01724nas a2200157   4500008004100000245009600041210006900137260000800206300001600214490000600230520114000236100001801376700002501394700002901419856011801448       2019                        eng d00aPolyesteramide of neem oil and its blends as an active nanomaterial for tissue regeneration0 aPolyesteramide of neem oil and its blends as an active nanomater  cJUL  a3341–33510 v23 a<p>Neem oil gained importance due to its antibacterial properties. Therefore, it is extensively being used for various applications. Oils can be polymerized as a polyesteramide to extend their utility as biomaterials. In our studies, we synthesized polyesteramide from neem oil and various compositions of blends were prepared with the drug, chlorohexidine digluconate (CH) to develop a nanomaterial for tissue regeneration. The studies such as cytotoxicity, biodegradable, antibacterial, <i>in vitro</i> drug release, <i>in vivo</i> wound healing, and histopathological studies were performed to identify their potential for tissue regeneration. <i>In vivo</i> wound healing studies of the nanofiber mats with and without CH recorded a faster healing rate as compared to the commercial cream (povidone–iodine). Most importantly, there was no requirement of repeated application of nanofiber mats during the treatment. The histopathology studies also suggested the re-epithelialization of the wounds. Hence, these nanomaterials are considered to be environmentally safe scaffolds for efficient tissue regeneration applications.</p>
1 aKilli, Naresh1 aPawar, Anil, Tukaram1 aGundloori, Rathna, V. N.  uhttps://library.ncl.res.in/content/polyesteramide-neem-oil-and-its-blends-active-nanomaterial-tissue-regeneration02692nas a2200169   4500008004100000245007400041210006900115260000900184300001600193490000700209520210900216100002102325700001802346700002902364700002902393856010002422       2021                        eng d00aPEGylated ethyl cellulose micelles as a nanocarrier for drug delivery0 aPEGylated ethyl cellulose micelles as a nanocarrier for drug del  cNOV   a30532-305430 v113 aNatural polymers provide a better alternative to synthetic polymers in the domain of drug delivery systems (DDSs) because of their renewability, biocompatibility, and low immunogenicity; therefore, they are being studied for the development of bulk/nanoformulations. Likewise, current methods for engineering natural polymers into micelles are in their infancy, and in-depth studies are required using natural polymers as controlled DDSs. Accordingly, in our present study, a new micellar DDS was synthesized using ethyl cellulose (EC) grafted with polyethylene glycol (PEG); it was characterized, its properties, cell toxicity, and hemocompatibility were evaluated, and its drug release kinetics were demonstrated using doxorubicin (DOX) as a model drug. Briefly, EC was grafted with PEG to form the amphiphilic copolymers EC-PEG1 and EC-PEG2 with varying PEG concentrations, and nano-micelles were prepared with and without the drug (DOX) via a dialysis method; the critical micelle concentrations (CMCs) were recorded to be 0.03 mg mL(-1) and 0.00193 mg mL(-1) for EC-PEG1 and EC-PEG2, respectively. The physicochemical properties of the respective nano-micelles were evaluated via various characterization techniques. The morphologies of the nano-micelles were analyzed via transmission electron microscopy (TEM), and the average size of the nano-micelles was recorded to be similar to 80 nm. In vitro, drug release studies were done for 48 h, where 100% DOX release was recorded at pH 5.5 and 52% DOX release was recorded at pH 7.4 from the micelles. In addition, cytotoxicity studies suggested that DOX-loaded micelles were potent in killing MDA-MB-231 and MCF-7 cancer cells, and the blank micelles were non-toxic toward cancerous and normal cells. A cellular uptake study via fluorescence microscopy indicated the internalization of DOX-loaded micelles by cancer cells, delivering the DOX into the cellular compartments. Based on these studies, we concluded that the developed material should be studied further via in vivo studies to understand its potential as a controlled DDS to treat cancer.1 aSingam, Amarnath1 aKilli, Naresh1 aPatel, Pratikshkumar, R.1 aGundloori, Rathna, V. N.  uhttps://library.ncl.res.in/content/pegylated-ethyl-cellulose-micelles-nanocarrier-drug-delivery