01179nas a2200217   4500008004100000022001400041245008600055210006900141260010600210300001400316490000700330520034900337653002300686653001800709653002800727653001200755653002400767100002400791700002600815856012000841       2013                        eng d  a0040-403900aOne-pot migration-formylation of benzyl aryl ethers under duff reaction condition0 aOnepot migrationformylation of benzyl aryl ethers under duff rea  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a4789-47920 v543 a<p>A one-pot migration-formylation of benzyl aryl ethers under Duff reaction condition is described. The reaction was performed with HMTA (hexamethylene tetramine) and TFA (trifluoroacetic acid). Under the optimal reaction conditions, a variety of Bn and PMB ethers underwent ortho rearrangement. (C) 2013 Elsevier Ltd. All rights reserved.</p>10aBenzyl aryl ethers10aDuff reaction10aHexamethylene tetramine10aOne-pot10aortho Rearrangement1 aChavan, Subhash, P.1 aLasonkar, Pradeep, B.  uhttps://library.ncl.res.in/content/one-pot-migration-formylation-benzyl-aryl-ethers-under-duff-reaction-condition-000993nas a2200217   4500008004100000022001400041245008000055210006900135260007500204300001400279490000700293520023200300653002500532653001300557653001600570653002000586653000900606100002400615700002600639856011000665       2013                        eng d  a0039-788100aSimple synthesis of the novel antihistaminic drug olopatadine hydrochloride0 aSimple synthesis of the novel antihistaminic drug olopatadine hy  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcDEC  a3399-34030 v453 a<p>A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic ether to introduce 3-(dimethylamino)propylidene group as the side chain.</p>10aantihistaminic drugs10achelates10aLewis acids10aspiro compounds10azinc1 aChavan, Subhash, P.1 aLasonkar, Pradeep, B.  uhttps://library.ncl.res.in/content/simple-synthesis-novel-antihistaminic-drug-olopatadine-hydrochloride-001373nas a2200253   4500008004100000022001400041245011200055210006900167260007500236300001400311490000700325520044500332653001900777653001100796653002300807653001500830653002500845100002400870700002400894700002600918700002400944700002500968856012600993       2014                        eng d  a0936-521400aFacile and convenient synthesis of (+/-)-Biotin via MgCl2/Et3N-mediated C-C coupling and mitsunobu reaction0 aFacile and convenient synthesis of Biotin via MgCl2Et3Nmediated   aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcDEC  a2879-28820 v253 a<p>A synthesis of (+/-)-biotin is described starting from simple starting materials viz. cyclohexanone and amino malonic acid ester. The key steps involved are MgCl2/Et3N coupling of amino malonic acid ester derivative and acid chloride, Mitsunobu reaction, ozonolysis, Staudinger reduction, novel urea formation, and subsequent dibenzylation. This approach is economical and involves high-yielding steps and simple reaction conditions.</p>10aAppel reaction10abiotin10aMitsunobu reaction10aOzonolysis10aStaudinger reduction1 aChavan, Subhash, P.1 aChavan, Prakash, N.1 aLasonkar, Pradeep, B.1 aKhairnar, Lalit, B.1 aKadam, Appasaheb, L.  uhttps://library.ncl.res.in/content/facile-and-convenient-synthesis-biotin-mgcl2et3n-mediated-c-c-coupling-and-mitsunobu-001580nas a2200181   4500008004100000022001400041245019800055210006900253260000900322300001400331490000700345520082500352100002401177700002501201700002601226700002401252856012201276       2018                        eng d  a1523-706000aSynthesis of 3-azidopiperidine skeleton employing ceric ammonium nitrate (CAN)-mediated regioselective azidoalkoxylation of enol ether: total synthesis of d-2 receptor agonist (+/-)-quinagolide0 aSynthesis of 3azidopiperidine skeleton employing ceric ammonium   cNOV   a7011-70140 v203 aThe total synthesis of (+/-)-quinagolide, which is a D-2 receptor agonist, was accomplished via a ceric ammonium nitrate (CAN)-mediated regioselective azidoalkoxylation of enol ether route. Key features of the synthesis include Claisen rearrangement, PPTS (pyridinium p-toluene-sulfonate)-catalyzed one-pot acetal deprotection, followed by a diastereoselective Henry reaction, which enables construction of the required trans ring junction and CAN-mediated regioselective azidoalkoxylation of enol ether. The PPTS-catalyzed intramolecular diastereoselective Henry reaction to fix three contiguous stereocenters on tetrahydronaphthalene and the first-of-its-kind synthesis of the 3-azidopiperidine skeleton, using a CAN -mediated regioselective azidoalkoxylation of enol ether, are important findings of the present work.1 aChavan, Subhash, P.1 aKadam, Appasaheb, L.1 aLasonkar, Pradeep, B.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/synthesis-3-azidopiperidine-skeleton-employing-ceric-ammonium-nitrate-can-mediated