02006nas a2200217   4500008004100000022001400041245011000055210006900165260007300234300001200307490000700319520118700326653001301513653002501526653002701551653002001578653001801598100002101616700002001637856013101657       2012                        eng d  a0141-813000aGlycolic acid-g-chitosan-gold nanoflower nanocomposite scaffolds for drug delivery and tissue engineering0 aGlycolic acidgchitosangold nanoflower nanocomposite scaffolds fo  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR  a878-8830 v503 a<p>This paper reports a simple novel method for the synthesis of flower like gold nanoparticle (three dimensional branched nanoparticle) with &gt;30 tips, under controlled temperature condition. Formation of flower like Au nanoparticle was confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and gold nanoflower (AuNF) in controlled drug delivery and tissue engineering applications. The drug loaded novel nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Grafting of glycolic acid to the chitosan and incorporation of drug were evaluated by Fourier transform infrared spectroscopy (FTIR). The nanohybrid scaffolds were found to be stable towards the pH of the medium. The cell viability study shows that prepared nanohybrid scaffolds are biocompatible. Gold nanoflowers were found to control the drug release rate in the buffer solution (pH 7.4). Therefore, for the glycolic acid grafted chitosan based system, gold nanoflowers are the viable additive for drug delivery. (C) 2011 Elsevier B.V. All rights reserved.</p>10aChitosan10aDrug delivery system10aGlycolic acid grafting10aGold nanoflower10aNanocomposite1 aKumari, Sangeeta1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/glycolic-acid-g-chitosan-gold-nanoflower-nanocomposite-scaffolds-drug-delivery-and-tissue-002162nas a2200205   4500008004100000022001400041245011500055210006900170260007300239300001200312490000700324520132300331653003401654653003601688653002501724653004101749100002101790700002001811856012501831       2013                        eng d  a0141-813000aGlycolic acid functionalized chitosan-Au-Fe3O4 hybrid nanoparticle based nanohybrid scaffold for drug delivery0 aGlycolic acid functionalized chitosanAuFe3O4 hybrid nanoparticle  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAR  a244-2490 v543 a<p>The research on biomedical applications of nanoparticles has seen an upsurge in recent years due to their unique capabilities in treatment of ailments. The present paper reports the synthesis of Au-Fe3O4 hybrid nanoparticles. The formation of these nanoparticles was confirmed by transmission electron microscopy (TEM) and physical property measurement system (PPMS). Next step of this paper reveals potential use of novel hybrid of chitosan-g-glycolic acid and Au-Fe3O4 hybrid nanoparticles in controlled drug delivery and tissue engineering applications. Grafting of glycolic acid and drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of pH of the medium and play a key role in cell adhesion, proliferation and migration. Au-Fe3O4 hybrid nanoparticles reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Au-Fe3O4 hybrid nanoparticles are viable additive for formulating sustained drug delivery systems based on glycolic acid grafted chitosan. The cell proliferation profile also shows that prepared nanohybrid is biocompatible providing suitable substrates for tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.</p>10aAu-Fe3O4 hybrid nanoparticles10aChitosan Glycolic acid grafting10aDrug delivery system10aPhysical property measurement system1 aKumari, Sangeeta1 aSingh, Raj, Pal  uhttps://library.ncl.res.in/content/glycolic-acid-functionalized-chitosan-au-fe3o4-hybrid-nanoparticle-based-nanohybrid-0