01148nas a2200157   4500008004100000022001400041245011800055210006900173260007100242300001200313490000600325520049300331100002000824700001700844856012900861       2005                        eng d  a1520-476600aDiversity oriented synthesis of tricyclic compounds from glycals using the ferrier and the pauson-khand reactions0 aDiversity oriented synthesis of tricyclic compounds from glycals  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a968-9760 v73 a<p>Diversity oriented synthesis of tricyclic compounds was achieved using a combination of the Ferrier reaction and the Pauson-Khand reaction. Ferrier reaction was effected using NbCl5, and the Pauson-Khand reaction was carried out using CO2(CO)(8), acetonitrile-dimethoxyethane. Michael additions using various alkyl, aryl, and heterocyclic thiols were also performed successfully. The Ferrier, Pauson-Khand, and Michael addition reactions were found to be highly diastereoselective.</p>1 aHotha, Srinivas1 aTripathi, A.  uhttps://library.ncl.res.in/content/diversity-oriented-synthesis-tricyclic-compounds-glycals-using-ferrier-and-pauson-khand-002309nas a2200217   4500008004100000022001400041245011600055210006900171260007100240300001400311490000700325520147400332100002501806700002201831700002001853700001901873700003001892700002001922700001801942856013101960       2009                        eng d  a0743-746300aDendritic effect of ligand-coated nanoparticles: enhanced apoptotic activity of silica-berberine nanoconjugates0 aDendritic effect of ligandcoated nanoparticles enhanced apoptoti  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB  a2339-23470 v253 a<p>We describe the synthesis and biological characterization of a novel prototype, namely, silica nanoconjugates bearing a covalently linked berberine, a plant alkaloid known to have antiproliferative activity. The effect of synthesized nanoconjugates on cell proliferation, the cell cycle profile, and apoptosis in the human cervical carcinoma cell line (HeLa), human hepatocellular liver carcinoma cell line (HepG2), and human embryonic kidney (HEK) 293T cell line has been studied and compared with the results obtained for free berberine. Our results show that all the nanoconjugates display higher antiproliferative activity than free berberine. The ability of these nanoconjugates to inhibit cellular proliferation is mediated by the cell cycle arrest at the G1 phase. Moreover, silica nanoconugates caused selective apoptotic arrest with a higher efficiency than free berberine followed by apoptotic cell death as shown by quantitative fluorescence-activated cell sorting analyses. Efficiency of the nanoconjugates increases upon an increase in the linker chain length, demonstrating the distinct role of the spacer chain that conjugates nanoparticles and ligands. The actual reason to show enhanced efficiency by the nanoconjugates has not been elucidated in the present study; however, we hypothesize that an increase in local concentration due to the confinement of a ligand on the nanosurface (''dendritic'' effect) might have led to the observed effect.</p>1 aHalimani, Mahantappa1 aChandran, Prathap1 aKashyap, Sudhir1 aJadhav, V., M.1 aPrasad, Bhagavatula L. V.1 aHotha, Srinivas1 aMaiti, Souvik  uhttps://library.ncl.res.in/content/dendritic-effect-ligand-coated-nanoparticles-enhanced-apoptotic-activity-silica-berberine-0