02381nas a2200289   4500008004100000022001400041245008400055210006900139260000900208300001100217490000800228520148700236653001201723653001701735653002701752653002501779653001201804100001801816700002301834700002801857700002101885700001701906700001801923700001901941700002201960856010901982       2022                        eng d  a0926-669000aCrystalline xylitol production from corncob biomass with oral toxicity analysis0 aCrystalline xylitol production from corncob biomass with oral to  cNOV   a1154070 v1873 a<p>
	Xylitol, a five-carbon sugar alcohol, has a steady global market and finds application as a natural sugar substitute in various food and confectionery products. Biocatalytic xylitol production, although touted as a greener alternative to conventional chemical catalysis, suffers from certain challenges, the primary being high cost of production. This study demonstrates a process for food-grade xylitol production from corncob biomass with energy reduction through two major process modifications. A non-conventional fermentation strategy was adopted whereby adjusting aeration without agitation, xylitol with high yield (0.86 +/- 0.015 g/g), and productivity (0.74 gL(-1)h(-1)) could be produced by a GRAS Pichia caribbica MTCC 5703 strain. Xylitol was recovered from the broth in the form of crystals using a combination of membrane-based filtration and crystallization. The crystals demonstrated similar to 98 % purity when quantified with H-1 NMR. Oral toxicity analysis of the crystals demonstrated no adverse effect in female Winstar rats (at a loading of 2000 mg/kg body weight of animals). Overall process statistics showed that 0.584 kg of food-grade xylitol crystals could be produced from 3.5 kg of corncob biomass. The two-process modifications during fermentation and xylitol recovery enabled an energy saving of similar to 20.842 kW/kg of crystals, providing tremendous advantages for biorefinery-based large-scale xylitol production from corncob biomass.</p>
10aBiomass10aFermentation10aOral toxicity analysis10aWastewater treatment10axylitol1 aAhuja, Vishal1 aDasgupta, Diptarka1 aKshirsagar, Siddheshwar1 aGhosh, Prasenjit1 aMore, Snehal1 aGupta, Piyush1 aBehera, Babita1 aBhaskar, Thallada  uhttps://library.ncl.res.in/content/crystalline-xylitol-production-corncob-biomass-oral-toxicity-analysis01688nas a2200229   4500008004100000022001400041245011100055210006900166260000800235300001100243490000800254520092400262653001501186653002601201653001101227653001201238653001201250100002401262700002301286700001701309856013201326       2023                        eng d  a0926-669000aChallenges and opportunities for production of C5 sugar fatty acid esters (SFAEs) from renewable resources0 aChallenges and opportunities for production of C5 sugar fatty ac  cMAR  a1161700 v1933 a<p>
	Sugar fatty acid esters represent a billion-dollar market with huge global demand. Although glucose and sucrose-based surfactants have prevailed in the chemical industry for decades, C-5-based esters are relatively unknown and have recently started to gain attention owing to their multifunctional properties. These molecules can be derived from cheap and inexpensive biomass/renewable resources and present promising potential with diverse applications as additives in various nutraceutical, pharmaceutical, and cosmeceutical formulations. However, large-scale production of C-5 sugar esters is limited, with one or two commercial plants operating worldwide. This review highlights the major challenges and prospects of biotechnological production of the C-5 sugar esters, considering the possible advancements over existing technology with various aspects of industrial bioprocessing and product recovery.</p>
10aBioprocess10aC-5-fatty acid esters10aLipase10asolvent10axylitol1 aTracy, Preetanshika1 aDasgupta, Diptarka1 aMore, Snehal  uhttps://library.ncl.res.in/content/challenges-and-opportunities-production-c5-sugar-fatty-acid-esters-sfaes-renewable-resources