01033nas a2200157 4500008004100000245011300041210006900154260000800223300001600231490000700247520042000254100002400674700002400698700002600722856012700748 2015 eng d00aVisible light-triggered disruption of micelles of an amphiphilic block copolymer with BODIPY at the junction0 aVisible lighttriggered disruption of micelles of an amphiphilic  cOCT a17708-177110 v513 a

A visible light-cleavable polymer is synthesised to overcome the limitations of UV-sensitive polymers. Photocleavable BODIPY functionalized with an ATRP initiator and alkyne was used to obtain an amphiphilic block copolymer by conducting the click reaction and polymerization simultaneously. Micellar assembly of the polymer was disintegrated under visible light irradiation with controlled release of cargo.

1 aPatil, Naganath, G.1 aBasutkar, Nitin, B.1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/visible-light-triggered-disruption-micelles-amphiphilic-block-copolymer-bodipy-junction01982nas a2200241 4500008004100000022001400041245013900055210006900194260000900263300001200272490000700284520113000291653001101421653001901432653001301451653001801464653002901482100002401511700002901535700002101564700002601585856012901611 2024 eng d a1060-132500aVisible light and pH-responsive star copolymer and doxorubicin-polymer conjugate micelles for combination drug delivery and bioimaging0 aVisible light and pHresponsive star copolymer and doxorubicinpol cFEB  a105-1160 v613 a

Amphiphilic 3-arm star copolymer containing visible light-cleavable BODIPY group and pH-responsive imine bonds at the junction of hydrophilic poly(ethylene glycol) (PEG) and two poly(epsilon-caprolactone) (PCL) arms was synthesized by the combination of ring-opening polymerization (ROP) and click chemistry. The formation and stimuli-responsive disruption of micelles were analyzed using dynamic light scattering and transmission electron microscopy. Dual stimuli-responsive release of anticancer drugs Doxorubicin (Dox) and Camptothecin (CPT) from the micelles was studied. Micellar assemblies containing Dox conjugated to PEG-BODIPY through imine bonds were prepared and controlled release of Dox in response to visible light and pH was shown. CPT and Dox-loaded star copolymer micelles as well as CPT loaded Dox-conjugated micelles were used in cellular uptake studies on MDA-MB 231 cells, and the synergistic effect of the two stimuli on the release of the two drugs was demonstrated inside the cells. Micellar assemblies also showed excellent bioimaging properties in the cellular uptake studies. [GRAPHICS]

10aBODIPY10adrug conjugate10amicelles10apH-responsive10avisible light-responsive1 aBasutkar, Nitin, B.1 aSurapaneni, Sai, Geetika1 aAlam, Md., Shafi1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/visible-light-and-ph-responsive-star-copolymer-and-doxorubicin-polymer-conjugate-micelles02183nas a2200169 4500008004100000022001400041245012100055210006900176260000800245300001400253490000700267520154000274100002601814700001701840700002601857856013001883 2025 eng d a0743-746300aVisible light-responsive composition-dependent morphology and cargo release in mixed micelles of dendron amphiphiles0 aVisible lightresponsive compositiondependent morphology and carg cJAN a1957-19670 v413 a

2,2-Bis-(methylol)propionic acid-based second-generation polyester dendron amphiphile (T-D) containing visible light-responsive donor-acceptor Stenhouse adduct (DASA) as hydrophobic tails is synthesized. Micelles of T-D amphiphile and its mixed micelles of varying compositions with nonresponsive dendron amphiphile containing lauryl groups are prepared in aqueous solution. In transmission electron microscopy and atomic force microscopy analyses, T-D amphiphiles show rice grain-like ellipsoidal micelles as the predominant morphology. Mixed micelles display a composition-dependent morphology gradient such that the morphology changes from rice grain like to mixed to completely spherical with decreasing content of the T-D amphiphile. Complete morphology change to spherical micelles and partial reversal to ellipsoidal micelles, finally leading to ill-defined aggregates, are observed when the T-D amphiphile micelles are subjected to visible light-dark storage photoswitching cycles. Small-angle neutron scattering (SANS) analysis of 1 wt.% micellar solution in THF:water (10:90) reveals only a minor change in shape and size upon photoirradiation, and the data could be fitted to spherical or ellipsoidal model. Release of hydrophobic dye from mixed micelles is tuned by the content of the photoresponsive amphiphile. Cellular uptake and visible light-triggered release of hydrophobic drug from mixed micelles are demonstrated using MDA-MB-231 cells, suggesting their applicability for photoresponsive drug delivery.

1 aAvhad, Shankarrao, V.1 aKumar, Sugam1 aAmbade, Ashootosh, V. uhttps://library.ncl.res.in/content/visible-light-responsive-composition-dependent-morphology-and-cargo-release-mixed-micelles