01329nas a2200157   4500008004100000022001400041245009100055210006900146260010600215300001400321490000700335520065500342100002500997700002801022856012101050       2013                        eng d  a0957-416600aBase-catalyzed mukaiyama-type aldol additions, a continued quest for stereoselectivity0 aBasecatalyzed mukaiyamatype aldol additions a continued quest fo  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a1345-13630 v243 a<p>Base-catalyzed reactions of silyl enolates with carbonyl compounds are an attractive variant of conventional directed aldol reactions. Over the past two decades, the reaction has gained prominence due to its inherent advantage for stereoselective manipulations. The present review provides a brief account of developments in this area. Various approaches are grouped together in order to provide the salient features of each conceptual development. It appears that the methods which generate nascent chiral enolates or cationic siliconium species have the biggest influence on the stereoselectivity. (C) 2013 Elsevier Ltd. All rights reserved.</p>1 aSutar, Revannath, L.1 aJoshi, Navalkishore, N.  uhttps://library.ncl.res.in/content/base-catalyzed-mukaiyama-type-aldol-additions-continued-quest-stereoselectivity-001272nas a2200157   4500008004100000022001400041245009600055210006900151260010600220300001000326490000700336520059900343100002500942700002800967856011900995       2013                        eng d  a0957-416600aSystematic evaluation of a few proline derivatives as catalysts for a direct aldol reaction0 aSystematic evaluation of a few proline derivatives as catalysts   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a43-490 v243 a<p>A series of pyrrolidine derivatives were prepared and examined as catalysts for an aldol reaction. Structural variations in these molecules involved altering the sterics at the alpha-position, the position of the carbonyl group, and the acidities of the hydrogen bonding sites. The effect of these factors on catalytic activity and enantioselectivity was studied. The experimental results revealed that additional sterics at the alpha-position were detrimental. However, no correlation was found between the catalytic activity and N-H acidity. (C) 2012 Elsevier Ltd. All rights reserved.</p>1 aSutar, Revannath, L.1 aJoshi, Navalkishore, N.  uhttps://library.ncl.res.in/content/systematic-evaluation-few-proline-derivatives-catalysts-direct-aldol-reaction-001340nas a2200253   4500008004100000022001400041245013000055210006900185260007700254300001400331520038900345653001700734653001300751653002600764653001400790653002200804100002500826700001700851700002400868700002100892700002400913700002100937856012800958       2014                        eng d  a1434-193X00aGeneral approach to N-heterocyclic carbenes with a fused tetracyclic core: ligands for suzuki-miyaura cross-coupling reaction0 aGeneral approach to Nheterocyclic carbenes with a fused tetracyc  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJUL  a4482-44863 a<p>The synthesis of an N-heterocyclic carbene (NHC) based on a tetracyclic scaffold by using simple, general, and scalable chemistry is disclosed. The developed route is suitable for introducing multiple substitutions on the tetracyclic scaffold. The utility of the present NHC as a ligand in the Suzuki-Miyaura cross-coupling reaction is demonstrated with a low catalyst loading.</p>10aC-C coupling10acarbenes10aHomogeneous catalysis10aN ligands10asynthetic methods1 aSutar, Revannath, L.1 aKumar, Vinod1 aShingare, Rahul, D.1 aThorat, Shridhar1 aGonnade, Rajesh, G.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/general-approach-n-heterocyclic-carbenes-fused-tetracyclic-core-ligands-suzuki-miyaura-001247nas a2200169   4500008004100000245024800041210006900289260000800358300001400366490000900380520046500389100002400854700002500878700002500903700002100928856012800949       2017                        eng d00aRoute to benzimidazol-2-ones via decarbonylative ring contraction of quinoxalinediones: application to the synthesis of flibanserin, A drug for treating hypoactive sexual desire disorder in women and marine natural product hunanamycin analogue0 aRoute to benzimidazol2ones via decarbonylative ring contraction   cAUG  a5137-51410 v 2  3 a<p>A simple and practical method to access a variety of benzimidazol-2-ones is reported here. A series of N-alkylsubstituted benzimidazol-2-ones were synthesized by decarbonylative ring contraction starting from corresponding quinoxalinediones for the first time. The utility of the method has been demonstrated by synthesizing recently approved controversial drug flibanserin (Addyi) and a urea analogue of marine antibiotic natural product hunanamycin-A.</p>1 aShingare, Rahul, D.1 aKulkarni, Akshay, S.1 aSutar, Revannath, L.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/route-benzimidazol-2-ones-decarbonylative-ring-contraction-quinoxalinediones-application