01892nas a2200229   4500008004100000022001400041245013700055210006900192260009600261300001000357490000800367520100900375653001301384653002601397653001401423653002201437653001501459100001701474700001901491700002001510856013201530       2010                        eng d  a1022-136000aUltrasound-triggered release of ibuprofen from a chitosan-mesoporous silica composite - a novel approach for controlled drug release0 aUltrasoundtriggered release of ibuprofen from a chitosanmesoporo  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbInt Union Pure & Appl Chem; German Res FdncJAN  a80-880 v2873 a<p>In this work, an attempt was made to synthesize a novel Chitosan-Mesoporous silica (CS-MS) hybrid composite to design a drug delivery system based on ultrasound triggered stimuli-responsive smart release. The in-vitro drug release properties of both the Mesoporous Silica (MS) and Chitosan (CS) hybrids were investigated. Ibuprofen (Ibu) was used as a model drug. The results from powder X-Ray diffraction (XRD) patterns, and BET N(2) adsorption isotherms exhibited that MS can accommodate drug molecules into the lumen of the channels and pores. Drug release, stimulated by temperature and pH of the release media was also investigated. We studied the Ultrasound (US) triggered release of Ibu in a simulated body fluid (pH 7.4). The results exhibited that US can be used as a non-invasive technique for drug release from polymeric materials. The enhancing effect of ultrasound on drug release is due to the Cavitation effect, without causing any significant destruction on the polymer morphology.</p>10aChitosan10adrug delivery systems10aibuprofen10aMesoporous silica10aUltrasound1 aDepan, Dilip1 aSaikia, Lakshi1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/ultrasound-triggered-release-ibuprofen-chitosan-mesoporous-silica-composite-novel-approach-0