01765nas a2200229   4500008004100000022001400041245012100055210006900176260007700245300001400322490000800336520087100344653002301215653003201238653001301270653002301283653003301306100002001339700002101359700002601380856012901406       2014                        eng d  a1022-135200aEffect of the branching pattern of hydrophobic dendrons on the core structure of linear-dendritic copolymer micelles0 aEffect of the branching pattern of hydrophobic dendrons on the c  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAUG  a1456-14650 v2153 a<p>Hydrophobic dendrons based on different branching patterns, viz. 3,5-di- and 3,4,5-trisubstituted phenyl rings, consist of the same backbone but exhibit different sizes, shapes, and hydrophobic densities. These dendrons are attached to poly(ethylene glycol) and the core properties of the copolymer micelles are investigated in tetrahydrofuran (THF)/water mixtures by neutron scattering. Two polymers with intermediate hydrophobicity are studied further with variations in the solvent composition and the temperature. The aggregation numbers for 3,4,5-based dendron copolymers are lower, with more THF molecules of solvation compared with the 3,5-based dendron copolymer, the difference being greater at higher generations due to different molecular shapes. The micellar core size increases in small steps with dendron size so that dye encapsulation is tuned.</p>10adiblock copolymers10alinear-dendritic copolymers10amicelles10aneutron scattering10astructure-property relations1 aKalva, Nagendra1 aAswal, Vinod, K.1 aAmbade, Ashootosh, V.  uhttps://library.ncl.res.in/content/effect-branching-pattern-hydrophobic-dendrons-core-structure-linear-dendritic-copolymer-001927nas a2200157   4500008004100000022001400041245013400055210006900189260000900258300001400267490000700281520130500288100002601593700002601619856012401645       2026                        eng d  a1525-779700aEffect of shape on cellular uptake of visible-light- and redox-responsive biodegradable linear-dendritic block copolymer micelles0 aEffect of shape on cellular uptake of visiblelight and redoxresp  cMAR   a1969-19840 v273 a<p>
	Linear-dendritic block copolymers comprising poly(epsilon-caprolactone) attached to hydrophilic 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) ester dendron via a disulfide and containing a defined number of pendent visible-light-responsive donor-acceptor Stenhouse adduct (DASA) groups are synthesized using click chemistry and postpolymerization modification. Self-assembly in aqueous solution selectively affords rice grain-like ellipsoidal, rod-like, and spherical micelles, governed by the number of DASA groups. Progressive disassembly of the micelles is observed during photoswitching cycles. Release of camptothecin depends on the DASA content under light irradiation and is enhanced by the synergistic effect of two stimuli. Cellular uptake quantified by FACS analysis is demonstrated to be influenced by the shape of the micelles, with ellipsoidal micelles exhibiting higher efficiency than spherical micelles by following clathrin- and caveolae-mediated endocytosis as major pathways for internalization. Both types of micelles were found to maintain the particle size in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum at 37 degrees C. Doxorubicin (DOX)-loaded ellipsoidal micelles under photoirradiation show significantly higher apoptosis than free DOX.</p>
1 aAvhad, Shankarrao, V.1 aAmbade, Ashootosh, V.  uhttps://library.ncl.res.in/content/effect-shape-cellular-uptake-visible-light-and-redox-responsive-biodegradable-linear