00630nas a2200157   4500008004100000245010000041210006900141260000800210300001400218490000600232100002400238700002200262700002300284700002800307856013700335       2012                        eng d00aSynthesis of linear polylactic acid –based urethanes using tin modified closite -30b catalyst0 aSynthesis of linear polylactic acid based urethanes using tin mo  cJAN  a161 - 1710 v31 aSelukar, Balaji, S.1 aParwe, Sharad, P.1 aMohite, Kavita, K.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/synthesis-linear-polylactic-acid-%E2%80%93based-urethanes-using-tin-modified-closite-30b-catalyst02722nas a2200301   4500008004100000022001400041245012500055210006900180260008400249300001400333490000600347520162800353653002701981653004202008653001102050653001702061653002002078653000802098653002402106653001902130100002202149700002502171700002302196700002402219700002102243700002802264856012802292       2014                        eng d  a1178-201300aSynthesis of ciprofloxacin-conjugated poly(L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation0 aSynthesis of ciprofloxacinconjugated polyLlactic acid polymer fo  aPO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALANDbDOVE MEDICAL PRESS LTDcMAR  a1463-14770 v93 a<p>Ciprofloxacin was conjugated with polylactide (PLA) via the secondary amine group of the piperazine ring using PLA and 7-(4-(2-Chloroacetyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. Zinc prolinate, a biocompatible catalyst was synthesized, characterized, and used in ring opening polymerization of L-lactide. Five different kinds of OH-terminated poly(L-lactide) (two-, three-, four-, six-arm, star-shaped) homopolymers were synthesized by ring opening polymerization of L-lactide in the presence of dodecanol, glycerol, pentaerythritol, dipentaerythritol as initiator and zinc prolinate as a catalyst. The structures of the polymers and conjugates were thoroughly characterized by means of gel permeation chromatography, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and nuclear magnetic resonance spectroscopy. PLA (molecular weight = 100,000) and ciprofloxacin conjugated PLA were used for fabrication of nonwoven nanofiber mat (diameter ranges; 150-400 nm) having pore size (62-102 nm) using electrospinning. The microbiological assessment shows that the release of ciprofloxacin possesses antimicrobial activity. The drug-release behavior of the mat was studied to reveal potential application as a drug delivery system. The result shows that the ciprofloxacin release rates of the PLA conjugate nonwoven nanofiber mat could be controlled by the drug loading content and the release medium. The development of a biodegradable ciprofloxacin system, based on nonwoven nanofiber mat, should be of great interest in drug delivery systems.</p>10aantibacterial activity10aciprofloxacin conjugated polylactides10aCP-PLA10adrug release10aelectrospinning10aMDR10anonwoven nanofibers10azinc prolinate1 aParwe, Sharad, P.1 aChaudhari, Priti, N.1 aMohite, Kavita, K.1 aSelukar, Balaji, S.1 aNande, Smita, S.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/synthesis-ciprofloxacin-conjugated-polyl-lactic-acid-polymer-nanofiber-fabrication-and-002147nas a2200217   4500008004100000022001400041245020600055210006900261260000900330300001100339490000800350520128800358653002601646653002501672653001401697653002101711653001601732100002301748700002801771856013001799       2020                        eng d  a0277-538700aKinetic and biocompatibility investigation on the catalytic ring opening polymerization of L-lactide in bulk using cyclic Bu2Sn initiators derived from ethylene glycol, pentaerythritol and cloisite 30B0 aKinetic and biocompatibility investigation on the catalytic ring  cJAN   a1142020 v1753 a<p>In the present work, considering a green approach, PLLA was synthesized by the ring-opening polymerization of L-LA using various cyclic initiators (2,2-dibutyl-2-stanna-1,3-dioxacyclo ethane (1), spirocyclic tin (3) and cloisite modified tin (5)). PLLA was characterized by size exclusion chromatography, differential scanning calorimetry, H-1 and C-13 NMR, XRD and MALDI-TOF. The molecular weight distribution was narrow (&lt;1.5) for both low and high molecular weights (&gt;85,000 g/mol). An X-ray study showed the crystalline nature of PLLA, irrespective of the different types of initiators and polymerization conditions. A kinetic investigation showed that all polymerizations were first order with respect to the monomer and no termination reactions occurred during the polymerization. MALDI-TOF spectra of PLLA chains doped with Na+ and K+ cations show that the PLLA prepared using initiators 1 and 3 have hydroxyl and carboxyl end groups without incorporation of tin. The MALDI-TOF spectrum of PLLA prepared using initiator 5 also enabled the simultaneous detection of the linear and cyclic structure of PLLA without tin. Biocompatible and biodegradable PLLA was obtained, which could be used for biomedical applications. (C) 2019 Elsevier Ltd. All rights reserved.</p>
10aCloisite modified tin10aCyclic tin initiator10aMALDI-TOF10aPoly (L-Lactide)10aSpirocyclic1 aMohite, Kavita, K.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/kinetic-and-biocompatibility-investigation-catalytic-ring-opening-polymerization-l-lactide