01622nas a2200229   4500008004100000022001400041245009700055210006900152260009900221300000900320490000800329520077500337653001101112653001301123653001301136653002101149653002401170100002301194700002501217700002701242856012301269       2014                        eng d  a0008-621500aMyo-Inositol 1,3-acetals as early intermediates during the synthesis of cyclitol derivatives0 aMyoInositol 13acetals as early intermediates during the synthesi  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcNOV  a8-140 v3993 a<p>Synthetic sequences starting from commercially available myo-inositol necessarily involve protection-deprotection strategies of its six hydroxyl groups. Several strategies have been developed/attempted over the last several decades leading to the synthesis of naturally occurring phosphoinositols, their analogs, and cyclitol derivatives. Of late, myo-inositol 1,3-acetals, which can be obtained by the reductive cleavage of myo-inositol orthoesters have emerged as early intermediates for the synthesis of phosphorylated and other inositol derivatives. This mini-review is an attempt to illustrate the economy and convenience of using myo-inositol 1,3-acetals as early intermediates during syntheses from myo-inositol. (C) 2014 Elsevier Ltd. All rights reserved.</p>10aAcetal10aCyclitol10aInositol10aProtecting group10aSignal transduction1 aGurale, Bharat, P.1 aSardessai, Richa, S.1 aShashidhar, Mysore, S.  uhttps://library.ncl.res.in/content/myo-inositol-13-acetals-early-intermediates-during-synthesis-cyclitol-derivatives-001305nas a2200169   4500008004100000245007900041210006900120260000800189300001000197490000800207520071400215100002300929700002700952700002500979700002401004856010701028       2018                        eng d00aInositol to aromatics -benzene free synthesis of poly oxygenated aromatics0 aInositol to aromatics benzene free synthesis of poly oxygenated   cMAY  a38-440 v4613 aA method for the preparation of benzene derivatives from myo-inositol, an abundantly available phyto chemical is described. 1,3-Bridged acetals of inososes undergo step-wise elimination leading to the formation of polyoxygenated benzene derivatives. This aromatization reaction proceeds through the intermediacy of a beta-alkoxyenone, which could be isolated. This sequence of reactions starting from myoinositol, provides a novel route for the preparation of polyoxygenated benzene derivatives including polyoxygenated biphenyl. This scheme of synthesis demonstrates the potential of myo-inositol as a sustainable non-petrochemical resource for aromatic compounds. (C) 2018 Elsevier Ltd. All rights reserved.1 aGurale, Bharat, P.1 aShashidhar, Mysore, S.1 aSardessai, Richa, S.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/inositol-aromatics-benzene-free-synthesis-poly-oxygenated-aromatics01468nas a2200181   4500008004100000245015200041210006900193260000800262300001000270490000800280520075300288100001801041700002501059700002701084700002301111700002401134856012801158       2018                        eng d00a Lithium hydride as an efficient reagent for the preparation of 1,2-anhydro inositols: does the reaction proceed through 'axial rich' conformation?0 aLithium hydride as an efficient reagent for the preparation of 1  cJUL  a32-360 v4633 ascyllo-Inositol derived 1,2-trans-diequatorial halohydrins can be efficiently converted to the corresponding epoxides in the presence of lithium hydride. The structure of one of the epoxides was determined by single crystal X-ray diffraction analysis. This provides a potential route for the preparation of ring modified inositol derivatives. DFT calculations suggest that this epoxide formation could be proceeding through the intermediacy of the cyclohexane ring-inverted axial-rich conformer (1,2-trans-diaxial halohydrin). This is supported by the results of DFT calculations on the formation of inositol orthoformate, where the product is locked in the axial-rich conformation, while the starting inositol has the equatorial-rich conformation.1 aSarkar, Nitai1 aSardessai, Richa, S.1 aShashidhar, Mysore, S.1 aTamboli, Majid, I.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/lithium-hydride-efficient-reagent-preparation-12-anhydro-inositols-does-reaction-proceed