01186nas a2200193   4500008004100000245012700041210006900168260000800237300001400245490000800259520048300267100001800750700001800768700001700786700002100803700002300824700001700847856012800864       2011                        eng d00aDiamine derivative of a ruthenium(II)-polypyridyl complex for chemodosimetric detection of nitrite ion in aqueous solution0 aDiamine derivative of a rutheniumIIpolypyridyl complex for chemo  cFEB  a115–1190 v3723 a<p>Nitrite is quite an abundant anion in the environment. It, however, becomes toxic to human life, as well as aquatic animals when present above the permissible concentration level. We have reported here a Ru(II)-polypyridyl-based complex (1) for chemodosimetric detection of nitrite ion in aqueous solution. Formation of the new triazole based complex, generated by reaction of 1 and N2O3, is ascertained by comparing its properties with a presynthesised triazole complex.</p>1 aGhosh, Amrita1 aDas, Priyadip1 aSaha, Sukdeb1 aBanerjee, Tanmay1 aBhatt, Harshad, B.1 aDas, Amitava  uhttps://library.ncl.res.in/content/diamine-derivative-rutheniumii-polypyridyl-complex-chemodosimetric-detection-nitrite-ion02257nas a2200205   4500008004100000022001400041245020800055210006900263260011000332300001400442490000700456520133800463100001801801700002401819700002301843700001801866700002101884700001701905856012901922       2013                        eng d  a1477-052000aDesigning a thiol specific fluorescent probe for possible use as a reagent for intracellular detection and estimation in blood serum: kinetic analysis to probe the role of intramolecular hydrogen bonding0 aDesigning a thiol specific fluorescent probe for possible use as  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a6604-66140 v113 a<p>A new and simple chemodosimetric probe L-1 is utilized for the selective detection of biothiols in the presence of other relevant amino acids under physiological conditions (pH = 7.4). This eventually led to a turn-off luminescence response due to an effective photoinduced electron transfer based signaling mechanism. A comparison of the results of the fluorescence kinetic analysis and H-1 NMR studies of the reaction between thiol and L-1 or the analogous compound L-2 revealed the role of intramolecular hydrogen bonding in activating the imine functionality towards nucleophilic addition. Such an example is not common in contemporary literature. Conventional MTT assay studies revealed that this probe (L-1) has low cytotoxicity. Results of the cell imaging studies revealed that this probe was cell membrane permeable and could detect the intracellular distribution of biothiols within living HeLa cells. Furthermore, our studies with human blood plasma demonstrated the possibility of using this reagent for the quantitative optical detection of total biothiols in biological fluid. Such an example for the detection of biothiols in real biological samples is rare in the contemporary literature. These results clearly demonstrate the possibility of using this reagent in medicinal biology and diagnostic applications.</p>1 aDas, Priyadip1 aMandal, Amal, Kumar1 aReddy, Upendar, G.1 aBaidya, Mithu1 aGhosh, Sudip, K.1 aDas, Amitava  uhttps://library.ncl.res.in/content/designing-thiol-specific-fluorescent-probe-possible-use-reagent-intracellular-detection-0