01761nas a2200253   4500008004100000022001400041245006500055210006400120260007900184300001200263490000600275520092900281653001701210653003001227653001701257653001401274653001401288100001901302700002001321700002201341700002201363700002301385856009901408       2014                        eng d  a2191-954200aDiscontinuous two step flow synthesis of m-aminoacetophenone0 aDiscontinuous two step flow synthesis of maminoacetophenone  aGENTHINER STRASSE 13, D-10785 BERLIN, GERMANYbWALTER DE GRUYTER GMBHcAUG  a279-2850 v33 a<p>The continuous flow nitration of acetophenone followed by reduction of the meta isomer has been demonstrated using simple tubular reactors. Because of ease of separation of the desired isomer from the first step, both steps are made continuous, but separately. The continuous flow nitration was carried out in a safe manner in a shorter reaction time than the conventional approach. The choice of micromixer was seen to affect the performance of the nitration reaction. The effect of different parameters on the yield of the desired product was studied. The reduction step with sodium sulfide was found to be economical and could be carried out efficiently at 70 degrees C using sodium sulfide in ethanol, using a silicone tube. Both steps were demonstrated for several hours, yielding a sufficiently large quantity (similar to 100 g) of m-aminoacetophenone at lab scale in a single day using simple tubular reactors.</p>10aacetophenone10acontinuous flow synthesis10amicroreactor10anitration10areduction1 aTibhe, Jagdish1 aSharma, Yachita1 aJoshi, Ramesh, A.1 aJoshi, Rohini, R.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/discontinuous-two-step-flow-synthesis-m-aminoacetophenone-0