02492nas a2200253   4500008004100000022001400041245012000055210006900175260011000244300001600354490000700370520154000377100001901917700001401936700001801950700002001968700001901988700001802007700002002025700002202045700002402067700002102091856012602112       2012                        eng d  a0959-942800aPorous ZnO nanorod for targeted delivery of doxorubicin: in vitro and in vivo response for therapeutic applications0 aPorous ZnO nanorod for targeted delivery of doxorubicin in vitro  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcDEC  a24145-241540 v223 a<p>Cancer cell specific targeted delivery (TDD) by porous nanocarrier is on a high role. Here in a simple route for the synthesis of porous ZnO nanorods (ZnO) has been demonstrated. ZnO expressed very high surface area of 305.14 m(2) g(-1) (S-BET) and uniformly distributed pores of 5 nm. In continuation ZnO has been fabricated with 3-aminophosphonic acid followed by folic acid to yield folate conjugated porous ZnO nanorod (ZnO-FA). High surface area, uniformly distributed pores on its surface make the nanocarrier suitable for high drug loading (88%) of the anticancer drug doxorubicin (DOX). A pH triggered drug release was observed with minimum release in pathophysical conditions. In vitro efficacy of DOX loaded ZnO-FA (ZnO-FA-DOX) has been evaluated against breast cancer cells MDA-MB-231, which is not possible alone by DOX or ZnO-FA. Targeted scaffold with pendant -NH2 group has been covalently bonded with fluorescent dye (RITC) for cellular uptake and imaging studies in MDA-MB-231 cells; the possible pathway for cancer regression has also been evaluated. Even in vivo acute and intravenous toxicological evaluation on murine model system complemented biocompatibility of ZnO-FA in TDD. All together we have collaged a template free synthesis of porous ZnO nanorod, successful targeting on to cancer cells, high drug loading, pH triggered drug release, in vitro efficacy of ZnO-FA-DOX against MDA-MB-231 cells and in vivo compatibility as well. We envisioned the future prospect of porous ZnO nanostructures in TDD.</p>1 aMitra, Shouvik1 aSubia, B.1 aPatra, Prasun1 aChandra, Sourov1 aDebnath, Nitai1 aDas, Sumistha1 aBanerjee, Rahul1 aKundu, Subhas, C.1 aPramanik, Panchanan1 aGoswami, Arunava  uhttps://library.ncl.res.in/content/porous-zno-nanorod-targeted-delivery-doxorubicin-vitro-and-vivo-response-therapeutic-001862nas a2200265   4500008004100000022001400041245010600055210006900161260007700230300001600307490000700323520092000330653001701250653001601267653001801283653002901301653001701330100001701347700001901364700001801383700002101401700002201422700002001444856013201464       2014                        eng d  a0947-653900aMechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery0 aMechanical downsizing of a gadoliniumiiibased metalorganic frame  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAUG  a10514-105180 v203 a<p>A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (&gt;90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.</p>10aball-milling10adoxorubicin10adrug delivery10ametal-organic frameworks10ananocarriers1 aKundu, Tanay1 aMitra, Shouvik1 aPatra, Prasun1 aGoswami, Arunava1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/mechanical-downsizing-gadoliniumiii-based-metal-organic-framework-anticancer-drug-delivery-0