02344nas a2200289   4500008004100000022001400041245008000055210006900135260000900204300001100213490000800224520144400232653002501676653003301701653001501734653001201749100002301761700002201784700002101806700001901827700002101846700002101867700001701888700002201905700002101927856010601948       2021                        eng d  a0959-652600aEnergy and life cycle impact assessment for xylitol production from corncob0 aEnergy and life cycle impact assessment for xylitol production f  cJAN   a1232170 v2783 a<p>The conversion of biobased feedstocks into energy and value-added chemicals is one main approach to address the current global challenge for waste mitigation through the biorefinery mode. Corncob biomass which is one of the most abundant agricultural residue in India with a high hemicellulose content, can serve as a potential low-cost raw material for food-grade xylitol production. The present study demonstrates a process for xylitol production from corncob biomass with detailed energy and life cycle analysis for viability assessment. The major highlight of the process is the use of microbial fermentation, where biomass-derived D-xylose is converted to xylitol with high selectivity. Overall, 0.502 kg of xylitol crystals could be produced from 3.5 kg of corncob biomass. Simulation analysis revealed that the evaporators are the primary consumers of energy, and the process of heat integration can significantly reduce the energy requirements of the overall process. Environmental impacts of the system evaluated showed emission results of 8.68 kg CO2 equivalent and revealed that marine aquatic and freshwater eco-toxicity are the only possible contributors to the environment. The results suggest that the process would have favourable energy balances, which can be used in pilot plant and heat exchanger network design and operation for xylitol production scale up to 500 L. (C) 2020 Elsevier Ltd. All rights reserved.</p>
10abiomass valorization10aLife cycle impact assessment10asimulation10axylitol1 aDasgupta, Diptarka1 aSidana, Arushdeep1 aGhosh, Prasenjit1 aSharma, Tripti1 aSingh, Jasvinder1 aPrabhune, Asmita1 aMore, Snehal1 aBhaskar, Thallada1 aGhosh, Debashish  uhttps://library.ncl.res.in/content/energy-and-life-cycle-impact-assessment-xylitol-production-corncob02381nas a2200289   4500008004100000022001400041245008400055210006900139260000900208300001100217490000800228520148700236653001201723653001701735653002701752653002501779653001201804100001801816700002301834700002801857700002101885700001701906700001801923700001901941700002201960856010901982       2022                        eng d  a0926-669000aCrystalline xylitol production from corncob biomass with oral toxicity analysis0 aCrystalline xylitol production from corncob biomass with oral to  cNOV   a1154070 v1873 a<p>
	Xylitol, a five-carbon sugar alcohol, has a steady global market and finds application as a natural sugar substitute in various food and confectionery products. Biocatalytic xylitol production, although touted as a greener alternative to conventional chemical catalysis, suffers from certain challenges, the primary being high cost of production. This study demonstrates a process for food-grade xylitol production from corncob biomass with energy reduction through two major process modifications. A non-conventional fermentation strategy was adopted whereby adjusting aeration without agitation, xylitol with high yield (0.86 +/- 0.015 g/g), and productivity (0.74 gL(-1)h(-1)) could be produced by a GRAS Pichia caribbica MTCC 5703 strain. Xylitol was recovered from the broth in the form of crystals using a combination of membrane-based filtration and crystallization. The crystals demonstrated similar to 98 % purity when quantified with H-1 NMR. Oral toxicity analysis of the crystals demonstrated no adverse effect in female Winstar rats (at a loading of 2000 mg/kg body weight of animals). Overall process statistics showed that 0.584 kg of food-grade xylitol crystals could be produced from 3.5 kg of corncob biomass. The two-process modifications during fermentation and xylitol recovery enabled an energy saving of similar to 20.842 kW/kg of crystals, providing tremendous advantages for biorefinery-based large-scale xylitol production from corncob biomass.</p>
10aBiomass10aFermentation10aOral toxicity analysis10aWastewater treatment10axylitol1 aAhuja, Vishal1 aDasgupta, Diptarka1 aKshirsagar, Siddheshwar1 aGhosh, Prasenjit1 aMore, Snehal1 aGupta, Piyush1 aBehera, Babita1 aBhaskar, Thallada  uhttps://library.ncl.res.in/content/crystalline-xylitol-production-corncob-biomass-oral-toxicity-analysis02115nas a2200289   4500008004100000022001400041245010000055210006900155260000800224300001000232490000800242520122000250653001201470653001201482653001901494653001701513653002201530653001201552100002301564700002201587700001801609700001701627700002101644700002201665700001501687856012301702       2022                        eng d  a0960-308500aProcess development for crystalline xylitol production from corncob biomass by Pichia caribbica0 aProcess development for crystalline xylitol production from corn  cMAY  a45-560 v1333 a<p>
	Xylitol, a commodity chemical, is widely used in nutraceutical and pharmaceutical formulations. Microbial xylitol production is a promising alternative to mitigate current industrial practice issues and offers an environment-friendly sustainable conversion route. This study demonstrates a bioprocess for xylitol production from corncob using a mesophilic yeast Pichia caribbica. Corncob was hydrolyzed by dilute acid and steam explosion to recover fermentable xylose and used as the feed for xylitol production. Activated carbon treatment (3% w/v) completely removed the biomass-derived inhibitors furfural and hydroxymethyl furfural from the liquid hydrolysate. The fermenting yeast Pichia caribbica produced 124.1 +/- 0.45 g/L xylitol from the detoxified and concentrated corncob hydrolysate with a high yield of 0.80 +/- 0.02 g/g. The crystallized xylitol with 96.5% purity demonstrated no harmful effects on the cell line used as a control for the in-vitro toxicity studies. This proof of concept can be applied to help scale up for bio-refinery-based large-scale production of xylitol from corncob biomass.(c) 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.</p>
10aBiomass10aCorncob10aDetoxification10aFermentation10aToxicity analysis10axylitol1 aDasgupta, Diptarka1 aSidana, Arushdeep1 aSarkar, Bipul1 aMore, Snehal1 aGhosh, Debashish1 aBhaskar, Thallada1 aRay, Anjan  uhttps://library.ncl.res.in/content/process-development-crystalline-xylitol-production-corncob-biomass-pichia-caribbica01602nas a2200277   4500008004100000022001400041245011400055210006900169260000800238300001100246490000700257520070400264653002300968653001900991653001701010653001701027653001201044100001801056700002801074700002101102700001801123700001601141700001701157700002301174856012701197       2022                        eng d  a2213-292900aProcess development for detoxification of corncob hydrolysate using activated charcoal for xylitol production0 aProcess development for detoxification of corncob hydrolysate us  cFEB  a1070970 v103 aThe work describes process development for detoxification of corncob hydrolysate using activated carbon for microbial xylitol production. Activated carbon was used as an adsorbent to completely remove the major fermentation inhibitors obtained during dilute acid and steam explosion of biomass. A xylitol yield of 0.78 g/g was achieved from the detoxified hydrolysate in a 5 L fermenter by Pichia caribbica. The spent carbon was effectively regenerated and used for three consecutive cycles of operation. The successive regeneration and reuse of carbon could reduce the operational cost by similar to 38% and be used as a reference dataset for process scale-up and cost-effective xylitol production.10aActivated charcoal10aDetoxification10aFermentation10aRegeneration10axylitol1 aAhuja, Vishal1 aKshirsagar, Siddheshwar1 aGhosh, Prasenjit1 aSarkar, Bipul1 aSutar, Ajit1 aMore, Snehal1 aDasgupta, Diptarka  uhttps://library.ncl.res.in/content/process-development-detoxification-corncob-hydrolysate-using-activated-charcoal-xylitol01688nas a2200229   4500008004100000022001400041245011100055210006900166260000800235300001100243490000800254520092400262653001501186653002601201653001101227653001201238653001201250100002401262700002301286700001701309856013201326       2023                        eng d  a0926-669000aChallenges and opportunities for production of C5 sugar fatty acid esters (SFAEs) from renewable resources0 aChallenges and opportunities for production of C5 sugar fatty ac  cMAR  a1161700 v1933 a<p>
	Sugar fatty acid esters represent a billion-dollar market with huge global demand. Although glucose and sucrose-based surfactants have prevailed in the chemical industry for decades, C-5-based esters are relatively unknown and have recently started to gain attention owing to their multifunctional properties. These molecules can be derived from cheap and inexpensive biomass/renewable resources and present promising potential with diverse applications as additives in various nutraceutical, pharmaceutical, and cosmeceutical formulations. However, large-scale production of C-5 sugar esters is limited, with one or two commercial plants operating worldwide. This review highlights the major challenges and prospects of biotechnological production of the C-5 sugar esters, considering the possible advancements over existing technology with various aspects of industrial bioprocessing and product recovery.</p>
10aBioprocess10aC-5-fatty acid esters10aLipase10asolvent10axylitol1 aTracy, Preetanshika1 aDasgupta, Diptarka1 aMore, Snehal  uhttps://library.ncl.res.in/content/challenges-and-opportunities-production-c5-sugar-fatty-acid-esters-sfaes-renewable-resources01751nas a2200265   4500008004100000022001400041245008800055210006900143260000800212300000800220490000700228520093200235653002401167653001201191653001701203653002401220653001201244100002301256700001801279700002001297700001701317700002101334700001701355856011301372       2023                        eng d  a0959-399300aFood-grade xylitol production from corncob biomass with acute oral toxicity studies0 aFoodgrade xylitol production from corncob biomass with acute ora  cAPR  a1020 v393 a<p>
	Xylitol, a sugar substitute, is widely used in various food formulations and finds a steady global market. In this study, xylitol crystals were produced from corncob by fermentation (as an alternative to the chemical catalytic process) by a GRAS yeast Pichia caribbica MTCC 5703 and characterized in detail for their purity and presence of any possible contaminant that may adversely affect mammalian cell growth and proliferation. The acute and chronic oral toxicity trials demonstrated no gross pathological changes with average weekly weight gain in female Wistar rats at high xylitol loading (LD50 &gt; 10,000 mg/kg body weight). The clinical chemistry analysis supported the evidence of no dose-dependent effect by analyzing blood biochemical parameters. The finding suggests the possible application of the crystals (&gt; 98% purity) as a food-grade ingredient for commercial manufacture pending human trials.</p>
10aAcute oral toxicity10aCorncob10aFermentation10aShelf life analysis10axylitol1 aDasgupta, Diptarka1 aAhuja, Vishal1 aSingh, Raghuvir1 aMore, Snehal1 aMudliar, Sandeep1 aKumar, Madan  uhttps://library.ncl.res.in/content/food-grade-xylitol-production-corncob-biomass-acute-oral-toxicity-studies