02006nas a2200217   4500008004100000022001400041245011000055210006900165260007300234300001200307490000700319520118700326653001301513653002501526653002701551653002001578653001801598100002101616700002001637856013101657       2012                        eng d  a0141-813000aGlycolic acid-g-chitosan-gold nanoflower nanocomposite scaffolds for drug delivery and tissue engineering0 aGlycolic acidgchitosangold nanoflower nanocomposite scaffolds fo  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR  a878-8830 v503 a<p>This paper reports a simple novel method for the synthesis of flower like gold nanoparticle (three dimensional branched nanoparticle) with &gt;30 tips, under controlled temperature condition. Formation of flower like Au nanoparticle was confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and gold nanoflower (AuNF) in controlled drug delivery and tissue engineering applications. The drug loaded novel nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Grafting of glycolic acid to the chitosan and incorporation of drug were evaluated by Fourier transform infrared spectroscopy (FTIR). The nanohybrid scaffolds were found to be stable towards the pH of the medium. The cell viability study shows that prepared nanohybrid scaffolds are biocompatible. Gold nanoflowers were found to control the drug release rate in the buffer solution (pH 7.4). Therefore, for the glycolic acid grafted chitosan based system, gold nanoflowers are the viable additive for drug delivery. (C) 2011 Elsevier B.V. All rights reserved.</p>10aChitosan10aDrug delivery system10aGlycolic acid grafting10aGold nanoflower10aNanocomposite1 aKumari, Sangeeta1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/glycolic-acid-g-chitosan-gold-nanoflower-nanocomposite-scaffolds-drug-delivery-and-tissue-002030nas a2200217   4500008004100000022001400041245011300055210006900168260007300237300001000310490000700320520120200327653001901529653001301548653001801561653002701579653003301606100002101639700002001660856013201680       2012                        eng d  a0141-813000aGlycolic acid-g-chitosan-Pt-Fe3O4 nanoparticles nanohybrid scaffold for tissue engineering and drug delivery0 aGlycolic acidgchitosanPtFe3O4 nanoparticles nanohybrid scaffold   aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUL  a76-820 v513 a<p>This work presents the potential use of novel nanohybrid based on chitosan-g-glycolic acid and Pt-Fe3O4 composite nanoparticles in drug delivery and tissue engineering applications. The Pt-Fe3O4 hybrid nanoparticles are prepared by thermal decomposition of H2PtCl6 center dot 6H(2)O at high temperature. The prepared nanoparticles were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and physical property measurement system (PPMS). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and Pt-Fe3O4 hybrid nanoparticles in controlled drug delivery applications. The drug loaded nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Drug loading and grafting of chitosan was characterized by Fourier transform infrared spectroscopy (FTIR). The cell proliferation also shows that the prepared nanohybrids are biocompatible. The nanohybrid was found to be stable regardless of pH of the medium. Therefore, Pt-Fe3O4 hybrid nanoparticles are viable additive for sustained drug delivery and it could be applied in the field of biomedical. (c) 2012 Elsevier B.V. All rights reserved.</p>10aCell viability10aChitosan10adrug delivery10aGlycolic acid grafting10aPt-Fe3O4 hybrid nanoparticle1 aKumari, Sangeeta1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/glycolic-acid-g-chitosan-pt-fe3o4-nanoparticles-nanohybrid-scaffold-tissue-engineering-and-0