01699nas a2200241   4500008004100000022001400041245003900055210003800094260008300132300001200215490000600227520095700233653001901190653001901209653002501228653002301253653001501276653002401291100002101315700002201336700002301358856007601381       2014                        eng d  a2062-249X00aContinuous-flow meerwein arylation0 aContinuousflow meerwein arylation  aPRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARYbAKADEMIAI KIADO RTcDEC  a211-2160 v43 a<p>The continuous-flow Meerwein arylation is demonstrated for a set of few aryl donors (anilines and m-aminoacetophenone) and specific radical acceptors. Homogeneous catalyst (CuBr in HBr and CuCl in HCl) was used to facilitate the reaction. The effect of parameters, viz., temperature, catalyst concentration, residence time, and concentration of the radical acceptor on the yield of the arylated product, was studied. The yield of the aryl derivative obtained by continuous-flow syntheses was always better than the respective experiments in batch mode. Flow synthesis allows easy variation in these parameters and thus allows going close to the maximum possible yields in a system where the relative rates of different reactions create a complex situation. Temperature plays a crucial role by affecting the rates as well as by governing the system homogeneity. The nitrogen bubbles generated in the reaction helped to avoid any channel blockage.</p>10adiazonium salt10aflow chemistry10ahomogeneous catalyst10aMeerwein arylation10amicromixer10amultistep synthesis1 aBhaya, Vinay, G.1 aJoshi, Ramesh, A.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/continuous-flow-meerwein-arylation-0