01420nas a2200181   4500008004100000022001400041245013000055210006900185260011000254300001200364490000600376520064300382100001801025700002201043700002001065700002201085856013101107       2011                        eng d  a1759-995400aSynthesis of glycopolypeptides by the ring opening polymerization of O-glycosylated-alpha-amino acid N-carboxyanhydride (NCA)0 aSynthesis of glycopolypeptides by the ring opening polymerizatio  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a805-8110 v23 a<p>The novel synthesis of O-glycosylated lysine-NCA from a stable glycosyl donor and a commercially available protected amino acid in very high yield is reported. These O-glycosylated lysine-NCA monomers underwent ring opening polymerization using simple primary amine initiators to form well defined, high molecular weight homoglycopolypeptides and diblock co-glycopolypeptides. The synthesis of azide labelled end functionalized glycopolypeptides and amphiphilic diblock copolypeptides is also reported. This methodology represents an easy and practical route to the synthesis of O-glycosylated polypeptides with 100% glycosylation.</p>1 aPati, Debasis1 aShaikh, Ashif, Y.1 aHotha, Srinivas1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-glycopolypeptides-ring-opening-polymerization-o-glycosylated-alpha-amino-acid-n-000496nas a2200133   4500008004100000022001400041245005300055210005200108260006700160490000800227100001800235700002200253856008700275       2012                        eng d  a0065-772700aSynthesis and self-assembly of glycopolypeptides0 aSynthesis and selfassembly of glycopolypeptides  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAmer Chem SoccMAR0 v2431 aPati, Debasis1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-and-self-assembly-glycopolypeptides-002364nas a2200193   4500008004100000022001400041245009200055210006900147260007100216300001400287490000700301520165100308100001601959700001801975700001701993700001702010700002202027856012102049       2012                        eng d  a1525-779700aSynthesis of silk fibroin-glycopolypeptide conjugates and their recognition with lectin0 aSynthesis of silk fibroinglycopolypeptide conjugates and their r  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a3695-37020 v133 a<p>Silk fibroin (SF), the natural fibrous protein created by the Bombyx mori silk worm, is being increasingly excellent mechanical strength, high oxygen/water permeability, excellent mechanical strength; high oxygen/water:permeability, and biocompatibility: :It is also well known that surface. modification of SF, With Organic ligands such as the extracellular protein :binding. Arg-Gly-Asp, (RGD) peptides:,: help adhesion and,proliferation. of cells better-a key; requirement for it to function as extracellular. matrices; In this, Work, We have conjugated synthetic glycopolypeptides (GPs) that were synthesized by controlled ring opening polymerization of alpha-manno-lys N-carboxyanhydrides (NCAs) onto SF by using Cu catalyzed click reaction to synthesize 1 a new hybrid :Material (SF GP), Which We believe will have :both the mechanical properties of native SF and the molecular recognition property of the carbohydrates in the GP. By controlling the :amount of GP grafted onto SF, we have made three SF GP conjugates that differ in their ability to assemble into films. SF GP conjugates having a very high content of GP formed completely water soluble brush like polymer that displayed very high affinity toward the lectin concanavalin-A (Con-A) Films cast from SF-GP conjugates using lower amounts of grafted GP were more stable in water, and the stability can be modulated by varying the amount of G grafted. The water insoluble film SF-GP(25) was also found to bind to fluorescently labeled Con A, as was seen by confocal microscopy Such SF-GP hybrid films may be useful as mimics of extracellular matrices for tissue engineering:</p>1 aDas, Soumen1 aPati, Debasis1 aTiwari, Neha1 aNisal, Anuya1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-silk-fibroin-glycopolypeptide-conjugates-and-their-recognition-lectin-0