01340nas a2200253 4500008004100000022001400041245013000055210006900185260007700254300001400331520038900345653001700734653001300751653002600764653001400790653002200804100002500826700001700851700002400868700002100892700002400913700002100937856012800958 2014 eng d a1434-193X00aGeneral approach to N-heterocyclic carbenes with a fused tetracyclic core: ligands for suzuki-miyaura cross-coupling reaction0 aGeneral approach to Nheterocyclic carbenes with a fused tetracyc aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJUL a4482-44863 a

The synthesis of an N-heterocyclic carbene (NHC) based on a tetracyclic scaffold by using simple, general, and scalable chemistry is disclosed. The developed route is suitable for introducing multiple substitutions on the tetracyclic scaffold. The utility of the present NHC as a ligand in the Suzuki-Miyaura cross-coupling reaction is demonstrated with a low catalyst loading.

10aC-C coupling10acarbenes10aHomogeneous catalysis10aN ligands10asynthetic methods1 aSutar, Revannath, L.1 aKumar, Vinod1 aShingare, Rahul, D.1 aThorat, Shridhar1 aGonnade, Rajesh, G.1 aReddy, Srinivasa uhttps://library.ncl.res.in/content/general-approach-n-heterocyclic-carbenes-fused-tetracyclic-core-ligands-suzuki-miyaura-001454nas a2200241 4500008004100000245012100041210006900162260000800231300001200239490000800251520062500259100001800884700002400902700001700926700001900943700001500962700002700977700002401004700002001028700002401048700002101072856011901093 2016 eng d00aRepurposing of a drug scaffold: identification of novel sila analogues of rimonabant as potent antitubercular agents0 aRepurposing of a drug scaffold identification of novel sila anal cOCT a723-7300 v1223 a

The structural similarity between an MmpL3 inhibitor BM212, and a cannabinoid receptor modulator rimonabant, prompted us to investigate the anti-tubercular activity of rimonabant and its analogues. Further optimization, particularly through incorporation of silicon into the scaffold, resulted in new compounds with significant improvement in anti-tubercular activity against Mycobacterium tuberculosis (H37Rv). The sila analogue 18a was found to be the most potent antimycobacterial compound (MIC, 31 ng/mL) from this series with an excellent selectivity index. (C) 2016 Elsevier Masson SAS. All rights reserved.

1 aRamesh, Remya1 aShingare, Rahul, D.1 aKumar, Vinod1 aAnand, Amitesh1 aSwetha, B.1 aVeeraraghavan, Sridhar1 aViswanadha, Srikant1 aUmmanni, Ramesh1 aGokhale, Rajesh, S.1 aReddy, Srinivasa uhttps://library.ncl.res.in/content/repurposing-drug-scaffold-identification-novel-sila-analogues-rimonabant-potent02718nas a2200157 4500008004100000245015500041210006900196260000800265300001600273490000600289520208000295100002102375700001702396700002302413856012402436 2025 eng d00aTechno-economic analysis of an integrated membrane-based harvesting and effluent recycling strategy for microalgal biomass production in raceway ponds0 aTechnoeconomic analysis of an integrated membranebased harvestin cSEP a6078–60890 v53 a

Microalgae-based systems offer a sustainable route for biomass production and carbon dioxide (CO2) capture; however, their economic feasibility remains scale-dependent. This study presents a techno-economic analysis (TEA) of Monoraphidium sp. KMC4 cultivated in open raceway ponds (ORPs) using low-cost kaolin-based ceramic membranes integrated with a three-batch effluent recycling system. Four scenarios (S1–S4) were evaluated to assess the influence of production scale (1–100 ha) and electricity subsidies. Capital expenditure (CAPEX) and operating expenditure (OPEX) were quantified, and a sensitivity analysis was conducted for plant life, discount rate, biomass selling price, and utility and labor costs. Results show that small-scale systems with subsidies (S1) yield marginal profitability (net present value, NPV: $0.28 million), while unsubsidized small-scale systems (S2) remain unviable. Industrial-scale production (S4) demonstrated favorable economics with a unit biomass cost of $7.50 per kilogram, a payback period of 5.3 years, and an NPV of $145.78 million. The sensitivity analysis confirmed that the biomass selling price and utility costs are the most influential parameters that affect economic viability. Overall, the findings emphasize that economies of scale, process optimization, and resource recovery are key to widespread adoption and the feasibility of algae-based systems.

1 aAgarwalla, Ankit1 aKumar, Vinod1 aMohanty, Kaustubha uhttps://library.ncl.res.in/content/techno-economic-analysis-integrated-membrane-based-harvesting-and-effluent-recycling