01826nas a2200229   4500008004100000022001400041245016600055210006900221260008600290300001200376490000600388520089900394653001901293653002001312653002101332653001601353653003701369100002201406700002001428700001701448856013101465       2014                        eng d  a2190-428600aExtracellular biosynthesis of gadolinium oxide (Gd2O3) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol0 aExtracellular biosynthesis of gadolinium oxide Gd2O3 nanoparticl  aTRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANYbBEILSTEIN-INSTITUTcMAR  a249-2570 v53 a<p>As a part of our programme to develop nanobioconjugates for the treatment of cancer, we first synthesized extracellular, protein-capped, highly stable and well-dispersed gadolinium oxide (Gd2O3) nanoparticles by using thermophilic fungus Humicola sp. The biodistribution of the nanoparticles in rats was checked by radiolabelling with Tc-99m. Finally, these nanoparticles were bioconjugated with the chemically modified anticancer drug taxol with the aim of characterizing the role of this bioconjugate in the treatment of cancer. The biosynthesized Gd2O3 nanoparticles were characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoemission spectroscopy (XPS). The Gd2O3-taxol bioconjugate was confirmed by UV-vis spectroscopy and fluorescence microscopy and was purified by using high performance liquid chromatography (HPLC).</p>10abioconjugation10abiodistribution10agadolinium oxide10ahumicola sp10atransmission electron microscopy1 aKhan, Shadab, Ali1 aGambhir, Sanjay1 aAhmad, Absar  uhttps://library.ncl.res.in/content/extracellular-biosynthesis-gadolinium-oxide-gd2o3-nanoparticles-their-biodistribution-and-0