl.res.in/content/synthesis-anisotropic-rod-gold-nanostructures-organic-media-vol-133-106-202101217nas a2200205   4500008004100000022001400041245007500055210006900130260000800199300000800207490000800215520061300223100000500836700003600841700002000877700000500897700000500902700000500907856009900912       2021                        eng d  a0974-362600aSynthesis of anisotropic rod-like gold nanostructures in organic media0 aSynthesis of anisotropic rodlike gold nanostructures in organic   cDEC  a1060 v1333 aSynthesis of anisotropic rod-like gold nanostructures was carried out in chloroform employing a modified ascorbic acid derivative as a reducing agent in the presence and absence of seed particles. The seed particles and/or the chloroaurate ions were phase transferred to the organic media using n-octadecyl amine. High-resolution transmission electron microscopy analysis clearly revealed that the anisotropic structures are single crystalline in nature. The stabilization of certain crystallographic faces of anisotropic gold nanostructures by amines is invoked to explain the formation of these structures.1 a1 aSivasankaran, Prathap, Chandran1 aPatel, Pitambar1 a1 a1 a  uhttps://library.ncl.res.in/content/synthesis-anisotropic-rod-gold-nanostructures-organic-media01552nas a2200181   4500008004100000022001400041245006700055210006700122260000800189300001400197490000700211520097800218100002101196700002001217700001701237700002401254856009201278       2021                        eng d  a1477-052000aTotal synthesis of the pseudoindoxyl class of natural products0 aTotal synthesis of the pseudoindoxyl class of natural products  cOCT  a7970-79940 v193 aThe pseudoindoxyl sub-structural motif, amongst the large set of the indole class of alkaloids, represents a unique subset of the oxygenated indole class of the alkaloid family. A majority of this class of natural products contains complex bridged/polycyclic scaffolds with interesting biological profiles. They are thus attractive synthetic targets. Starting from 1963, twenty-eight natural products having the pseudoindoxyl scaffold have been isolated, among which the synthesis of 13 natural products has been accomplished. In this review, we highlight the completed as well as the formal total synthesis of the natural products with a spiro-pseudoindoxyl ring, with a focus on their development. The challenges and the future perspective based on the recent developments in the field will also be discussed. We strongly believe that this review will not only update but also attract the attention of researchers in dealing with the synthesis of pseudoindoxyl compounds.1 aDhote, Pawan, S.1 aPatel, Pitambar1 aVanka, Kumar1 aRamana, Chepuri, V.  uhttps://library.ncl.res.in/content/total-synthesis-pseudoindoxyl-class-natural-products