02381nas a2200229   4500008004100000022001400041245008700055210006900142260005700211300001400268490000700282520156500289653003001854653002601884653001801910653002001928653002301948100001901971700002001990700002102010856012002031       2013                        eng d  a0092-824000aRealistic host-vector transmission model for describing malaria prevalence pattern0 aRealistic hostvector transmission model for describing malaria p  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcDEC  a2499-25280 v753 a<p>Malaria continues to be a major public health concern all over the world even after effective control policies have been employed, and considerable understanding of the disease biology have been attained, from both the experimental and modelling perspective. Interactions between different general and local processes, such as dependence on age and immunity of the human host, variations of temperature and rainfall in tropical and sub-tropical areas, and continued presence of asymptomatic infections, regulate the host-vector interactions, and are responsible for the continuing disease prevalence pattern. In this paper, a general mathematical model of malaria transmission is developed considering short and long-term age-dependent immunity of human host and its interaction with pathogen-infected mosquito vector. The model is studied analytically and numerically to understand the role of different parameters related to mosquitoes and humans. To validate the model with a disease prevalence pattern in a particular region, real epidemiological data from the north-eastern part of India was used, and the effect of seasonal variation in mosquito density was modelled based on local climactic data. The model developed based on general features of host-vector interactions, and modified simply incorporating local environmental factors with minimal changes, can successfully explain the disease transmission process in the region. This provides a general approach toward modelling malaria that can be adapted to control future outbreaks of malaria.</p>10aBasic reproduction number10aEnvironmental effects10aMalaria model10aPrevalence data10aStability analysis1 aMandal, Sandip1 aSinha, Somdatta1 aSarkar, Ram, Rup  uhttps://library.ncl.res.in/content/realistic-host-vector-transmission-model-describing-malaria-prevalence-pattern-0