01688nas a2200265   4500008004100000022001400041245009100055210006900146260007100215300001600286490000600302520077300308653001901081653001401100653002601114653001701140653001701157100002101174700002301195700002101218700002401239700002701263700001701290856011501307       2014                        eng d  a1944-824400aEnhancing cubosome functionality by coating with a single layer of poly-epsilon-lysine0 aEnhancing cubosome functionality by coating with a single layer   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT  a17126-171330 v63 a<p>We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-epsilon-lysine. Poly-epsilon-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-epsilon-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.</p>10abioconjugation10acubosomes10adrug delivery vehicle10adual loading10atheranostics1 aDeshpande, Sonal1 aVenugopal, Edakkal1 aRamagiri, Shobha1 aBellare, Jayesh, R.1 aKumaraswamy, Guruswamy1 aSingh, Neetu  uhttps://library.ncl.res.in/content/enhancing-cubosome-functionality-coating-single-layer-poly-epsilon-lysine-001364nas a2200193   4500008004100000022001400041245012200055210006900177260007100246300001400317490000600331520059200337100001800929700002100947700002400968700003000992700001701022856013101039       2014                        eng d  a2161-165300aMitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery0 aMitigating the cytotoxicity of graphene quantum dots and enhanci  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT  a1064-10680 v33 a<p>Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before their full potential could be completely realized in biomedicine. A simple method for mitigating the toxicity of GQDs by embedding them in PEG matrix is reported here. The enhanced biocompatibility of polymer modified, P-GQDs, is attributed to reduced reactive oxygen species generation, as measured by an intracellular ROS assay. We also demonstrate the enhanced loading and efficient intracellular delivery of therapeutics by P-GQDs.</p>1 aChandra, Anil1 aDeshpande, Sonal1 aShinde, Dhanraj, B.1 aPillai, Vijayamohanan, K.1 aSingh, Neetu  uhttps://library.ncl.res.in/content/mitigating-cytotoxicity-graphene-quantum-dots-and-enhancing-their-applications-bioimaging-0