00630nas a2200157   4500008004100000245010000041210006900141260000800210300001400218490000600232100002400238700002200262700002300284700002800307856013700335       2012                        eng d00aSynthesis of linear polylactic acid –based urethanes using tin modified closite -30b catalyst0 aSynthesis of linear polylactic acid based urethanes using tin mo  cJAN  a161 - 1710 v31 aSelukar, Balaji, S.1 aParwe, Sharad, P.1 aMohite, Kavita, K.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/synthesis-linear-polylactic-acid-%E2%80%93based-urethanes-using-tin-modified-closite-30b-catalyst02722nas a2200301   4500008004100000022001400041245012500055210006900180260008400249300001400333490000600347520162800353653002701981653004202008653001102050653001702061653002002078653000802098653002402106653001902130100002202149700002502171700002302196700002402219700002102243700002802264856012802292       2014                        eng d  a1178-201300aSynthesis of ciprofloxacin-conjugated poly(L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation0 aSynthesis of ciprofloxacinconjugated polyLlactic acid polymer fo  aPO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALANDbDOVE MEDICAL PRESS LTDcMAR  a1463-14770 v93 a<p>Ciprofloxacin was conjugated with polylactide (PLA) via the secondary amine group of the piperazine ring using PLA and 7-(4-(2-Chloroacetyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. Zinc prolinate, a biocompatible catalyst was synthesized, characterized, and used in ring opening polymerization of L-lactide. Five different kinds of OH-terminated poly(L-lactide) (two-, three-, four-, six-arm, star-shaped) homopolymers were synthesized by ring opening polymerization of L-lactide in the presence of dodecanol, glycerol, pentaerythritol, dipentaerythritol as initiator and zinc prolinate as a catalyst. The structures of the polymers and conjugates were thoroughly characterized by means of gel permeation chromatography, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and nuclear magnetic resonance spectroscopy. PLA (molecular weight = 100,000) and ciprofloxacin conjugated PLA were used for fabrication of nonwoven nanofiber mat (diameter ranges; 150-400 nm) having pore size (62-102 nm) using electrospinning. The microbiological assessment shows that the release of ciprofloxacin possesses antimicrobial activity. The drug-release behavior of the mat was studied to reveal potential application as a drug delivery system. The result shows that the ciprofloxacin release rates of the PLA conjugate nonwoven nanofiber mat could be controlled by the drug loading content and the release medium. The development of a biodegradable ciprofloxacin system, based on nonwoven nanofiber mat, should be of great interest in drug delivery systems.</p>10aantibacterial activity10aciprofloxacin conjugated polylactides10aCP-PLA10adrug release10aelectrospinning10aMDR10anonwoven nanofibers10azinc prolinate1 aParwe, Sharad, P.1 aChaudhari, Priti, N.1 aMohite, Kavita, K.1 aSelukar, Balaji, S.1 aNande, Smita, S.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/synthesis-ciprofloxacin-conjugated-polyl-lactic-acid-polymer-nanofiber-fabrication-and-002092nas a2200181   4500008004100000245013800041210006900179260000800248300001200256490000800268520138400276100002201660700002501682700002001707700002501727700002801752856013001780       2017                        eng d00aInvestigation of the biocompatibility and cytotoxicity associated with ROP initiator and its role in bulk polymerization of L-lactide0 aInvestigation of the biocompatibility and cytotoxicity associate  cFEB  a244-2510 v1113 aPoly (L-lactide) (PLLA) is one of the most attractive polymers for use in biomedical applications. In such applications it is necessary to reduce the use of toxic chemicals and catalysts used in PLLA synthesis, to minimize any adverse effects. In view of this, we have performed ring opening polymerization (ROP) of Llactide (LA) using biocompatible initiator, namely, Zinc L-Proline (ZnP) in bulk. High molecular weight PLLA (Mw up to 1.45 x 10(5) Da) was obtained using the ZnP complex. The ZnP complex is safe, easy to prepare, store and handle. H-1 and C-13 NMR spectra of PLLA were used to determine the extent of monomer conversion and stereo sequence respectively. Differential Scanning Calorimetry (DSC) and Size Exclusion Chromatography (SEC) were used to determine thermal properties, Mn, Mw and polydispersity index respectively. The mechanism of ROP of LA in the presence of ZnP was studied using Density Functional Theory (DFf) which was in good agreement with results from H-1 NMR and Matrix-Assisted Laser Desorption/Ionization Spectrometry (MALDI-TOF). Biocompatibility/non toxicity of PLLA prepared using ZnP was studied in-vitro using MTT assay by examining the proliferation rate of mouse myoblast C2C12 cell line. Escherichia coli and Staphylococcus aureus were used for the study of antibacterial activity of PLLA. (C) 2017 Elsevier Ltd. All rights reserved.1 aParwe, Sharad, P.1 aWarkad, Shrikant, D.1 aMane, Manoj, V.1 aShedage, Pranita, S.1 aGarnaik, Baijayantimala  uhttps://library.ncl.res.in/content/investigation-biocompatibility-and-cytotoxicity-associated-rop-initiator-and-its-role-bulk