02370nas a2200253   4500008004100000022001400041245019400055210006900249260000800318300001200326490000600338520140500344100002601749700002501775700002201800700002301822700002101845700001801866700002201884700002401906700002801930700002601958856013201984       2021                        eng d  a2047-483000aGreen synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo0 aGreen synthesis of methoxypolyethylene glycolblockpolyllactideco  cFEB  a795-8060 v93 a<p>Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140-160 nm), surface charge (similar to-10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween (R) 80 coated NP-Ir, the Pluronic (R) F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery.</p>
1 aGiram, Prabhanjan, S.1 aWang, Julie, Tzu-Wen1 aWalters, Adam, A.1 aRade, Priyanka, P.1 aAkhtar, Muhammad1 aHan, Shunping1 aFaruqu, Farid, N.1 aAbdel-Bar, Hend, M.1 aGarnaik, Baijayantimala1 aAl-Jamal, Khuloud, T.  uhttps://library.ncl.res.in/content/green-synthesis-methoxy-polyethylene-glycol-block-polyl-lactide-co-glycolide-copolymer-using02436nas a2200241   4500008004100000022001400041245016800055210006900223260000800292300001200300490000700312520154000319653001901859653002201878653001901900653001701919653001401936100003401950700002401984700002802008700002702036856013102063       2026                        eng d  a1060-132500aGreen synthesis of PLGA and fabrication of topotecan and thymoquinone dual anticancer drug loaded PLGA nanoparticles: a controlled release study for cancer therapy0 aGreen synthesis of PLGA and fabrication of topotecan and thymoqu  cMAR  a232-2460 v633 a<p>
	Cancer therapy is often hindered by poor solubility, low bioavailability, drug resistance, and tumor microenvironmental barriers associated with conventional chemotherapeutics. Polymeric nano-drug delivery systems offer a promising strategy to overcome these limitations, particularly for synergistic multi-drug delivery. In this study, a biodegradable and biocompatible PLGA copolymer (70:30, M-w approximate to 14,500) was synthesized by ring-opening polymerization using zinc proline complex as an initiator through a green route. The copolymer's potential for delivering topotecan (TPT), a water-soluble chemotherapeutic, thymoquinone (TQ), a poorly water-soluble chemotherapeutic, and their combination (TPT+TQ) for cancer treatment was investigated. These nanoparticles demonstrateda consistent particle size &lt; 200 nm high encapsulation efficiency along with desirable controlled-release attributes. Moreover, they exhibited specific release characteristics and cytotoxic effects against HeLa cells, achieving an IC50 value of 20.88 M for the combination therapy (TPT+TQ). Additionally, cytocompatibility testing on L929 fibroblasts confirmed over 98% cell viability for blank PLGA nanoparticles. Additionally, confocal imaging studies confirmed efficient cellular uptake and nuclear localization of the nanoparticles. Overall, the PLGA based dual drug loaded nanoparticles presents a promising approach for targeted, synergistic co-delivery, potentially improving efficacy and reducing toxicity in cancer therapy.</p>
10aBiodegradation10adual drug-loading10aPLGA copolymer10athymoquinone10aTopotecan1 aCheekuramelli, Naga, Srilatha1 aMuhammed, Hasin, N.1 aGarnaik, Baijayantimala1 aNair, Kiran, Sukumaran  uhttps://library.ncl.res.in/content/green-synthesis-plga-and-fabrication-topotecan-and-thymoquinone-dual-anticancer-drug-loaded