02031nas a2200289 4500008004100000022001400041245013300055210006900188260007300257300001200330490000900342520099500351653001501346653002601361653002601387653002101413653002201434653000901456653001501465100002201480700002201502700002501524700002101549700002401570700002701594856012001621 2007 eng d a0021-967300aEnantiomeric separation of novel anticancer agent 5-hydroxy-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-cyclopent-2-en- 1-one0 aEnantiomeric separation of novel anticancer agent 5hydroxy34meth aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJAN a184-1890 v11383 a

The enantiomers of 5-hydroxy-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-cyclopent-2-en- 1-one, a novel anticancer agent, were separated by derivatisation with caronaldehyde, separation of the resulting diastereoisomers of the corresponding esters by silica gel column chromatography and regeneration of alcohols (S)-5-hydroxy-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-cyclopent-2 -en-1-one and (R)5-hydroxy-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-cyclopent-2- en- 1-one under aqueous conditions. The absolute configuration of the enantiomers was determined by H-1 NMR studies of the corresponding Mosher esters. Alternatively, the enantiomers were separated by preparative HPLC to collect the (S)- and (R)-5-hydroxy-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-cyclopent-2 -en-1-ones with high purity which was comparable with that obtained by the chemical method. The details of these methods have been presented herein. (c) 2006 Elsevier B.V. All rights reserved.

10aAnticancer10acolumn chromatography10adiaryl cyclopentenone10adiastereoisomers10aenantioseparation10aHPLC10aResolution1 aShinde, Popat, D.1 aJadhav, Vinod, H.1 aBorate, Hanumant, B.1 aBhide, Sunil, R.1 aSonawane, Kiran, B.1 aWakharkar, Radhika, D. uhttps://library.ncl.res.in/content/enantiomeric-separation-novel-anticancer-agent-5-hydroxy-3-4-methoxyphenyl-2-34501116nas a2200217 4500008004100000022001400041245006000055210005800115260008900173300001200262490000700274520037400281653001900655653001000674653002500684100002500709700002400734700002700758700002500785856008800810 2007 eng d a0376-469900aTwo new eudesmanolides from sphaeranthus indicus (Linn)0 aTwo new eudesmanolides from sphaeranthus indicus Linn aDR K S KRISHNAN MARG, NEW DELHI 110 012, INDIAbNATL INST SCIENCE COMMUNICATIONcFEB a379-3810 v463 a

Two new eudesmanolides have been isolated from the aerial part of Sphaeranthus indicus and their structures have been established as 11 alpha,13-dihydro-3 alpha,7 alpha-dihydroxyeudesm-4-en 6 alpha, 12-olide 1, 4-en-6 beta,7 alpha-eudesmanolide 3, on the basis of spectral data and comparison of spectral data with those of reported data of compounds 2, 4 and 5.

10aeudesmanolides10aolide10aSphaeranthus indicus1 aJadhav, Ravindra, B.1 aSonawane, Kiran, B.1 aDeshpande, Nirmala, R.1 aRojatkar, Supada, R. uhttps://library.ncl.res.in/content/two-new-eudesmanolides-sphaeranthus-indicus-linn02802nas a2200241 4500008004100000022001400041245015300055210006900208260009000277300001400367490000700381520183700388653002602225653001302251653002402264100002202288700002902310700002502339700002402364700002402388700002702412856012102439 2014 eng d a1388-020900aIsolation, characterization and antihyperlipidemic activity of secoisolariciresinol diglucoside in poloxamer-407-induced experimental hyperlipidemia0 aIsolation characterization and antihyperlipidemic activity of se aTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLANDbINFORMA HEALTHCAREcSEP a1094-11030 v523 a

Context: Linum usitatissimum L. (Linaceae), commonly known as flaxseed, is a good source of dietary fiber and lignans. Earlier we reported cardioprotective, antihyperlipidemic, and in vitro antioxidant activity of flax lignan concentrate (FLC) obtained from flaxseed. Objectives: To isolate secoisolariciresinol diglucoside (SDG) from FLC and to evaluate the antihyperlipidemic activity of SDG in poloxamer-407 (P-407)-induced hyperlipidaemic mice. Material and methods: FLC was subjected to column chromatography and further subjected to preparative HPTLC to isolate SDG. The chemical structure of the isolated compound was elucidated by UV, IR, H-1 NMR, C-13 NMR, DEPT, COSY, HSQC, HMBC, ROESY, MS, and specific optical rotation was recorded. Further, we have investigated the antihyperlipidaemic effect of SDG (20 mg/kg) in P-407-induced hyperlipidaemic rats. Hyperlipidaemia was induced by intraperitoneal administration of P-407 (30% w/v). Serum lipid parameters such as total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) levels were measured. Results and discussion: The structure and stereochemistry of the isolated compound were confirmed on the basis of 1D and 2D spectral data and characterized as SDG. Finally, isolated pure SDG was screened using a P-407-induced mice model for its antihyperlipidemic action using serum lipid parameters. The isolated SDG (20 mg/kg) significantly reduced serum cholesterol, triglyceride (p<0.001), very low-density lipoprotein (p<0.05), and non-significantly increased HDL-C. Conclusion: Finally, it was concluded unequivocally that SDG showed antihyperlipidaemic effects in P-407-induced hyperlipidaemic mice. Isolated pure SDG confirms that SDG is beneficial in the prevention of experimental hyperlipidemia in laboratory animals.

10acolumn chromatography10aflaxseed10aLinum usitatissimum1 aZanwar, Anand, A.1 aHegde, Mahabaleshwar, V.1 aRojatkar, Supada, R.1 aSonawane, Kiran, B.1 aRajamohanan, P., R.1 aBodhankar, Subhash, L. uhttps://library.ncl.res.in/content/isolation-characterization-and-antihyperlipidemic-activity-secoisolariciresinol-001338nas a2200193 4500008004100000245009200041210006900133260000800202300001600210490000600226520065700232100002200889700002800911700002200939700002400961700002400985700002301009856011201032 2016 eng d00aSynthesis of (+/-)-thia-calanolide A, its resolution and in vitro biological evaluation0 aSynthesis of thiacalanolide A its resolution and in vitro biolog cNOV aS1597-S16020 v93 aA synthesis of (+/-)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel-Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoumarin 6 employing an appropriate solvent of CS2-PhNO2 in a ratio of 7:3. In its biological evaluation for anti-HIV activity, (+/-)-thia-calanolide A 3 demonstrated comparatively less activity with calanolide A and its synthetic analogue aza-calanolide. Further, (+/-)-3 has been resolved by chiral HPLC to (+) and (-)-3. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.1 aChopade, Anil, U.1 aChopade, Manojkumar, U.1 aChanda, Bhanu, M.1 aSawaikar, Dilip, D.1 aSonawane, Kiran, B.1 aGurjar, Mukund, K. uhttps://library.ncl.res.in/content/synthesis-thia-calanolide-its-resolution-and-vitro-biological-evaluation02702nas a2200313 4500008004100000022001400041245010800055210006900163260000800232300001000240490000700250520165900257653002601916653002201942653001301964653003201977653002102009100002302030700002602053700001802079700001702097700002802114700002602142700002202168700002402190700002602214700001902240856012902259 2019 eng d a0973-129600aExploring the potential of Desmodium gangeticum (L.) DC. extract against spatial memory deficit in rats0 aExploring the potential of Desmodium gangeticum L DC extract aga cAPR a78-830 v153 a

Background: A few published reports demonstrated the neuroprotective effect of Desmodium gangeticum (L.) DC. in an acute model of dementia. Objective: The purpose of the present study was to evaluate the preclinical efficacy of D. gangeticum against chronic dementia when administered prophylactically. Materials and Methods: Chronic spatial memory deficit was induced in rats by aluminum chloride (AlCl3, 10 mg/kg, i.p.). Treatment with hydroalcoholic whole plant extract of D. gangeticum (DG extract) was initiated 2 week before AlCl3 challenge and continued till the 51(st) day after the challenge, orally at the dose of 400 mg/kg/day. The spatial memory was assessed by Morris water maze test. Hippocampal and frontal cortex acetyl cholinesterase (AChE) and oxidative stress were assessed in diseased rat brains. Results: Chronic administration of AlCl3 produced spatial memory deficit in rats. Memory impairment was manifested in rats as an increase in escape latency and D-quadrant latency whereas a decrease in total time spent in D-quadrant. These behavioral alterations were reversed significantly by the treatment with DG extract. In addition, DG extract significantly increased the island time, indicating memory improvement. DG extract corrected the declined AChE in frontal cortex and altered frontal cortex/hippocampus catalase activity. Phytochemical investigation of the DG extract revealed large content of saponins among the other phytochemicals such as tannins, alkaloids, and flavonoids. Conclusion: These results indicate the possible prophylactic potential of saponin-rich DG extract against chronic memory deficit in rats.

10aAcetyl cholinesterase10aAluminum chloride10adementia10aDesmodium gangeticum (L) DC10aOxidative stress1 aChangdar, Nilanjan1 aGanjhu, Rajesh, Kumar1 aRijal, Samita1 aKumar, Ayush1 aMallik, Shanchari, Basu1 aNampoothiri, Madhavan1 aShenoy, Rekha, R.1 aSonawane, Kiran, B.1 aRao, Mallikarjuna, C.1 aMudgal, Jayesh uhttps://library.ncl.res.in/content/exploring-potential-desmodium-gangeticum-l-dc-extract-against-spatial-memory-deficit-rats