01359nas a2200181   4500008004100000022001400041245010800055210006900163260000800232300001400240490000700254520071200261100001800973700001700991700001701008700002001025856013201045       2026                        eng d  a1523-706000aDearomative domino approach for stereoselective construction of functionalized bridged [4.3.1] bicycles0 aDearomative domino approach for stereoselective construction of   cJUN  a8142-81470 v283 a<p>
	We report a dearomative (5+2) cycloaddition/oxa-Michael addition cascade strategy that enables concise construction of functionalized bridged [4.3.1] bicyclic frameworks. This base-mediated, one-pot process reveals an unconventional reactivity mode of alpha-arylidene pyrazolones, wherein they function as C2 synthons in dearomative addition to oxidopyrylium intermediates derived from readily accessible acylated pyranones, affording oxygen-bridged [4.3.1] bicycles bearing four stereocenters with excellent diastereocontrol. DFT studies firmly establish the operative reaction pathway and indicate (3+3) spiroannulation as a crucial competing process consistent with the experimental findings.</p>
1 aKaur, Ravneet1 aPandya, Rinu1 aVanka, Kumar1 aSingh, Ravi, P.  uhttps://library.ncl.res.in/content/dearomative-domino-approach-stereoselective-construction-functionalized-bridged-431-bicycles