01103nas a2200229   4500008004100000022001400041245007400055210006900129260007500198300001400273490000700287520029900294653001100593653002400604653001500628653003000643100002200673700002200695700002500717700002700742856010400769       2014                        eng d  a0039-788100aNew enantioselective synthesis of the anti-parkinson agent safinamide0 aNew enantioselective synthesis of the antiparkinson agent safina  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJUL  a1751-17560 v463 a<p>An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues</p>10aAmides10amedicinal chemistry10asafinamide10astereoselective synthesis1 aReddi, Anjaneyulu1 aMujahid, Mohammad1 aSasikumar, Murugesan1 aMuthukrishnan, Murugan  uhttps://library.ncl.res.in/content/new-enantioselective-synthesis-anti-parkinson-agent-safinamide-001229nas a2200193   4500008004100000245010900041210006900150260000800219300001200227490000700239520052000246100002200766700002300788700002100811700002500832700002600857700002700883856012500910       2017                        eng d00aNew and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil0 aNew and efficient enantioselective synthesis of both enantiomers  cJAN  a824-8290 v413 aA concise and efficient enantioselective synthesis of both enantiomers of bepridil, a calcium channel blocker, is reported. Jacobsen's hydrolytic kinetic resolution method was utilized to resolve racemic 2-(isobutoxymethyl) oxirane. The incorporation of the succinimide moiety by the Mitsunobu reaction, which was investigated in detail, occurred without any loss of enantioselectivity. Using this strategy, both enantiomers of the target molecule were obtained in good yield and with high enantiopurity (ee > 99%).1 aMujahid, Mohammad1 aSubramanian, Jambu1 aNalla, Viswanadh1 aSasikumar, Murugesan1 aKunte, Sunita, Sharad1 aMuthukrishnan, Murugan  uhttps://library.ncl.res.in/content/new-and-efficient-enantioselective-synthesis-both-enantiomers-calcium-channel-blocker