01862nas a2200265   4500008004100000022001400041245010600055210006900161260007700230300001600307490000700323520092000330653001701250653001601267653001801283653002901301653001701330100001701347700001901364700001801383700002101401700002201422700002001444856013201464       2014                        eng d  a0947-653900aMechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery0 aMechanical downsizing of a gadoliniumiiibased metalorganic frame  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAUG  a10514-105180 v203 a<p>A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (&gt;90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.</p>10aball-milling10adoxorubicin10adrug delivery10ametal-organic frameworks10ananocarriers1 aKundu, Tanay1 aMitra, Shouvik1 aPatra, Prasun1 aGoswami, Arunava1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/mechanical-downsizing-gadoliniumiii-based-metal-organic-framework-anticancer-drug-delivery-002052nas a2200205   4500008004100000022001400041245007900055210006900134260011000203300001400313490000600327520126500333100002101598700002101619700002401640700002401664700002201688700002001710856011601730       2014                        eng d  a2050-748800aMultifunctional and robust covalent organic framework-nanoparticle hybrids0 aMultifunctional and robust covalent organic frameworknanoparticl  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a7944-79520 v23 a<p>Highly dispersed Pd(0) nanoparticles were successfully immobilized into a stable, crystalline and porous covalent organic framework (COF), TpPa-1, by a solution infiltration method using NABH(4) as a reducing agent. High resolution and dark field TEM images confirmed the uniform loading of the Pd(0) nanoparticles into the TpPa-1 matrix without aggregation. This hybrid material exhibited excellent catalytic activity towards the Cu free Sonogashira, Heck and sequential one pot Heck-Sonogashira cross-coupling reactions under basic conditions, and with superior performance compared to commercially available Pd supported on activated charcoal (i.e., 1, 5 and 10 wt%). Additionally, the precursor Pd(II)-doped COF also displayed competitive catalytic activity for the intramolecular oxidative biaryl synthesis under acidic conditions. Both catalysts were found to be highly stable under the reaction conditions showing negligible metal leaching, non-sintering behavior, and good recyclability. To the best of our knowledge, the organic support used in this work, TpPa-1, constitutes the first COF matrix that can hold both Pd(0) nanoparticles and Pd(II) complex without aggregation for catalytic purposes under both highly acidic and basic conditions.</p>1 aPachfule, Pradip1 aPanda, Manas, K.1 aKandambeth, Sharath1 aShivaprasad, S., M.1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/multifunctional-and-robust-covalent-organic-framework-nanoparticle-hybrids-0