01410nas a2200181 4500008004100000022001400041245007100055210006900126260011000195300001600305490000700321520069700328100002701025700002401052700003501076700002001111856009701131 2013 eng d a1359-734500aTetrazine templated method for the synthesis of ternary conjugates0 aTetrazine templated method for the synthesis of ternary conjugat aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a10808-108100 v493 a

Conjugation is an important reaction that enables coupling of molecules. Many protocols exist for the synthesis of binary conjugates from two different molecules or for the polyvalent display of a singlemolecule. There aren'tmanymethods for the synthesis of ternary conjugates. However, methods for ternary conjugation are important for understanding the interplay of interactions between three biomolecules (or any three molecules per se). A strategy for ternary bioconjugation using inverse electron demand Diels-Alder reaction with tetrazine is studied. Ternary conjugation was demonstrated by the reaction of a model glyco-peptide binary conjugate with a fluorescent tagged olefin.

1 aRao, Boddu, Venkateswa1 aDhokale, Snehal, A.1 aRajamohanan, Pattuparambil, R.1 aHotha, Srinivas uhttps://library.ncl.res.in/content/tetrazine-templated-method-synthesis-ternary-conjugates-001000nas a2200181 4500008004100000245009700041210006900138260000800207300001800215490000700233520033900240100001700579700001400596700002100610700003500631700002200666856013000688 2013 eng d00aTransition-metal-free multicomponent reactions involving arynes, N-heterocycles, and isatins0 aTransitionmetalfree multicomponent reactions involving arynes Nh cAUG a10040–100430 v523 a

Mix and match: With isoquinoline as the nucleophilic trigger, multicomponent reactions afforded spirooxazino isoquinoline derivatives, proceeding through 1,4-dipolar intermediates. The use of pyridine as a nucleophile furnished indolin-2-one derivatives, with the reaction likely proceeding through a pyridylidene intermediate.

1 aBhunia, Anup1 aRoy, Tony1 aPachfule, Pradip1 aRajamohanan, Pattuparambil, R.1 aBiju, Akkattu, T. uhttps://library.ncl.res.in/content/transition-metal-free-multicomponent-reactions-involving-arynes-n-heterocycles-and-isatins02225nas a2200205 4500008004100000022001400041245012900055210006900184260007100253300001200324490000700336520140500343100002701748700002101775700001901796700002601815700003501841700001701876856012601893 2016 eng d a0022-326300aTuning emission responses of a triphenylamine derivative in host-guest complexes and an unusual dynamic inclusion phenomenon0 aTuning emission responses of a triphenylamine derivative in host a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJAN a512-5210 v813 a

A newly synthesized triphenylamine derivative (1Cl(3)) shows significant differences in inclusion complex formation with two different macrocyclic hosts, cucurbit[7]uril (CB[7]) and beta-cyclodextrin (beta-CD). Detailed investigations by NMR spectroscopy reveal that CB[7] forms a 1:3 host-guest complex ([1 center dot 3{CB[7]}]Cl-3) in which three arms of 1Cl(3) are bound to three host molecules. On the other hand, beta-CD forms a dynamic 1:1 inclusion complex ([1 center dot{beta-CD}]Cl-3) by binding to only one of the three arms of 1Cl(3) at a given time. The formation of a 1:1 host-guest complex with beta-CD and 1:3 host-guest complex with CB[7] was also confirmed from the results of the isothermal titration calorimetric studies. Interestingly, 1Cl(3) exhibits a rare dual emission property in solution at room temperature with the lower and higher energy bands arising from a locally excited state and an intramolecular charge-transfer transition, respectively. The difference in inclusion complex formation behavior of 1Cl(3) with the two macrocyclic hosts results in the stabilization of different emission states in the two inclusion complexes. The fundamental difference in the electrostatic surface potentials, cavity polarities, and shapes of the two macrocyclic hosts could account for the formation of the different inclusion complexes with distinct luminescence responses.

1 aGangopadhyay, Monalisa1 aMandal, Amal, K.1 aMaity, Arunava1 aRavindranathan, Sapna1 aRajamohanan, Pattuparambil, R.1 aDas, Amitava uhttps://library.ncl.res.in/content/tuning-emission-responses-triphenylamine-derivative-host-guest-complexes-and-unusual-1