01854nas a2200217   4500008004100000022001400041245017300055210006900228260007700297300001400374520092900388653002101317653001601338653001901354653004001373653001901413100001901432700002701451700002901478856012901507       2008                        eng d  a1434-193X00aSuzuki cross-coupling and intramolecular aza-michael addition reaction sequence towards the synthesis of 1,10b-epi-7-deoxypancratistatins and their cytotoxicity studies0 aSuzuki crosscoupling and intramolecular azamichael addition reac  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcDEC  a5839-58473 a<p>The development of an efficient approach to the construction of a phenanthridone is described. The convergent strategy commences with the preparation of Suzuki cross-coupling reaction precursors, arylboronic acid 12 and a-iodo enone 14, from piperonylamine (9) and (-)-D-quinic acid (10), respectively. The coupling of 12 and 19 followed by a key intramolecular aza-Michael addition produced phenanthridone 21 featuring a cis-fused B-C ring junction. The syntheses of compounds 25 and 26, both of which are C-1 and C-10b epimers of the naturally occurring potent antitumor agent 7-deoxypancratistatin (2), from 21 are elaborated in detail in this paper. The cytotoxicities of 25 and 26 were evaluated against three different cancer cell lines. Compound 26 served as a moderate growth inhibitor of THP-1 monocytic cells (GI(50) = 14.5 mu g/mL). ((C) Wiley-VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)</p>10aantitumor agents10aChiral pool10aCross-coupling10aIntramolecular aza-Michael addition10aPancratistatin1 aPandey, Ganesh1 aBalakrishnan, Madhesan1 aSwaroop, Pandrangi, Siva  uhttps://library.ncl.res.in/content/suzuki-cross-coupling-and-intramolecular-aza-michael-addition-reaction-sequence-towards-001340nas a2200205   4500008004100000022001400041245012700055210006900182260011000251300001400361490000700375520048000382100002900862700002200891700002400913700002000937700002400957700002100981856013201002       2012                        eng d  a1477-052000aAntituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues0 aAntituberculosis agent diaportheone B synthesis absolute configu  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY  a5385-53940 v103 a<p>First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H(37)Rv).</p>1 aSwaroop, Pandrangi, Siva1 aRaut, Gajanan, N.1 aGonnade, Rajesh, G.1 aVerma, Priyanka1 aGokhale, Rajesh, S.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/antituberculosis-agent-diaportheone-b-synthesis-absolute-configuration-assignment-and-anti-001043nas a2200169   4500008004100000022001400041245010500055210006900160260011000229300001400339490000600353520031500359100001800674700002900692700002100721856013100742       2012                        eng d  a2046-206900aGreen synthetic route to antimalarial and antibacterial agent CJ-15,801 and its isomer cis-CJ-15,8010 aGreen synthetic route to antimalarial and antibacterial agent CJ  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a3596-35980 v23 a<p>An efficient and rapid synthesis of antiplasmodial and antibacterial agent CJ-15,801 and its isomer cis-CJ-15,801 is disclosed. We have made an attempt towards ``Ideal Synthesis'' or a step towards ``Dial-a-Molecule'' by reducing the number of steps, following atom economy, and a green synthetic route.</p>1 aKashinath, K.1 aSwaroop, Pandrangi, Siva1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/green-synthetic-route-antimalarial-and-antibacterial-agent-cj-15801-and-its-isomer-cis-cj-001419nas a2200217   4500008004100000022001400041245014100055210006900196260007100265300001400336490000700350520054400357100001800901700002900919700002400948700002400972700002900996700002401025700002101049856013101070       2013                        eng d  a0022-326300aSyntheses and determination of absolute configurations and biological activities of the enantiomers of the longtailed mealybug pheromone0 aSyntheses and determination of absolute configurations and biolo  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUN  a6281-62840 v783 a<p>Preparation and assignment of absolute configurations to both enantiomers of the sex pheromone of the longtailed mealybug, an irregular monoterpenoid with extraordinary biological activity, has been completed. Comparison of the biological activities of both enantiomers and the racemate in field trials showed that the (S)-(+)-enantiomer was highly attractive to male mealybugs, strongly suggesting that female longtailed mealybugs produce this enantiomer. The (R)-(-)-enantiomer was benign, being neither attractive nor inhibitory.</p>1 aRamesh, Remya1 aSwaroop, Pandrangi, Siva1 aGonnade, Rajesh, G.1 aThirupath, Choppari1 aWaterworth, Rebeccah, A.1 aMillar, Jocelyn, G.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/syntheses-and-determination-absolute-configurations-and-biological-activities-enantiomers-001405nas a2200241   4500008004100000022001400041245012000055210006900175260010600244300001400350490000700364520046500371653002100836653002500857653001900882653001600901653001700917100002900934700002600963700002700989700002101016856012601037       2014                        eng d  a0040-403900aEfforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment0 aEfforts towards the synthesis of microsporin B ready access to b  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4777-47790 v553 a<p>Both the isomers methyl-(2S,8R)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate and methyl-(2S,8S)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate of an unusual amino acid residue and the key fragment of microsporin B are prepared. The key steps include cross metathesis and enzymatic kinetic resolution. In addition, a linear tetrapeptide with desired components towards total synthesis is also reported. (C) 2014 Elsevier Ltd. All rights reserved.</p>10aCross metathesis10aEnzymatic resolution10aHDAC inhibitor10aMicrosporin10aTetrapeptide1 aSwaroop, Pandrangi, Siva1 aTripathy, Sibanarayan1 aJachak, Gorakhnath, R.1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/efforts-towards-synthesis-microsporin-b-ready-access-both-enantiomers-key-amino-acid-0