01109nas a2200217   4500008004100000022001400041245008400055210006900139260010600208300001400314490000700328520031200335653001100647653001900658653001500677653001000692100003200702700002600734700002200760856010900782       2008                        eng d  a0040-403900aNaIO4-KI-NaN3 as a new reagent system for C-H functionalization in hydrocarbons0 aNaIO4KINaN3 as a new reagent system for CH functionalization in   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6401-64030 v493 a<p>The NaIO4-KI-NaN3 combination has been found to be an efficient, reliable, and inexpensive reagent system for mono- and 1,2-difunctionalization of hydrocarbons via C-H bond activation to afford vicinal azido- and acetoxy iodinations of cyclic hydrocarbons. (C) 2008 Elsevier Ltd. All rights reserved.</p>10aazides10aC-H activation10aIodination10aNaIO41 aChouthaiwale, Pandurang, V.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4-ki-nan3-new-reagent-system-c-h-functionalization-hydrocarbons-001096nas a2200181   4500008004100000022001400041245015800055210006900213260010600282300001400388490000700402520027900409100001700688700003200705700002600737700002200763856012900785       2009                        eng d  a0957-416600aConcise enantioselective synthesis of (+)-decarestrictine L via proline-catalyzed sequential alpha-aminooxylation and Horner-Wadsworth-Emmons olefination0 aConcise enantioselective synthesis of decarestrictine L via prol  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a2173-21770 v203 a<p>A short enantioselective synthesis of (+)-decarestrictine L, a cholesterol biosynthesis inhibitor metabolite, is described using a D-proline catalyzed sequential alpha-aminooxylation and a Horner-Wadsworth-Emmons olefination. (C) 2009 Elsevier Lid All rights reserved</p>1 aRawat, Varun1 aChouthaiwale, Pandurang, V.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-decarestrictine-l-proline-catalyzed-sequential-alpha-001191nas a2200241   4500008004100000022001400041245012000055210006900175260010300244300001400347490000700361520029300368653001600661653001300677653001700690653001600707653001100723653001500734100002200749700003200771700002200803856012400825       2009                        eng d  a0376-469900aCu(OTf)(2)-catalyzed alpha-halogenation of ketones with 1,3-dichloro-5,5 `-dimethylhydantoin and N-bromosuccinimide0 aCuOTf2catalyzed alphahalogenation of ketones with 13dichloro55 d  aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScOCT  a1424-14300 v483 a<p>Copper(II) triflate catalyses efficiently the alpha-halogentation of aryl or alkyl ketones with 1,3-dichloro-5,5'-dimethyl-hydantoin and N-bromosaccinimde to give the corresponding alpha,alpha-dichloroketones and alpha-bromoketones in high yield with excellent product selectivity.</p>10aBromination10aCatalyst10achlorination10acopper (II)10aKetone10aLewis acid1 aJagdale, Arun, R.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-catalyzed-alpha-halogenation-ketones-13-dichloro-55-dimethylhydantoin-and-n-001080nas a2200217   4500008004100000022001400041245005900055210005500114260011700169300001000286520031600296653002000612653002400632653001500656653001600671653001200687100003200699700002400731700002200755856008500777       2009                        eng d  a1424-637600aFormal synthesis of (-) anisomycin via organocatalysis0 aFormal synthesis of anisomycin via organocatalysis  aC/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USAbARKAT USA INCcJAN  a88-943 a<p>An efficient formal synthesis of (-) anisomycin (1), a potent antibiotic agent, has been achieved in good yields and excellent diastereoselectivity. The key steps are proline-catalyzed sequential alpha-amination or alpha-aminoxylation of aldehyde 2 followed by tandem Horner-Wadsworth-Emmons olefination.</p>10aalpha-Amination10aalpha-aminoxylation10aanisomycin10aolefination10aProline1 aChouthaiwale, Pandurang, V.1 aKotkar, Shriram, P.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/formal-synthesis-anisomycin-organocatalysis-001248nas a2200193   4500008004100000022001400041245016300055210006900218260011000287300001400397490000700411520039500418100002000813700003200833700002600865700002200891700002200913856011900935       2010                        eng d  a1359-734500aCo(III)(salen)-catalyzed HKR of two stereocentered alkoxy- and azido epoxides: a concise enantioselective synthesis of (S,S)-reboxetine and (+)-epi-cytoxazone0 aCoIIIsalencatalyzed HKR of two stereocentered alkoxy and azido e  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN  a5012-50140 v463 a<p>The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S, S)-reboxetine and (+)-epi-cytoxazone.</p>1 aReddy, Santhosh1 aChouthaiwale, Pandurang, V.1 aSuryavanshi, Gurunath1 aChavan, Vilas, B.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/coiiisalen-catalyzed-hkr-two-stereocentered-alkoxy-and-azido-epoxides-concise-001569nas a2200253   4500008004100000022001400041245019000055210006900245260010600314300001400420490000700434520053900441653002000980653002501000653002401025653001801049653001201067100001701079700003201096700002201128700002601150700002201176856011701198       2010                        eng d  a0040-403900aFacile enantioselective synthesis of (S)-N-(5-chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol via proline-catalyzed asymmetric alpha-aminooxylation and alpha-amination of aldehyde0 aFacile enantioselective synthesis of SN5chlorothiophene2sulfonyl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a6565-65670 v513 a<p>A high-yielding enantioselective synthesis of the bioactive (S)-N-(5-chlorothiophene-2-sulfonyl)beta,beta-diethylalaninol (1), a Notch-1-sparing gamma-secretase inhibitor metabolite (with EC50 = 28 nM) effective in reduction of All production in vivo, has been realized starting from readily available 3-pentanone. The key steps of the synthesis are proline-catalyzed alpha-aminooxylation and alpha-amination of aldehyde: the latter contributing an overall yield of 45.2% and 98% ee. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aalpha-Amination10aalpha-Aminooxylation10aAlzheimer's disease10aAmino alcohol10aProline1 aRawat, Varun1 aChouthaiwale, Pandurang, V.1 aChavan, Vilas, B.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/facile-enantioselective-synthesis-s-n-5-chlorothiophene-2-sulfonyl-betabeta-001343nas a2200253   4500008004100000022001400041245006800055210006500123260010600188300001400294490000700308520045200315653001800767653001700785653002000802653001100822653002500833100002600858700003200884700002400916700002600940700002200966856010100988       2010                        eng d  a0040-403900aNaIO4/LiBr-mediated aziridination of olefins using chloramine-T0 aNaIO4LiBrmediated aziridination of olefins using chloramineT  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC  a6460-64620 v513 a<p>A new milder protocol for aziridination of a variety of olefins has been described. The process employs catalytic amount of sodium metaperiodate (NaIO4) as an oxidant and LiBr and chloramine-T as the bromine and nitrogen sources, respectively. Interestingly, the formation of aziridine products in all the cases studied takes place presumably through a process of 1,2-aminobromination of alkenes. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aAziridination10aChloramine-T10aLithium bromide10aOlefin10aSodium metaperiodate1 aKarabal, Pratibha, U.1 aChouthaiwale, Pandurang, V.1 aShaikh, Tanveer, M.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4libr-mediated-aziridination-olefins-using-chloramine-t-001222nas a2200229   4500008004100000022001400041245014600055210006900201260007500270300001400345520031500359653001200674653001100686653002000697653002000717653001900737100003200756700002600788700002600814700002200840856013000862       2010                        eng d  a0039-788100aRegiospecific azidoiodination of alkenes with sodium periodate, potassium iodide, and sodium azide: a high-yield synthesis of beta-iodoazides0 aRegiospecific azidoiodination of alkenes with sodium periodate p  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcNOV  a3879-38823 a<p>The combination of sodium periodate, potassium iodide, and sodium azide has been found to be an efficient, simple, and inexpensive reagent system for azidoiodination of alkenes. The regiospecific 1,2-azidoiodination proceeds in an anti-Markovnikov fashion to produce beta-iodoazides in excellent yields.</p>10aalkenes10aazides10aazidoiodination10abeta-iodoazides10aregio-specific1 aChouthaiwale, Pandurang, V.1 aKarabal, Pratibha, U.1 aSuryavanshi, Gurunath1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/regiospecific-azidoiodination-alkenes-sodium-periodate-potassium-iodide-and-sodium-azide-001271nas a2200241   4500008004100000022001400041245009400055210006900149260010600218300001400324490000700338520036200345653001200707653001700719653002100736653002100757653002100778100002500799700002600824700003200850700002200882856012500904       2012                        eng d  a0040-403900aNaIO4-NaN3-mediated diazidation of styrenes, alkenes, benzylic alcohols, and aryl ketones0 aNaIO4NaN3mediated diazidation of styrenes alkenes benzylic alcoh  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4195-41980 v533 a<p>Sodium periodate and sodium azide combination has been found to be an excellent reagent system suitable for the direct diazidation of styrenes, alkenes, benzylic alcohols, and aryl ketones to produce the corresponding vicinal and geminal diazides respectively in high yields under mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.</p>10aalkenes10aAryl ketones10aGeminal diazides10aSodium periodate10aVicinal diazides1 aKamble, Dayanand, A.1 aKarabal, Pratibha, U.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/naio4-nan3-mediated-diazidation-styrenes-alkenes-benzylic-alcohols-and-aryl-ketones-001276nas a2200229   4500008004100000022001400041245007300055210006900128260010600197300001200303490000700315520046700322653001400789653002000803653001200823653001400835653001900849100003200868700001700900700002200917856010700939       2012                        eng d  a0040-403900aPd-catalyzed selective hydrosilylation of aryl ketones and aldehydes0 aPdcatalyzed selective hydrosilylation of aryl ketones and aldehy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a148-1500 v533 a<p>Pd salts in combination with triethylsilane as hydride source and DMF as solvent has been found to be excellent catalytic combination that selectively reduces aryl ketones and aldehydes under mild conditions to afford triethylsilyloxy compounds in excellent yields. Product selectivity to the respective benzyl alcohols can however be achieved when the reaction was performed in DMF/H2O (4:1) as solvent system. (C) 2011 Elsevier Ltd. All rights reserved.</p>10aaldehydes10aHydrosilylation10aKetones10aPalladium10aTriethylsilane1 aChouthaiwale, Pandurang, V.1 aRawat, Varun1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/pd-catalyzed-selective-hydrosilylation-aryl-ketones-and-aldehydes-001366nas a2200241   4500008004100000022001400041245019800055210006900253260007500322300001200397490000700409520039700416653001100813653001700824653001300841653001600854653003000870653002100900100003000921700003200951700002200983856011901005       2014                        eng d  a0936-521400aConcise enantioselective syntheses of (+)-L-733,060 and (2S,3S)-3-hydroxypipecolicw acid by cobalt(III)(salen)-catalyzed two-stereocenter hydrolytic kinetic resolution of racemic azido epoxides0 aConcise enantioselective syntheses of L733060 and 2S3S3hydroxypi  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJAN  a102-1040 v253 a<p>An efficient synthesis of the 2,3-disubstituted piperidines (+)-L-733,060 and (2S,3S)-3-hydroxypipecolic acid (99% ee) in high optical purity from commercially available starting materials is described. The strategy involves a cobalt-catalyzed hydrolytic kinetic resolution of a racemic azido epoxide with two stereocenters and an intramolecular reductive cyclization as key reactions.</p>10aazides10acyclizations10aepoxides10apiperidines10astereoselective synthesis10aWittig reactions1 aDevalankar, Dattatray, A.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-syntheses-l-733060-and-2s3s-3-hydroxypipecolicw-acid-0